Conserved Protein Domain Family
WASH-4_N

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pfam14745: WASH-4_N 
WASH complex subunit 4, N-terminal
This entry is the conserved N-terminal region of proteins that form subunit 4 of the WASH complex, also known as subunit 7 or KIAA1033/SWIP. In species such as Drosophila this protein is the only component of the 'complex'. This complex is present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerisation. This domain comprises the WAHD1 and the TBR (tubulin-binding region) domains.
Statistics
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PSSM-Id: 494522
Aligned: 15 rows
Threshold Bit Score: 504.563
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015795193          23 GSFLNEFDSKLEELHKV----------------NLQYTYSSIVYGSYfnpgl-detvhERTEFVDILRTcGNMELNRVLL 85  
XP_002431643          28 GKFIEKHTNKLRSIEESfte----------snkNFGYDPINVKLNGW-----------EQIELINLINT-DNKILNKVVL 85  
XP_009021212           8 eSFVNDFTANLHNLQIStdvfs-------htvwDIVLNPIALTFHPN-----------ELASIDELIET-DNIIFDKILR 68  
XP_003294299          35 NQFAVDYAQQIWRIEEAlddtl-------nevwDINIDPLSIYNKPY-----------EQQDLIELVKT-DHKIFNKVML 95  
XP_020432546          43 NQFAVDYAQQIWQIEEAldetl-------sessDLNVDPVSLYIRPY-----------EQQDIIELIKT-EHKIFNKVML 103 
XP_023487583          32 GKFLEEYTSQLRRIEDAlddsi-------gdvwDFNLDPIALKLLPY-----------EQSSLLELIKT-ENKVLNKVIT 92  
XP_002111834          31 NEFLGEYTDHLKAIQEAlshsl-------sdawDFTMDPASLHILPY-----------EQASLTQLIKT-DNKILNKVMT 91  
XP_001020690          46 sqqfnNYIQKTKDLDQKy--------------------qIPLGDTPFnilhlnvnqqvQKQGLFDVNQT-DNPFYDKVSA 104 
WGS:AAQB:GK16118-PA   11 GAFIEEHDAHLDKLKTAispggndkltaatvslSLVAPPVEMNYGN------------ANFMISEMNAEaAELLANKPLT 78  
XP_002055003          18 GTFMEQHDEKMQLLQKQmlnnnsldeiggcqllTSVAPAIEINCIES-----------HLISASNLKFSeAELLANKPLT 86  
XP_015795193          86 VLSSLCHEMNNLSQIGLKdFIHIIALYGEdkkkadwkndttkakeSNDEAGdeLFSMSKLLPTLFKLLCFIKRCREVVHN 165 
XP_002431643          86 VLASLCMEVKERREEGYSkFCNALLKYGEe--------------cSNDDEKilHITISNYLPLFQDLYCFVNRCHQIVIE 151 
XP_009021212          69 VFASLCIEIQTLEREAVEnFYLQLIFYGEgd------------ehAEKQDGdiHLQIGRMLPILVGLYKYVGRCTDVLRN 136 
XP_003294299          96 VFSSLCNQARILKETAESkFYQPLTVFGEit--------------geSSEGdvQIEVGKLLPFMIDLSAFVNRCYSLIRN 161 
XP_020432546         104 VFASLTNQIRILKETAELkFYQPLIVFGEit--------------geASEGdvQVEVGRLLPFMIDLSAFVNRCYAITRN 169 
XP_023487583          93 VYAALCCEIKKLKYEAETkFYNGLLFYGEga------------tdSSMVEGdcQIQMGRFISFLQELSCFVTRCYEVVMN 160 
XP_002111834          92 VLAAVCCEIKRLEYEAKNeLYPALVLYGEge------------deEQQQIHeaYMKMGKMLSVLQHLTNFVGRCGDVLKN 159 
