5J6O


Conserved Protein Domain Family
PS-DH

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pfam14765: PS-DH (This model is not part of the current CDD release)
Polyketide synthase dehydratase N-terminal domain
This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products.
Statistics
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PSSM-Id: 521427
Aligned: 62 rows
Threshold Bit Score: 65.8873
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J6O_A        140 HMLDLPVLQEQCSEQViSSE--E-FYEFFSAIQIDY-----GSGHKGI---DKVYv-GPGQVLAKLILPLSVTGSVd--- 204  Brevibacillus...
Q609J6       2104 AEAGETALPPRQLLGI-VPK--VdLYGSVLFQ---------GPLFQRI---SGVEslDDNHVV--FVTEARAETVRapeg 2166 Methylococcus...
WP_013334444  918 QKGAKIQPLTGELLAI-EPK--TdLYGSLLFQ---------GQLFQRL---EGVFtlSREESL--LKSQVFPSRDLkesg 980  Gloeothece ve...
WP_011904512 1599 GGQSRPCARMGVAGPE-ANTihS-WYGSVLFHEGQM---------RRLlcaEPV---------SAFAVRAVVEAGDperw 1658 Salinispora t...
WP_015794934 1608 GDARPVDRDTAPRIPL-DPA--AeLYGPVLFQ---------GDRFQRLlgyHELEarGCVAAI---------SNQArddw 1666 Catenulispora...
WP_012825950 1612 ATSGTDGEAEEAGVPL-QPL--AeLYDAVLFH---------GERFRRVrryRELRakS-----CTVEVDVVEARTLaatw 1674 Haliangium oc...
Q1IUI0       2594 LHKHPPELSSGVRPHL-SPD-------SIVDSAKIYrvyfhGPAYQVL---ERAWw-DGTHLIGEMSINLPFNHQPes-- 2659 Candidatus Ko...
Q7NDK9       2867 ASVGVPAPLAVAGSAL-DIA--T-AYREHTFH---------GPHFQLL---TALDrlGEQGIDARVRPSEPARFFEtaet 2930 Gloeobacter v...
Q7NJ74        646 LPSSTQSHRSDCAREG-SFA----VAPLYEDGTLFH-----GPSFRGL---EAVLslDARRVEVRCRVLPPDAACQgqf- 711  Gloeobacter v...
WP_011874360 1403 PAVSVPELLADGREMD-LES----FYERTSRHLLF------GPTFRHV---RSVRstGDSSVVGEIVVPHNRGLFSfgt- 1467 Saccharopolys...
5J6O_A        205 --------qFVLHPSLMDSALQA-SVELTLSsrhvmssdslaKRKPVMPFALEEMEIIR---PCTSEMWAYVRYsdgs-- 270  Brevibacillus...
Q609J6       2167 fsdtvraplVLGDPFYRDTLLQAgQLTLTPD--------------VCLPVHIGRIDLYR-------QINDGGVYraraei 2225 Methylococcus...
WP_013334444  981 fpqgqgtdlLLGDPYFRDVLLQSmQLNIPQD--------------ICLPVEIAEIHLLE------NPSLAQGERiitail 1040 Gloeothece ve...
WP_011904512 1659 fasflgqdlLLGSPGGHDAAIHSlLACAPHR--------------RVLPVGAAEVVVWQ---------PLRGRLtveare 1715 Salinispora t...
WP_015794934 1667 fgsfhpadlILADPGTRDALMHSiQCCVPDA--------------TLLPASVERLWLAD-----PKRARPLPEVtlhaae 1727 Catenulispora...
WP_012825950 1675 fgpyilaeiVLGDPGARDAAIHAiQACIPQR--------------RLLPVGIEQLRIEP----ERTMPNVAGPLrihane 1736 Haliangium oc...
Q1IUI0       2660 -------lpTQIAPRLIELCFQTaGLWEMGA-----------NSKLGLPTRVDQVVAWPmanAVPHPLYAVVTPh----- 2716 Candidatus Ko...
Q7NDK9       2931 ------lpaWFFDPGLLDTIPQLaLFWARTH-----------QGSFALPSRIGRVVRFD-------SEPLVGPMriafrl 2986 Gloeobacter v...
Q7NJ74        712 -------paRAFNPYILDQLLQAaLVFVQHH-----------HRQGCLPARVECIEQFR-------SPAFGEVFtidfec 766  Gloeobacter v...
WP_011874360 1468 ------sprFSAMPTVIDNAWRApLMWIYEE-----------TGRFCVPVSIGTMRFHRs-pLPTERVYAFSRVtrme-- 1527 Saccharopolys...
5J6O_A        271 -qagNKVEKYDIDLCDDIGTICVRMKGFTSRVLEREIQTD 309  Brevibacillus brevis NBRC 100599
Q609J6       2226 tqrnGHRVLADVVVYDDNDRIVERIENYEVHMLEHGADLP 2265 Methylococcus capsulatus
WP_013334444 1041 nekqGREYICEVIATTRDGVIVEHLKGYRLRILEEHPENP 1080 Gloeothece verrucosa
WP_011904512 1716 vwhsADEYVFDVEVTHSGG-PVARWRGLRLRAVGENPEFM 1754 Salinispora tropica
WP_015794934 1728 rsrtGDTYIYDIEVRDLDGVLVERWDGLTLQAVRKQDGTG 1767 Catenulispora acidiphila
WP_012825950 1737 rihdGDRFVYDLEVRDGHGQIVERWVGLTLQAVGPIAPGR 1776 Haliangium ochraceum
Q1IUI0       2717 ----PEHGTFDAEVVDADGNRYLRVDGYHTTALPAPIDPE 2752 Candidatus Koribacter versatilis Ellin345
Q7NDK9       2987 tsvhDHQIVYDATVIDSQGRVRLLLEDGESNCSRALNRLA 3026 Gloeobacter violaceus
Q7NJ74        767 tahsEAGVVGEAAAYDAGGRLCVRMQGMHLTMGPQLKSLF 806  Gloeobacter violaceus
WP_011874360 1528 -tsaEVPIHVDTQIIDDAGRLLCDITDLVLTKVAEDAVEP 1566 Saccharopolyspora
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