Conserved Protein Domain Family
WASH-4_N

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pfam14745: WASH-4_N (This model is not part of the current CDD release)
WASH complex subunit 7, N-terminal
This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Statistics
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PSSM-Id: 494522
Aligned: 15 rows
Threshold Bit Score: 504.563
Created: 22-Aug-2024
Updated: 4-Feb-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015795193   23 GSFLNEFDSKLEELHKV----------------NLQYTYSSIVYGSYfnpgl-detvhERTEFVDILRTcGNMELNRVLL 85  
XP_002431643   28 GKFIEKHTNKLRSIEESfte----------snkNFGYDPINVKLNGW-----------EQIELINLINT-DNKILNKVVL 85  
XP_009021212    8 eSFVNDFTANLHNLQIStdvfs-------htvwDIVLNPIALTFHPN-----------ELASIDELIET-DNIIFDKILR 68  
XP_003294299   35 NQFAVDYAQQIWRIEEAlddtl-------nevwDINIDPLSIYNKPY-----------EQQDLIELVKT-DHKIFNKVML 95  
XP_020432546   43 NQFAVDYAQQIWQIEEAldetl-------sessDLNVDPVSLYIRPY-----------EQQDIIELIKT-EHKIFNKVML 103 
XP_002401323   27 GKFMEEFTTQLRSIEQSldeti-------ceawDMESDAVSLQHLPY-----------ENTTLLELIST-DNKILNKVIT 87  
XP_023487583   32 GKFLEEYTSQLRRIEDAlddsi-------gdvwDFNLDPIALKLLPY-----------EQSSLLELIKT-ENKVLNKVIT 92  
XP_002111834   31 NEFLGEYTDHLKAIQEAlshsl-------sdawDFTMDPASLHILPY-----------EQASLTQLIKT-DNKILNKVMT 91  
XP_001020690   46 sqqfnNYIQKTKDLDQKy--------------------qIPLGDTPFnilhlnvnqqvQKQGLFDVNQT-DNPFYDKVSA 104 
XP_002067587   21 GAFIEEHDAHLDKLKTAispggndkltaatvslSLVAPPVEMNYGN------------ANFMISEMNAEaAELLANKPLT 88  
XP_015795193   86 VLSSLCHEMNNLSQIGLKdFIHIIALYGEdkkkadwkndttkakeSNDEAGdeLFSMSKLLPTLFKLLCFIKRCREVVHN 165 
XP_002431643   86 VLASLCMEVKERREEGYSkFCNALLKYGEe--------------cSNDDEKilHITISNYLPLFQDLYCFVNRCHQIVIE 151 
XP_009021212   69 VFASLCIEIQTLEREAVEnFYLQLIFYGEgd------------ehAEKQDGdiHLQIGRMLPILVGLYKYVGRCTDVLRN 136 
XP_003294299   96 VFSSLCNQARILKETAESkFYQPLTVFGEit--------------geSSEGdvQIEVGKLLPFMIDLSAFVNRCYSLIRN 161 
XP_020432546  104 VFASLTNQIRILKETAELkFYQPLIVFGEit--------------geASEGdvQVEVGRLLPFMIDLSAFVNRCYAITRN 169 
XP_002401323   88 VLAALCAEAKHLCHEAKTrFHSSLLFYGEgsl-----------asNNVPDGepQVAVGRMVALMQDLSCHVSRCYLVAKN 156 
XP_023487583   93 VYAALCCEIKKLKYEAETkFYNGLLFYGEga------------tdSSMVEGdcQIQMGRFISFLQELSCFVTRCYEVVMN 160 
XP_002111834   92 VLAAVCCEIKRLEYEAKNeLYPALVLYGEge------------deEQQQIHeaYMKMGKMLSVLQHLTNFVGRCGDVLKN 159 