XP_001020690         105 TFTYLDTEIGKITEVFESkILNVISMYGEralddf-----qdeeeFPLLDGqaEFEISKLSPIFKQSLDLIKKIMGILHN 179 
WGS:AAQB:GK16118-PA   79 TLANLCNQCHDLTTALKQ--YQLAFSFGDfqi-------------deGGIEqtLHRMSSAIDFYCQVYFVLKRSIVILQN 143 
XP_002055003          87 TLANLCNQCNDLSKSADQ--LQLKFLNAGtqienlq---islgisPNMGLEhiLCKMSSAIDFFCQIYFLLKRIIVVLQN 161 
XP_015795193         166 LAIQMQELFTrnngkkvnsrsgIEVNDVRFDALFQHLGQLAVTIVNIEEILCSQTSLRKDFINFKRTFEIVIAKYDDFQL 245 
XP_002431643         152 IIKQLAAIYTtsdk-----nltINSMNVHFEDMMDHLGEILTILVTLDRLIESIDNISEGWSLYKRLIRTV-----QLNV 221 
XP_009021212         137 CLLQLCIFYTnesa----sirsMDISGSNLTVVYEHIGQLMHHLAVLDHVIDNQTLLKEHWKMYKRMIKSVYSSPESVKV 212 
XP_003294299         162 IISQFASIYQnqkni---htqfFK--NVHLQTVYYSMIDVFSVLVTLDSIITQNTALNSSWGRYLRMVKSVRQEPGKYSV 236 
XP_020432546         170 VVSQLASCYQnqtta---ftkfFK--NVHLQTVFYSLADLFTVLITLDQVVTQNQALSSSWGRFQRMVKSVRAEPGKYGV 244 
XP_023487583         161 VVHQLAALYIsnki----apkiIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGI 236 
XP_002111834         160 VVQQLAMLHQgkks----mnavMNVHGVHFEPVYEHLGDLLTILITLDEIMDNNNVMIQHWQLYKRMIKSALADPQRYDI 235 
XP_001020690         180 LINQLNIIYYkkndl-----hknifKNVELNSVFQTIGKGLSVVYVLDCAINQNKKIRDHWNVYKRMIKIIQTEPSKFGS 254 
WGS:AAQB:GK16118-PA  144 LWNQISASVCl----------pVDIGEVHLFTTFDSICELLEQIVIFNEI-SMQSNMSEKWTLYKKWLKNLDKSKANDLT 212 
XP_002055003         162 IWTQITSYVAi----------aVDVNEVHLFNVFDAMAELMEHIVIFNEL-TEQSNLSNKWSFYKKWLQTLAKNNEIFQH 230 
XP_015795193         246 QayDhQKMKVLHSLTVQIEKEIIDGNLFSQIIDA--------------------IKSTSSESSpdqliicdHLALYIKNA 305 
XP_002431643         222 I--P-EKLSMLENITKTLESNLLSGKIFHNMLEKlsq--------------isqIVRQSKLGD--------EFLLYLKNM 276 
XP_009021212         213 N--S-DQMQQFIVMLNRVDNVVMQGSMFQTCINQkfeep----------efsinVSTNKHFSD--------ECMAAVKEL 271 
XP_003294299         237 Q--EdEKLWQLEKLLLSLKGQLLEGFIFQTCITQefdfp-----------gvieVKSNKVLKQ--------EFCYNVKLL 295 
XP_020432546         245 A--EeERLFQLEKLLLSLKGQLLEGYIFQSCVQQefdfp-----------gvvdVRNNKQLKA--------EFSLNVKSI 303 
XP_023487583         237 Q--E-EKLKPFEKFLLKLEGQLLDGTIFQACIEQqfdsl----------nggvsVSKNSTFAE--------EFAHSIRSI 295 
XP_002111834         236 D--S-AKLRQLDKLVNRIDGKVFNGVIFKSCVTRafdd------------gfvsVTRNGAFEE--------EFRANLLSY 292 
XP_001020690         255 D--P-KTVKRFEKNIARLDKTVLSGACVQAVLEQnydanksftsdqlkqqnlclLAKNKDLIE--------LFENYFKQQ 323 
WGS:AAQB:GK16118-PA  213 GlyTkLEIGGLYASLDDLE-TVISGNIFRILLDSll-----------------eLKKQFNLKDvnh--ltqHSNAYTRKL 272 
XP_002055003         231 C--TkFEIDGLETSLDDIE-TVITGNIFRIFLQSll-----------------dTKRQLNLKDanvnyitqHSNAYIRKL 290 
