Conserved Protein Domain Family
HPS3_Mid

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pfam14762: HPS3_Mid (this model, PSSM-Id:464301 is obsolete)
Hermansky-Pudlak syndrome 3, middle region
This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Statistics
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PSSM-Id: 464301
Aligned: 16 rows
Threshold Bit Score: 368.642
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019202713  275 RHQELLGD-RAKDCDIPVSIEK-----TGL--EEG-GQYALSYVLFRRFSPEFFQGCSVDEMQ--LHSLQLYPLFT---- 339 
EEN52758      308 NPTEVLGP-VDCVQGRPITVEWaglysVGIsiKGMnAQLSTTTLLYRRFAPGDTAYTTVDGA---LHSLQFLPTYSkdga 383 
EFN72601      377 GPGHALSPfILNSADIRIFIKT-----TSPdiGWS-ENYIIKNLLCLKINAGNNN-IKIDGILdiFRCLILKPLYMkrec 449 
XP_006007914  256 QPVELLGT-DASTSGLLITLES-----TGLenEQS-SCLQVCHILYRQFAPDYSQISSAEETS--LHSLQLVPMYYtgnl 326 
XP_012818776  254 RPMELISE-ECKMCGIGVSPED---------------CTQVCHLLYRRFAPDFTEGIHVENTR--LHSLQLLPMYKtgis 315 
XP_015147341  261 KPVELLGE-ESKLCKIPVTLES-----TELstEDK-KHFEVQYLLFRRFTPDQSPFGFCEETK--LHSVQFLPVYQtgss 331 
XP_003766113  265 KPTELLGE-VSRQSGLSITLES-----VGLkeEKA-GPSRVHSILYRRFTPDVS-YVLPEDTR--LHSLQLLPIYQtgav 334 
ELK00543      234 KPMELLGE-KSEQSGISITLES-----TGLddEKI-NYFHVQHLLYRRFAPDISSYVLSDDIK--LHSLQLLPIYQtgsl 304 
4_pfamImport    1 KPMELLGK-KSEQSGLSITLES-----TGLadEKL-QYVHVQHLLYRRFAPDISAYVLPDDIK--LHSLQLLPIYQtgtf 71  
XP_015216138  258 RNQELLGE-EARECGVSVTLES-----TSLeqESR-AELGVTYVLYrRFAPDFSEGCSVEDTR--LHSLQLLPIFAg--- 325  spotted gar
XP_019202713  340 ---GNQ--------------SVSP----DE-PSCVFCFFSLPTMGYLYSLKGGVE------LLSA-YQYPEKVLEAALTD 390 
EEN52758      384 dksEKSrrhrvsvlpaegrcSPLHpnpqEGtLHGLCCFFTGPRQGFLYDIFDGAN------LLAS-YPYTADTSKVVAGD 456 
EFN72601      450 nvtGVK--------------KSMLksdkYRyLQGVSCFVCTTQEGYLYHFSAASNnsldatCLTT-YPFTAPVHHVALEH 514 
XP_006007914  327 vsdGQP--------------KRNE----RK-LLSLFCFFSLPHFGYLYNIKSTIE------LIST-YQYPDKSQQVVLSP 380 
XP_012818776  316 fatDPK--------------SATPq---KE-VLVMFCFFSMPHTGFLYSIGSTVK------LLSL-YQYPETSQQAVLTP 370 
XP_015147341  332 vtaNEE--------------TENK----RE-LLSLFCFFSLPHVGYLYSVGKLVE------LIST-YQYSEKSEQAVLTP 385 
XP_003766113  335 sadGKS--------------SPQE----KE-LLSLFCFFSLPHIGYLYMAVKSVE------LMSV-YQYPEKSQQAVLTP 388 
ELK00543      305 tsdRKN--------------SSQE----KE-LLSLFCFFSLPHVGYLYMVVKSVE------LMSI-YQYPERSQQAVLTP 358 
4_pfamImport   72 dskLEE--------------KVPR----KE-PRNL--AFQIPRIIWLSILTVVNR------LGSCrWRFLSGGAAVLITT 124 