XP_001020690  105 TFTYLDTEIGKITEVFESkILNVISMYGEralddf-----qdeeeFPLLDGqaEFEISKLSPIFKQSLDLIKKIMGILHN 179 
XP_002067587   89 TLANLCNQCHDLTTALKQ--YQLAFSFGDfqi-------------deGGIEqtLHRMSSAIDFYCQVYFVLKRSIVILQN 153 
XP_015795193  166 LAIQMQELFTrnngkkvnsrsgIEVNDVRFDALFQHLGQLAVTIVNIEEILCSQTSLRKDFINFKRTFEIVIAKYDDFQL 245 
XP_002431643  152 IIKQLAAIYTtsdk-----nltINSMNVHFEDMMDHLGEILTILVTLDRLIESIDNISEGWSLYKRLIRTV-----QLNV 221 
XP_009021212  137 CLLQLCIFYTnesa----sirsMDISGSNLTVVYEHIGQLMHHLAVLDHVIDNQTLLKEHWKMYKRMIKSVYSSPESVKV 212 
XP_003294299  162 IISQFASIYQnqkni---htqfFK--NVHLQTVYYSMIDVFSVLVTLDSIITQNTALNSSWGRYLRMVKSVRQEPGKYSV 236 
XP_020432546  170 VVSQLASCYQnqtta---ftkfFK--NVHLQTVFYSLADLFTVLITLDQVVTQNQALSSSWGRFQRMVKSVRAEPGKYGV 244 
XP_002401323  157 IVQQMSALFdksk-----pscvIDVTDVHFQTVFEHLGQMLASLVTLDEIVQAQSALREHWTLYRRMLKSVHHNCAKFDV 231 
XP_023487583  161 VVHQLAALYIsnki----apkiIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGI 236 
XP_002111834  160 VVQQLAMLHQgkks----mnavMNVHGVHFEPVYEHLGDLLTILITLDEIMDNNNVMIQHWQLYKRMIKSALADPQRYDI 235 
XP_001020690  180 LINQLNIIYYkkndl-----hknifKNVELNSVFQTIGKGLSVVYVLDCAINQNKKIRDHWNVYKRMIKIIQTEPSKFGS 254 
XP_002067587  154 LWNQISASVCl----------pVDIGEVHLFTTFDSICELLEQIVIFNEI-SMQSNMSEKWTLYKKWLKNLDKSKANDLT 222 
XP_015795193  246 QayDhQKMKVLHSLTVQIEKEIIDGNLFSQIIDA--------------------IKSTSSESSpdqliicdHLALYIKNA 305 
XP_002431643  222 I--P-EKLSMLENITKTLESNLLSGKIFHNMLEKlsq--------------isqIVRQSKLGD--------EFLLYLKNM 276 
XP_009021212  213 N--S-DQMQQFIVMLNRVDNVVMQGSMFQTCINQkfeep----------efsinVSTNKHFSD--------ECMAAVKEL 271 
XP_003294299  237 Q--EdEKLWQLEKLLLSLKGQLLEGFIFQTCITQefdfp-----------gvieVKSNKVLKQ--------EFCYNVKLL 295 
XP_020432546  245 A--EeERLFQLEKLLLSLKGQLLEGYIFQSCVQQefdfp-----------gvvdVRNNKQLKA--------EFSLNVKSI 303 
XP_002401323  232 A--P-EDLKALDKLMGQLEYQLLQGRIFMGCLEQgfdd------------tslcVAKNGAFAE--------EFALNIRNW 288 
XP_023487583  237 Q--E-EKLKPFEKFLLKLEGQLLDGTIFQACIEQqfdsl----------nggvsVSKNSTFAE--------EFAHSIRSI 295 
XP_002111834  236 D--S-AKLRQLDKLVNRIDGKVFNGVIFKSCVTRafdd------------gfvsVTRNGAFEE--------EFRANLLSY 292 
XP_001020690  255 D--P-KTVKRFEKNIARLDKTVLSGACVQAVLEQnydanksftsdqlkqqnlclLAKNKDLIE--------LFENYFKQQ 323 
XP_002067587  223 GlyTkLEIGGLYASLDDLE-TVISGNIFRILLDSll-----------------eLKKQFNLKDvnh--ltqHSNAYTRKL 282 