XP_015795193         306 VQFHE---GNTNPIk---dDKKWLAINALLAIYVRTSK-REDRKLIKMVFDSQKKINAlyIHLKGNCTIFPDKFLNKQLL 378 
XP_002431643         277 LTRLEgkdLDMNQMmmnhqEKLWSKVICLFVLNTYLFG-LHDKKLLKQIWEVSKKNVC--INLFKNIIWFPDDFLFQHLS 353 
XP_009021212         272 WSRVDqkiGEVSEMn---eRARLIGVLCLFVLHQSVFQ-SQDKKMFKTLFDVHKKIPC--LVLTGSSVFYPSEFLARMLP 345 
XP_003294299         296 FGLLSakiMDSSELn---lRERFPGFLGLYVFYISLFKdITDKSFFKLVWEITKRVPM--VSIYANVFWFSGDFIQTLLP 370 
XP_020432546         304 FGLLSakiMDSSELy---lREKFPGMLGLYTFYISIFKdITDKSFFKQVWELTKRVPM--VSIYNNVIWYPADFIATLMP 378 
XP_023487583         296 FANVEarlGEPSEId---qRDKYVGICGLFVLHFQIFR-TVDKKFYKSLLDICKKVPA--ITLTANIIWFPDNFLIQKMP 369 
XP_002111834         293 FKRTEq-sNAAEEId---qRDNIIGICGLLVLHYHVFN-LVEKKMVKSILEYAKKIPG--VHVVGNIVWFISDFIINHWP 365 
XP_001020690         324 VVFYNdilDTTSEVq---eRKDLLYFLCTYAFFRKVFPeEQDKKIYKSLWTLQKKSPV--LEGHTHIFCYVYKFL-RYVC 397 
WGS:AAQB:GK16118-PA  273 QLEIEs-rHQANEYrnyeePKHIIRLTAFVAILYQLGI-QIEGKLMKHLLETLSKYHR--LPINQNVHWSPNVFLMQHAK 348 
XP_002055003         291 MSSIEv--nQANEYknyeePKHLLRLTAFICVLHKLGI-LLDGKLMKNALDTLNRYQR--VPLSRNVYWSPHAFICKHAK 365 
XP_015795193         379 KSrv----dkKMIEYFKQTRESTLK---IDLTEKVKSLNIKVNLWMLKFD------------DLLSEiEETTn------- 432 
XP_002431643         354 HIfka--ddkKQKQSIVNLRNEHLNqkdANLFNQVQKYLQETCLWVIQLN------------SVLKK-DK-Gn------- 410 
XP_009021212         346 KLnqmv-vdkKTLQAMESAKLLNLQkmvQCLNLQLPAFEAGLAQWIVKLEgylmslpssltsSSVQL-SDp--------- 414 
XP_003294299         371 GMiki--vgnPN---IMELRKEYLKtvdKEFAPRVKSYYLQVSRWMVRME------------SSIAR-TS---------- 422 
XP_020432546         379 GMiki--vgnPD---IQGARREYLKivdKEFAQRVKSYYLQVSRWMVRME------------SGSLN-NRg--------- 431 
XP_023487583         370 AAakl--ldrKSLQAIKIHRETFLQqkaQSLTKDVQSYYVFVSSWMMKME------------SILSK-EQRMd------- 427 
XP_002111834         366 PAsnsknldrKLITMANAAKSSYLTsasQSLSRDVQQYHLLVSTWMVQME------------SELLS-RDk--------- 423 
XP_001020690         398 PLsksttldpKEPEQFTKL---YVQdldIQIPKKINTFYEDFCYWISRME------------SILTSnTALAtgdkskrd 462 
WGS:AAQB:GK16118-PA  349 SLirtp-gnkVPTSL--QPNAVSLEkikQNDQRACRQLGTQIAIWSLNMQ------------------RVFAa------- 400 
XP_002055003         366 TLvka--qdkVQDCL--KQYYASMEkinANDLRNCRQLGNQIALWSINMQ------------------RVFAa------- 416 
XP_015795193         433 ----dFIEILHKQIKVIEEGLDLALQCSSIGKNHIYQHNYAKKSLCKSDLIAVCKLTAILKGIELSFLRRKGEILQILAR 508 
XP_002431643         411 ----lILDELKEKCKLFLAGSKLASDMSRVLKTVLNLHTALSKPMTKATVLYLCKLIELLKSIEMIYQNYYFFMCEPLNH 486 
XP_009021212         415 ----rFNEELIEKCKLLQQGLIQSFYLRNTSATLLTTHATLNRPMTKSLVNNICHVVEMLKVIEGSWYRFSIQVVNTASY 490 
