Conserved Protein Domain Family
WASH-7_C

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pfam14746: WASH-7_C (This model is not part of the current CDD release)
WASH complex subunit 7, C-terminal
This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes. The C-terminus is predicted to include a transmembrane region.
Statistics
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PSSM-Id: 521412
Aligned: 29 rows
Threshold Bit Score: 169.354
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_067738577        1177 TVVAARNLDSVISTLAKNFSENNDYFKVLVKVFQDVTA-------------SDEQKHLVNFYTIIPALTINYVETTVQAK 1243
WGS:AAQB:GK16118-PA  933 TENSIREYGKSVGHMMECYSDCTNYFKLLMQGFQPFFC-------------NPHNHHLKSFFLITPALIMNYIDYRVKEK 999 
EDV95255             887 TTGSIREYEKSVEHLKECYSDCTNYFKLLMQGFQPFLC-------------NPHNHHLRTFFLITPALIMNYIDYRVKEK 953 
Q9VXH9               929 TEGSIREYEKSLGHMKECYSDSTNYFKLLLQGFQPFLC-------------NPHNHHLRTFYLITPALIMNYIDYRVKQK 995  fruit fly
5_pfamImport           1 TVRTSWRLEN-------------EFFRLLLNAFDGLRRrrpthadgessapADSFAHLELFYLIIPPLTISYVEAMLKAK 67  
XP_001565426        1179 TVDAVANLDRVVHSMLEQLSDGSQYYPLLLDAIGRRLRhs----------lAERYAHLHLLYLLVPALANLQVAYTIQEK 1248
Q385H7              1051 TTQAVQVVDGVIGSMREKLSDGSAYFRMLLEAVTKRLKg------------AVKYTHLKNFYLIVPPICVLHVETMIREK 1118 Trypan...
Q4DZI5              1009 TVEAVRVVDSVIHNMRMKLSDGSEYFRMLLEAVTKRLKd------------ADKYEHLRNFHMIIPPICVLHVELMIREK 1076 Trypan...
A0DXK0              1013 TVSTAKELEEIFTQYKSSFSEKIDYINLLLKAFSSIN--------------TPENEHLSLFYLIVPTLTLNFIEKMLISK 1078 Parame...
XP_001020690        1009 TTKAAKELDDILLQLKSYFSSGTDYLKRIVSTMSKYAQ-------------SESQNHFTNFHILVPCLTLNYVTHALICK 1075
XP_067738577        1244 DLMYKNTRRRESyF--SDDGFAIGVAYILAILDQGEQFDALHWFEEVARKYKVEEEAYNEKQAEREARKREqaakkqket 1321
WGS:AAQB:GK16118-PA 1000 MKIYKKDQPKCS-L--FEDGFAIGLVYILNMLNQLSDFHELGWNQTTTQQLNSERQKLRQMLETQKTTEASsssssssas 1076
EDV95255             954 LKMYKKDQPKCS-L--FEDGFAIGLIYILNMLNQLGDFHELGWSQTTAQQLAAERFKLNDMLSTSSKDQSNspqk----- 1025
Q9VXH9               996 LKIYKKDQTKIS-L--FEDGFAIGLVYILNMLNQQTEFHELGWSQTITQHLNAERSKVRDILAGQQRTAPEq-------- 1064 fruit fly
5_pfamImport          68 ETIAKKDR-HGT-FlpTDDGFVMGLSYLLTLLNQTAAFNSLHWFKEVHTKYAREMGKLNQQTAGGTSNPLQqtst----- 140 
XP_001565426        1249 EKLLKKHKEEGV-F--SDDGFAVGTTFLLVLFRAYDPFDALHWFENKKTQYRGRLEAVQAALSAATASGSPe-------- 1317
Q385H7              1119 EQLVKKNK-DGI-F--TDDGFALGCSFLLKLFGVWNLFDSLHWFENIRKHYGSHLQEVREGIARHEQKMKAskna----- 1189 Trypan...
Q4DZI5              1077 EQLVKKNK-DGI-F--TDDGFALGCSFLLKLFGLSDLFESLHWFESVGKHYVERLLTMQEGIAERTKEAQKrkkpqr--- 1149 Trypan...
A0DXK0              1079 DQIGKKNSTTEV-Fi-SDDGFILGIQFFLTLLDQKGQFESLHWRKEIKNKFNIDLKSAKTLATTKPNQSQRa-------- 1148 Parame...
XP_001020690        1076 DKIPIKNNVNA--Fl-CNDGFIIGIAYILKLYNLEEKFHLIHWQEEVRKVYKEELESIKEISQADTTQISTh-------- 1144
XP_067738577        1322 taelidDEEEVHTLQLTAKRIELNRREFDLLDWSLNGARIFFK 1364
WGS:AAQB:GK16118-PA 1077 spnniqNEKLLQTVAISERHVNAYEQEYNLLYATLSSAEIFFQ 1119
EDV95255            1026 --phniDEKLLQTVAITERHVNAFEHEYNLLYATLSSAEIFFQ 1066
Q9VXH9              1065 -----lDEKLHQTVAITERHVNAYEHEYNLLYATLSSSEIFFQ 1102 fruit fly
5_pfamImport         141 --mepsDEKMLPTVSLTRKRLNAMQHEFELLQYNLSSSKIFFK 181 
XP_001565426        1318 ----------fDNFHLTFSTLQTHLKEYTGLENAFTSSRRFFD 1350
Q385H7              1190 --avcwEEEV-NNMHLTSMMLECSLGEYTALEEAFVSSKVFFy 1229 Trypanosoma brucei
Q4DZI5              1150 rdasheEEEI-NNMHLTATMVDYAIREYTALEEAFVSSKVFFH 1191 Trypanosoma cruzi
A0DXK0              1149 ------TDEINMQKELSLRKLNMQYDEFQMFFYAFNSCKILFl 1185 Paramecium tetraurelia
XP_001020690        1145 -----rLQQMQLENGLSIKKLESNLYEYNMFFNTFQACKILFR 1182
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