Conserved Protein Domain Family
WASH-7_mid

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pfam14744: WASH-7_mid (This model is not part of the current CDD release)
WASH complex subunit 7
This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Statistics
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PSSM-Id: 494521
Aligned: 29 rows
Threshold Bit Score: 349.975
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4QAK3        785 FLFFHReTLYPLFLKYCYEHtlaaV--SLPQIVSALGDCRLLIMSA-RHVK-------NPSETLLSDYVEFVRDCVHQ-E 853  Leishmania major
XP_650660     517 FLYFVRyPLLEKIYENIIKN----E--EFYESFIEFNKIYSFIIKNqSLQT-------IIVGDIYDALNNEIEVLIKK-I 582 
A0DXK0        649 YFYWCR-ELLPSFFQYIYQNpsqaK--RFQFLLNAVSDCSIQLKDC-MHLE-------NPDE-LFDSFRQYVVKEFYA-Q 715  Paramecium te...
XP_001020690  644 FLFWCK-DILPLAIKQFFENpsqsK--RLIYLSQAISDTLPIVKAT-LHLQ-------NPLY-MYETFKEEVITTFKD-E 710 
XP_006655765  618 FLYWRK-EMLATWLSMVYGDacklS--WLQSIIDAFSDGMSLLTLG------------NVGKVTLQCYEEEIEHALRK-E 681 
Q9VXH9        586 HWFLDT-SVLKEYTEL--------Q--RNPYSLQNLVSVS-------HHLD-------KIMAMFR---GSRCPKQSANdL 637  fruit fly
XP_002067587  593 YWLIST-SILKEYAQQ--------Q--RNPYALQNIIAAS-------NHLD-------KALTVFKCGGNGSTPRNSHD-L 646 
XP_042934267  497 FLFWHR-SFIAAYFSAIIEDn--nS--RPELFFDAINDIETILGSD-DSEQ-------NIK--VKESVREELYELYEK-L 560 
XP_002291545  481 CMYFYR-DLFPVFIENLYQTilnsSfgHTQLVLSALSDPERILKHA-SHLEid---elSGSTKSSIGYKNYLFGVVQE-E 554 
2_pfamImport    1 FLYFHR-HLFRLYFGTLLQErppiE--EITLTFLAITDCAVLAKRA-TERReekrkdeEKKDGILRSFQREIWTALRE-E 75  
Q4QAK3        854 LVQPLCTEIENQLRLRTHDA-----VLGQ----PYrvlrpsaeaagRDLTRYTLlQPFRFFDEWMHLEAQIEHYLSAQFY 924  Leishmania major
XP_650660     583 IVEPLQTQIEEDLRLQIYGEln--vNDVNivshPI-----------QDIQRIID-HPIIILNRCIHVKSEIENSLEIKFY 648 
A0DXK0        716 YLQPLARDIEDYLRIQVHTVliekiTALN----PFkq-------qvKDLKRLLDiDYVLIFDSIVNLRTEINQILNETFY 784  Paramecium te...
XP_001020690  711 YLTPLTRQIEDFLRIQIHAMlidkvVGKN----PFkd-------emNNIKKLLElEQIQFFDVIIDIKKEIQNQLNEKFY 779 
XP_006655765  682 VVAPLCRDIETDLRLHVHSThlkgaVFVN----PTkt-------gvRNLSWYLRmKPLRLPSKFIDIKLLVESHLNSAFY 750 
Q9VXH9        638 IIEFLSNHLEFFLRVEALSHlf--qSQDQ----PFqqsal-------dyrlCINaVAVENDGDYNIIKDHLENYFTATFY 704  fruit fly
XP_002067587  647 VIEFLSTHFESFLRVEALSHlf--qDQDQ----PFqqntl-------dyrsCTNvSAIEIDGQYNILRDNLENYFTATFY 713 
XP_042934267  561 YLKKLCETVETDLRLTVHSHlq--lDDRT----PKdpmh----danMRLVNLLElPAVQLFDRLIDIKRYVEKYLESTFY 630 
XP_002291545  555 YIDPICEVVEIDLRLTVHAKn----DQRQ----KAqttst-------rvhtFINaPPLYICQKKIDVKAEVEKYLEKTFY 619 
2_pfamImport   76 FMSGLCGEIENDLRVLSHKHlkvdeRDKT----PAek-------haFFTRLLKStMTLRILDRSVSVRDFVEEYLERTFY 144 
Q4QAK3        925 NLnalmpNDWKTYEEMRSLALRTYHLRIADSHLPSCILDQG-LDVLVITENIQQFVAYYTYNLNEQIFIQR-PSLtpSKH 1002 Leishmania major
XP_650660     649 KH-----YNWDEYQRMKVLGEKKYGLHLFENYLIGQTTVEG-LDVLRIMKNIQSFVMKYHYNLYSQCFIER-ESD--GNR 719 
A0DXK0        785 NInvlnmYDQETYEQMRSLANSKFGLNLINVYLPTQTVDQGnFDVLNVLKNIQQFFTKYTYNLYQQQFVQV-TSE--SKQ 861  Paramecium te...