XP_003294299         423 -----HWDASLSKVNQIIQGVVLSYHISHLLKTMIGLHMNLTAPLKPSDVRKLFQCAEMLKSIQNTFHRRSAMISAHISM 497 
XP_020432546         432 ----gFWDANLSRIGQIIQGILLSYHISHLFKTMIGLHMSLTAPLKPSDVRRLFQCAELLKSIQGTFHRRTAMISAHISL 507 
XP_023487583         428 ----kFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLK------------------- 484 
XP_002111834         424 ----eTSADLNRRYKLLVQGVTFANKLSLLVRAVLNMHIVLGKPMSKSSVLSICRVVEMLKAIDHTFHRRSVVIAESINV 499 
XP_001020690         463 rsikiVEEYTSYRVRLLIKALQMASQIKQMITTNLMLHINEGIGFTPQLIKYVVKGIVMLKAIESVYISKIEAFQPHM-- 540 
WGS:AAQB:GK16118-PA  401 ----gIFGHLKSFSELILSGQSYADQVAGHIEGLVNRHVALMVPLTKTDFYTICKLMQYLKVIHHTFASNQISFIRFLSS 476 
XP_002055003         417 ----gTFGQLKSFSKLLLLGQGYAAQVNGLIDSLIKRHLALGLSISKVTLFTICKLMQYLQILQKTFANNQILCIRFLSS 492 
XP_015795193         509 STQYYSYLILGALTSCKKRLiSEVKKYSEKKL---DVLSAIILGSNCIHGPIlTLERQILASLCFSIA-----NQSMNEN 580 
XP_002431643         487 IRQYLAYLALNTIKNAKSRI-LSDKSYTKKHL---DTLSALVLSEKVLLGPV-TVERCLIARLGLS-IargnaSKALKDE 560 
XP_009021212         491 LVQYFSLLMAVVISNANKRV-RGDKKV---RP---EVLSAFELMLQCLAGPM-TNERILAMKLALG-Fcv--kNKAFKDD 559 
XP_003294299         498 MVQQLTDIINEKLNVVRAKY-SGRTNYSEIEL---DVIVALSLVSDLLCGVA-TPERITVIRLCLN-Viy--qSNALKEQ 569 
XP_020432546         508 MTQQLTTIITNKLDVVRARY-TGKSNYSDTEL---DVIMALTLTSDLLTGVV-TPERLIIIKLCLN-Viy--qANLLKDP 579 
XP_023487583         485 -----------------KRV-ISDKKYSEQRL---DVLSALVLAENTLNGPS-TKQRRLIVSLALS-Vgt--qMKTFKDE 539 
XP_002111834         500 VIQFVVYFLLKAIEKSKKRL-RSDKKYTEARL---DVLSALILAQNALNGPG-TKERILICRLAIC-Val--qMRCFKDD 571 
XP_001020690         541 LLKTLVKQLLLILGATYEKL--TKADYKQKKPlynEFRAAIQNVIKNLRGPI-TSLKISTMEFALNFIi---sNYITEKK 614 
WGS:AAQB:GK16118-PA  477 LSQWQKQKVLHLLLTTKKKI--VDLKLLQRKM---NILSSLKLTEKSLRSHP-VRRRLTVINLALSEFle--kDRSLPAD 548 
XP_002055003         493 LLQWQKQKMQHLLLLTKKSI--VDLKLMQRKM---NILYTLKLSEKSIKGYP-TKRRLTIVNLALSEYlg--kDRILPAD 564 
XP_015795193         581 ELAKVYSGFKRIRSYCLIFKRLQDW 605 
XP_002431643         561 EVEQIYLNLQLLNKICLLQKTVTES 585 
XP_009021212         560 ELVSIRVYLEDIDRFTNFKTLIQES 584 
XP_003294299         570 EIEELRLHIKRLEFISDLGSIIKSS 594 
XP_020432546         580 DMEELRLHVKRLEFVSDIHASIRRV 604 
XP_023487583         540 ELFPLQVVMKKLDLISELRERIRTQ 564 
XP_002111834         572 ELSFIIGLTKALDTLANLGHR-QEA 595 
XP_001020690         615 EGQDIKFIFWKIKTVSQFQYNISKA 639 
WGS:AAQB:GK16118-PA  549 KQKLFKSIYQRANNLGDIQRNISGQ 573 
XP_002055003         565 KQKLLKSIALRANNLCRLQQNMLGQ 589 
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