XP_015216138  326 --pSDQ--------------DVADevkhRE-PTSVFCFFSLPNTGYLYSIESSVE------LVST-YLYPEKAQQAALTG 381  spotted gar
XP_019202713  391 HLLHVITKSALQCFTVRCAALAARIEDPYIDTTMKACPPCSLEVCALRMQLFIGLRSMCVYGRHV----ILLSAADAETS 466 
EEN52758      457 SLLHAVTRNGLETYTLRKFAAAVHRMED-IDNIHNTCPHPNMDICLIGMRPFIAIQDISVCTSHV----LLLSKVE---- 527 
EFN72601      515 TILHALTEAGLESYTLR-LSHHIAKLSNCMDGIRVTCPSITEPVSLIGLRPFLGIQKLLHTKTYI----VLLAKAD---- 585 
XP_006007914  381 QFLHVITRNSLQCFTVRCSAVAARDEDPYVDTTLKACPPVTMGVCALRIQLFIGLQALCHFKNHI----ILLTKADG--- 453 
XP_012818776  371 QFLHVITRNNLQCFTVRCSAAAVREEDPYIDTTMKSCPPVSMDVCTLRMQLFIGLKAIAHFKNYL----IILTKTNMEAT 446 
XP_015147341  386 QFLHVITSESLQCFTVRCSAAAARDEDPYIDTTVKACPPVTLDVCTLRMQLFIGPRAICHYKNHI----ILLTKADTEDI 461 
XP_003766113  389 QFLHVITSNNLQCFTVRCSAAAARDADPYVDTTLKACPPVSLDICALRMQLFIGLKAICHFRNHI----ILLTKAGTEDI 464 
ELK00543      359 QFLHVITSNNLQCFTVRCSAAAAREEDPYVDSTLKACPPVSMDVCALRIQLFIGLKAICHFKNHI----ILLTKADPEAI 434 
4_pfamImport  125 DDNQALTVGSLGSFTVQKQPGVVERGRGYMDTTLKACPPISMDVCALRIQLFIGLKAICHFKNHV----ILLTKAEPEAI 200 
XP_015216138  382 LFLHVITRNALMCFSVRCGAVAARCLDPYIDTMLK-------VRTLRPISLCCS-ESK---DQKIlsgiFLAVGIEPSSS 450  spotted gar
XP_019202713  467 EetERSTQRRglelkehnmltgiflavgidpattpalesllsrpllSRRWTMSSTKESSAAGHGWNVYVVDTVPPFTLYQ 546 
EEN52758      528 ----------------------------------------------------SPRTQRVAGQSHWSLYALQNASVGQLYK 555 
EFN72601      586 --------------------------------------------------------------NSWTMYSLNLPKLENIYF 603 
XP_006007914  454 -----REGGRg-----------------------------------lRRKSSKMAAGKQESEPGWNLYIVNTVPTIQLYN 493 
XP_012818776  447 E--ERRVSTSq----------------------------------rQRSKKPVKNKTAQDAEPNWNLYVVSTTPTVQLYK 490 
XP_015147341  462 T--ERRKPSRrm---------------------------------lSRKADSNKSRTNSESEPGWNLYIINTVSTIQLYR 506 
XP_003766113  465 P--ERRKLSKsl---------------------------------lSRKDGSIRHKSPSAMEAGWNLYIVNTISTVQLYK 509 
ELK00543      435 P--ERRESPKkl---------------------------------lSRKGTSVKLKTSPVAEAGWNLYIVNTISPVQLYK 479 
4_pfamImport  201 P--ERRDSPRrl---------------------------------lSRKDTSGKSKIPPVAEAGWNLYIVNTVSPVQLYK 245 
XP_015216138  451 PglESLLSKAy----------------------------------lSKKLAAPRPKEPEETSHGWNLYLISTVPAVQLYR 496  spotted gar
XP_019202713  547 EMVEYSQRYAETNpqAQSLRHLLSEAHLLLRAA----------LLHasdeQQTGPGgpadhrtdrqVLEEALRENCAQLG 616 