XP_015795193  306 VQFHE---GNTNPIk---dDKKWLAINALLAIYVRTSK-REDRKLIKMVFDSQKKINAlyIHLKGNCTIFPDKFLNKQLL 378 
XP_002431643  277 LTRLEgkdLDMNQMmmnhqEKLWSKVICLFVLNTYLFG-LHDKKLLKQIWEVSKKNVC--INLFKNIIWFPDDFLFQHLS 353 
XP_009021212  272 WSRVDqkiGEVSEMn---eRARLIGVLCLFVLHQSVFQ-SQDKKMFKTLFDVHKKIPC--LVLTGSSVFYPSEFLARMLP 345 
XP_003294299  296 FGLLSakiMDSSELn---lRERFPGFLGLYVFYISLFKdITDKSFFKLVWEITKRVPM--VSIYANVFWFSGDFIQTLLP 370 
XP_020432546  304 FGLLSakiMDSSELy---lREKFPGMLGLYTFYISIFKdITDKSFFKQVWELTKRVPM--VSIYNNVIWYPADFIATLMP 378 
XP_002401323  289 FTQVDaklGETNELd---kRKQLIGIYALYVLYYYIYR-TIDKKFFKALWDVYKKVPA--VHILGNILWFPDQFLMLQMP 362 
XP_023487583  296 FANVEarlGEPSEId---qRDKYVGICGLFVLHFQIFR-TVDKKFYKSLLDICKKVPA--ITLTANIIWFPDNFLIQKMP 369 
XP_002111834  293 FKRTEq-sNAAEEId---qRDNIIGICGLLVLHYHVFN-LVEKKMVKSILEYAKKIPG--VHVVGNIVWFISDFIINHWP 365 
XP_001020690  324 VVFYNdilDTTSEVq---eRKDLLYFLCTYAFFRKVFPeEQDKKIYKSLWTLQKKSPV--LEGHTHIFCYVYKFL-RYVC 397 
XP_002067587  283 QLEIEs-rHQANEYrnyeePKHIIRLTAFVAILYQLGI-QIEGKLMKHLLETLSKYHR--LPINQNVHWSPNVFLMQHAK 358 
XP_015795193  379 KSrv----dkKMIEYFKQTRESTLK---IDLTEKVKSLNIKVNLWMLKFD------------DLLSEiEETTn------- 432 
XP_002431643  354 HIfka--ddkKQKQSIVNLRNEHLNqkdANLFNQVQKYLQETCLWVIQLN------------SVLKK-DK-Gn------- 410 
XP_009021212  346 KLnqmv-vdkKTLQAMESAKLLNLQkmvQCLNLQLPAFEAGLAQWIVKLEgylmslpssltsSSVQL-SDp--------- 414 
XP_003294299  371 GMiki--vgnPN---IMELRKEYLKtvdKEFAPRVKSYYLQVSRWMVRME------------SSIAR-TS---------- 422 
XP_020432546  379 GMiki--vgnPD---IQGARREYLKivdKEFAQRVKSYYLQVSRWMVRME------------SGSLN-NRg--------- 431 
XP_002401323  363 QVirs--ldkKAQDAVKMQRLNFLQqksASLSKDVQALHVQVSSWLLRME------------SAFQK-DTd--------- 418 
XP_023487583  370 AAakl--ldrKSLQAIKIHRETFLQqkaQSLTKDVQSYYVFVSSWMMKME------------SILSK-EQRMd------- 427 
XP_002111834  366 PAsnsknldrKLITMANAAKSSYLTsasQSLSRDVQQYHLLVSTWMVQME------------SELLS-RDk--------- 423 
XP_001020690  398 PLsksttldpKEPEQFTKL---YVQdldIQIPKKINTFYEDFCYWISRME------------SILTSnTALAtgdkskrd 462 
XP_002067587  359 SLirtp-gnkVPTSL--QPNAVSLEkikQNDQRACRQLGTQIAIWSLNMQ------------------RVFAa------- 410 
XP_015795193  433 ----dFIEILHKQIKVIEEGLDLALQCSSIGKNHIYQHNYAKKSLCKSDLIAVCKLTAILKGIELSFLRRKGEILQILAR 508 
XP_002431643  411 ----lILDELKEKCKLFLAGSKLASDMSRVLKTVLNLHTALSKPMTKATVLYLCKLIELLKSIEMIYQNYYFFMCEPLNH 486 
XP_009021212  415 ----rFNEELIEKCKLLQQGLIQSFYLRNTSATLLTTHATLNRPMTKSLVNNICHVVEMLKVIEGSWYRFSIQVVNTASY 490 