XP_001020690  780 NLnvlnmHDMETYEQMRVLAKFYFDVNLINVYIPSQTIEQGqLDILQILRNIPTFVDTYTYNLHNQTFTQI-TTE--SKL 856 
XP_006655765  751 TYsvmsnYDNRMYAEMHQLGELKYGVELEDFHLSMDTVDLD-FYLKQSMENLDSFSEAYSYNIVKQMFVENdLGGqdRKN 829 
Q9VXH9        705 NLttiapHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQG-IDVLQIMRNIHTFASSYAYNMNLQVFVET-NSR--SKH 780  fruit fly
XP_002067587  714 NLttiapHDWKSYEKFRHFAYNLLQLRPVDDYLPNQTIDQG-IDVLQIMRNIHTFASSYAYNMNLQLFVET-DSK--GKH 789 
XP_042934267  631 NLtavalHDSNTYMAMSLLAKQKYNLILCQSRLPFQKLDQG-PDVLFIARNIDSFVENYDYNLNEQFFIEK-DSK--SKQ 706 
XP_002291545  620 NLctlslNDCNTYTEMRSIANERYGLCVMDPYLPDGNLEQS-VNFIDILRDLNSFVSKYNYNMIDQSFVEC-RPVlgAKF 697 
2_pfamImport  145 NLtavslHDAHTYTKMAMMAHFRYGLNPLDGRLPHSIVNQG-LDVVNVMKALNTFTATYNYDLYHNLFVEK-RSS--SRT 220 
Q4QAK3       1003 LHTLNTRHIANSIRTHGTGVMNTAVNYVYKYLLKKMAILSHFLHDDYVRSHLLKDARAMRQRKkeqq-pckYPVEQAEQL 1081 Leishmania major
XP_650660     720 LSSIGINQIAESIKTHGMGIMNTCVNYVYQYLLKQFTLLSEFLFDDQIKGILMKSLKTFDGKN--------YTLAMAELD 791 
A0DXK0        862 VYSISIQQIADSIRTHGIGILSTTVNSVYKFLQKKIQMFSQFLFDDLIQSPLVREDRFFREKKdel--dgqYPYDRAEAL 939  Paramecium te...
XP_001020690  857 VQTIGIQQISDSIRTHGLGILNTTVNSIFKYVAKKIEILSNLLYDELILQNLIREEKWFQENKmqi--dgyYPYERAKKL 934 
XP_006655765  830 LRILCVDHIASSAATCNLQRISAYLDSIFIFLNQMVVNLHALL-QSEIEIDLLRDFKQPEDIGms----gaNPASQGD-M 903 
Q9VXH9        781 LDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEQIKSRLLKELRFHTEHKhsks-yqsYPYERADSF 859  fruit fly
XP_002067587  790 LDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEHIKSRLLKEFRLHAEQKhnnkpyqsYPYERAESF 869 
XP_042934267  707 LTILTVEHVANSIRTHGMGIMHTTINHAYQFLKKKFYIFSQLLYDDRIRNQLIKDERYFHENAekl--ekmYPVSRAQRF 784 
XP_002291545  698 LFTFNTKCVSASMKQHGNGIVGSAINASYNLLGKKFQLFTQFMADENVKSLLSKEFRWLNNQKnec--sniYPFSRASAF 775 
2_pfamImport  221 LHILSWEHISNSLRMHGMGVVNTSVNLAYQLLRKKLSIVNEFLDDEHVKAMLSGETKYFEENRkql--kkmYPVKRAERL 298 
Q4QAK3       1082 IREMDRLG-V-------AHDGVSFLEKARQLISEMGNALGFMRMMRSGGLRAVAERARFVPlptTAAA 1141 Leishmania major
XP_650660     792 IKEFKRLG-LrkikhnkKVVSSSYLDLFRMLITFIGNSIGFVRMIRTGGLMHCAKTIEFIP---DLFN 855 
A0DXK0        940 YKEIKKMG-T-------FDDGTNYLDKFRTLITQIGNSLAFVRLLRSAALHVNSKCLEYVPsqyNPTQ 999  Paramecium tetraurelia
XP_001020690  935 SSTLKRLG-V-------SKEGNTYLDQFRIFITQIGNALGFIRLLRSASLNYCSKSIEFLPyqiDSED 994 
XP_006655765  904 KFSIGKLG-L-------GDHALDLLEQVKAVVTRIGSVLGLMMVLTAGRTRYLNNISRYVR---KPKC 960 
Q9VXH9        860 LKKIRRLG-C-------SSNGETYMDLFRKVITQVGNAVGYVRLLQAGSKNANFRNRSYKTrfdSNFS 919  fruit fly
XP_002067587  870 IKKIKRLG-F-------SNNGETYMDLFRKVITQVGNAVGYVRLLQAGSKNANYRSRSYMSrtySKLL 929 
XP_042934267  785 SASIRLLG-V-------A-DDDLYLDKLRILITEIGNVMGYVRLVRSGGVEASMQSLGFLP---NLDD 840 
XP_002291545  776 AQELKKFE-Le--------sGNTGLDECRNVLSEIGNIIAFVRMIRAAKRKIFGDEMAFLSpsvTVEE 834 
2_pfamImport  299 KNAMCELGrVg------GEEGETYFDRFRVTITQLGNALGFVRSMKAAADLVVSDALVY-----DREE 355 
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