EEN52758      556 DMLDLGLRYQNSS--PPAYHQLLCEGHLLLRQA----------LFSqeagSRTQ------------QLQDLLCESCGLLG 611 
EFN72601      604 DILNAAKNHKSSS--PSTYRHLLGEAHTLIRLAkdisndpdneELDdtmhKNDL------------KLKNLYNQSCALLA 669 
XP_006007914  494 EMVEYCKKYETAN--PQSYRHLLSEAHMMVRAA----------LMDcslkESPEKE----------ELMVAFRESCAKLG 551 
XP_012818776  491 EMVEYSKRYETAK--TQGSIHLLNEAHLLVRAA----------LMDpnleESLAKT----------ELVAAFKESCAHLG 548 
XP_015147341  507 EMVDYSRTYENVR--TESCIHLLSEAHLLVRAA----------IMDrsffKSDEKE----------ELLRAFRESCALLG 564 
XP_003766113  510 EMVDYSKTYKNMR--TQSCIHLLSEAHLLVRAA----------LMDpcltEPGEKE----------ELLEAFRESCGHLG 567 
ELK00543      480 EMVDYSNTYKTAK--TQSCIHLLSEAHLLVRAA----------LMDgsqlEPGEKA----------ELLDAFKESCGHLG 537 
4_pfamImport  246 EMVDYSNTYKTAK--TQSCIHLLSEAHLLVRAA----------LMDasqlEPGEKA----------ELLEAFRESCAHLG 303 
XP_015216138  497 EMVEYSKKHESANlhSQSSLHLLSEAHLLLRAA----------LLDptasGPVDKE----------ELQAAFQESCALLG 556  spotted gar
XP_019202713  617 DSF----SRGS-QkECHLALPYYRMSGLSLTEVMSRNRPFPGSPS-----SYGPGFLFYLKHFLL--EDSEQTLSQEAAD 684 
EEN52758      612 DYH-----SLPdSqDWTLALPYYNMSGLKMAAIVQQ--ALHQMQPdreqpGYGRGLVHFLDHVLFi-GDEPLETDKSTSN 683 
EFN72601      670 DYY----IRSEiEsDWDLCIPYYKMSGLKPSEVLSR--KCSQDAP---------GLLTFLTDALFtmKSGPEADALFQGY 734 
XP_006007914  552 DTY----CRAD-EkHFHLALPYYRMSSLTMADIVKRGMHVEKSGM------FGNGFMFCLRHLLQ--EEITEVLSEETAA 618 
XP_012818776  549 DWF----SRLG-TkHSHLALPYYKMSCLSISDIINRVVGMEMLPG------YGRGFLFYLKHVLF--EEQDEQLSEAVAV 615 
XP_015147341  565 DCY----SRFD-TkDYHLALPYYRMSGLSVTEVLERRVSESDEIQ-----AYERGFIFYLTHSLN--EELNEELSKELAD 632 
XP_003766113  568 DCY----SRLD-TqYSHLALPYYKMSGLSMTDVLTRIDSVVEDGSq----NAERGLLFYINHSLY--ENVDEELSEELAA 636 
ELK00543      538 DCY----SRLD-TqYSHLALPYYKMSGLSMAEVLARVDWAVEDGSq----KYERGLIFYINHSLY--ENPDEELSEELAA 606 
4_pfamImport  304 DCYnflpSRLD-TqHSHLTLPYYKMSGLSLAEVLARVDWTVEDMSq----KYERGLIFYINHSLY--ENLDEELTKELAA 376 
XP_015216138  557 DCY----SRFH-KrDSHLALPYYKMSGLSMTEIINRNLEFPRSSE-----SFGKGFLFFLKHALD--EETTEELSTETAD 624  spotted gar
XP_019202713  685 EVIDIFSQSEHLML 698 
EEN52758      684 IVLEAYSQLEPESL 697 
EFN72601      735 NIIEIICKLEKEDL 748 
XP_006007914  619 NVLYIFSVADPHQL 632 
XP_012818776  616 KVIEIFNAVDKAQL 629 
XP_015147341  633 KVLQIFYLADPVQL 646 
XP_003766113  637 KVSQIFSAAEPKQL 650 
ELK00543      607 KVVQMFHVAEPKQL 620 
4_pfamImport  377 KVVQMFYVAEPKQL 390 
XP_015216138  625 KVLEVLGAAEPSQL 638  spotted gar
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