XP_003294299  423 -----HWDASLSKVNQIIQGVVLSYHISHLLKTMIGLHMNLTAPLKPSDVRKLFQCAEMLKSIQNTFHRRSAMISAHISM 497 
XP_020432546  432 ----gFWDANLSRIGQIIQGILLSYHISHLFKTMIGLHMSLTAPLKPSDVRRLFQCAELLKSIQGTFHRRTAMISAHISL 507 
XP_002401323  419 ----kLLEDLNRRSSLLLQGIYFGWYISHQVTTVMNLHVALSKPMTKSSVLLLGKMIEMMKAIEAMFHRQTVKICDSVTH 494 
XP_023487583  428 ----kFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLK------------------- 484 
XP_002111834  424 ----eTSADLNRRYKLLVQGVTFANKLSLLVRAVLNMHIVLGKPMSKSSVLSICRVVEMLKAIDHTFHRRSVVIAESINV 499 
XP_001020690  463 rsikiVEEYTSYRVRLLIKALQMASQIKQMITTNLMLHINEGIGFTPQLIKYVVKGIVMLKAIESVYISKIEAFQPHM-- 540 
XP_002067587  411 ----gIFGHLKSFSELILSGQSYADQVAGHIEGLVNRHVALMVPLTKTDFYTICKLMQYLKVIHHTFASNQISFIRFLSS 486 
XP_015795193  509 STQYYSYLILGALTSCKKRLi---SEVKKYSEKKL---DVLSAIILGSNCIHGPIlTLERQILASLCFSIA-----NQSM 577 
XP_002431643  487 IRQYLAYLALNTIKNAKSRI----LSDKSYTKKHL---DTLSALVLSEKVLLGPV-TVERCLIARLGLS-IargnaSKAL 557 
XP_009021212  491 LVQYFSLLMAVVISNANKRV----RGDKKV---RP---EVLSAFELMLQCLAGPM-TNERILAMKLALG-Fcv--kNKAF 556 
XP_003294299  498 MVQQLTDIINEKLNVVRAKY----SGRTNYSEIEL---DVIVALSLVSDLLCGVA-TPERITVIRLCLN-Viy--qSNAL 566 
XP_020432546  508 MTQQLTTIITNKLDVVRARY----TGKSNYSDTEL---DVIMALTLTSDLLTGVV-TPERLIIIKLCLN-Viy--qANLL 576 
XP_002401323  495 IIQHLSYVALFAVSNAKKRLvsdkVSDKKYSERRL---DVLSSLVLAEKCLNGPA-TKERRLIIHLAIA-Vgv--qMKSF 567 
XP_023487583  485 -----------------KRV----ISDKKYSEQRL---DVLSALVLAENTLNGPS-TKQRRLIVSLALS-Vgt--qMKTF 536 
XP_002111834  500 VIQFVVYFLLKAIEKSKKRL----RSDKKYTEARL---DVLSALILAQNALNGPG-TKERILICRLAIC-Val--qMRCF 568 
XP_001020690  541 LLKTLVKQLLLILGATYEKL-----TKADYKQKKPlynEFRAAIQNVIKNLRGPI-TSLKISTMEFALNFIi---sNYIT 611 
XP_002067587  487 LSQWQKQKVLHLLLTTKKKI-----VDLKLLQRKM---NILSSLKLTEKSLRSHP-VRRRLTVINLALSEFle--kDRSL 555 
XP_015795193  578 NENELAKVYSGFKRIRSYCLIFKRLQDW 605 
XP_002431643  558 KDEEVEQIYLNLQLLNKICLLQKTVTES 585 
XP_009021212  557 KDDELVSIRVYLEDIDRFTNFKTLIQES 584 
XP_003294299  567 KEQEIEELRLHIKRLEFISDLGSIIKSS 594 
XP_020432546  577 KDPDMEELRLHVKRLEFVSDIHASIRRV 604 
XP_002401323  568 KEEEISSFHSVMRKLDLIGELQEKLQEG 595 
XP_023487583  537 KDEELFPLQVVMKKLDLISELRERIRTQ 564 
XP_002111834  569 KDDELSFIIGLTKALDTLANLGHR-QEA 595 
XP_001020690  612 EKKEGQDIKFIFWKIKTVSQFQYNISKA 639 
XP_002067587  556 PADKQKLFKSIYQRANNLGDIQRNISGQ 583 
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