Conserved Protein Domain Family
WASH-7_mid

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pfam14744: WASH-7_mid (This model is not part of the current CDD release)
WASH complex subunit 7
This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Statistics
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PSSM-Id: 521411
Aligned: 29 rows
Threshold Bit Score: 349.976
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4QAK3        785 FLFFHReTLYPLFLKYCYEHTLAAV--SLPQIVSALGDCRLLIMSARHVK----NPSEt--LLSDYVEFVRDCVHQELVQ 856  Leishmania major
A0DXK0        649 YFYWCR-ELLPSFFQYIYQNPSQAK--RFQFLLNAVSDCSIQLKDCMHLE----NPDE---LFDSFRQYVVKEFYAQYLQ 718  Paramecium te...
XP_001020690  644 FLFWCK-DILPLAIKQFFENPSQSK--RLIYLSQAISDTLPIVKATLHLQ----NPLY---MYETFKEEVITTFKDEYLT 713 
Q4DZI5        619 FLYWHReTFYPLFFERMYQRPLRSN--YLPYLLMAMHDCRTSILSSRHVE----DAHT---LLDAYISYIQKCIQNHLIK 689  Trypanosoma c...
Q385H7        651 FLYWQReVFFPTFIKRLYQKPLNSE--YMPYTILAMHDCVPSILSSRHTK----SARS---LLDAYTSYTWGCIREHLIE 721  Trypanosoma b...
XP_006655765  618 FLYWRK-EMLATWLSMVYGDACKLS--WLQSIIDAFSDGMSLLTLG--------NVGKv--TLQCYEEEIEHALRKEVVA 684 
XP_001310610  604 WLFDSR-ELYDIFLHECQKNP---R--RIVFLALSINDIG------DLFK----DNAD---LYGKCEKYFTKLLRDKFIQ 664 
XP_042934267  497 FLFWHR-SFIAAYFSAIIED--NNS--RPELFFDAINDIETILGSDDSEQ----NIK----VKESVREELYELYEKLYLK 563 
XP_002291545  481 CMYFYR-DLFPVFIENLYQTILNSSfgHTQLVLSALSDPERILKHASHLEidelSGSTk--SSIGYKNYLFGVVQEEYID 557 
EGT40989      534 GLLMGHeWLPHLYFDSIVYRKPQVD--SIEAFCSCLGGFV--------------EGAKetgQSVSMITKLKKTVDLTLIE 597 
Q4QAK3        857 PLCTEIENQLRLRTHDA--------VLGQPYrvLrpsaeAagRDLTR-YTLLQPFRFFDEWMHLEAQIEHYLSAQFYNLN 927  Leishmania major
A0DXK0        719 PLARDIEDYLRIQVHTVlie---kiTALNPFkqQ-----V--KDLKR-LLDIDYVLIFDSIVNLRTEINQILNETFYNIN 787  Paramecium te...
XP_001020690  714 PLTRQIEDFLRIQIHAMlid---kvVGKNPFkdE-----M--NNIKK-LLELEQIQFFDVIIDIKKEIQNQLNEKFYNLN 782 
Q4DZI5        690 TLCIDIENDLRLYTHSV--------VLGQPFrkVdaagrK--CDVGC-FTRLPPLRFFYEWLHIATEVEHYLDAQFYNLN 758  Trypanosoma c...
Q385H7        722 PLCVDIENDLRLCTHSV--------VLGQPFrqIgastrA--RDMAR-FTRLPPICLFSEWLHIATEVEKHLDEKFYNLN 790  Trypanosoma b...
XP_006655765  685 PLCRDIETDLRLHVHSThlk---gaVFVNPTktG-----V--RNLSW-YLRMKPLRLPSKFIDIKLLVESHLNSAFYTYS 753 
XP_001310610  665 PCLSDLEVELRFHAHQHla-----vSERNPMkkNysqfdR--------FLQTPPFKIMSRFFDMHYEASYYFTRVFYNET 731 
XP_042934267  564 KLCETVETDLRLTVHSHlq-----lDDRTPK--DpmhdaN--MRLVN-LLELPAVQLFDRLIDIKRYVEKYLESTFYNLT 633 
XP_002291545  558 PICEVVEIDLRLTVHAKn-------DQRQKAqtTstrvhT--------FINAPPLYICQKKIDVKAEVEKYLEKTFYNLC 622 
EGT40989      598 KVAAQMDMDLRILGNSNipvgdlvkADVNn---------KdlEYIGYlIKVVKKFQVGTTVVYIKESLRTLLEDKWYAME 668 
Q4QAK3        928 ALMPNDWKTYEEMRSLALRTYHLRIADSHLPSCILDQG-LDVLVITENIQQFVAYYTYNLNEQIFIQR-PSLtpSKHLHT 1005 Leishmania major
A0DXK0        788 VLNMYDQETYEQMRSLANSKFGLNLINVYLPTQTVDQGnFDVLNVLKNIQQFFTKYTYNLYQQQFVQV-TSE--SKQVYS 864  Paramecium te...
XP_001020690  783 VLNMHDMETYEQMRVLAKFYFDVNLINVYIPSQTIEQGqLDILQILRNIPTFVDTYTYNLHNQTFTQI-TTE--SKLVQT 859 
Q4DZI5        759 ALMANDWKTYEEMRNLALVRYGLRICDGYLPGSIVDQG-LDVLVITENIQVFVANYTYNMNEQLFVQR-PSTteSKHLHT 836  Trypanosoma c...
Q385H7        791 ALMANDWKTYEEIRNLALQRYGLRICDGYLPGSIVDQG-LDVLVITENIQVFVANYTYNMNEQLFVQR-PSTteSKHLHT 868  Trypanosoma b...
XP_006655765  754 VMSNYDNRMYAEMHQLGELKYGVELEDFHLSMDTVDLD-FYLKQSMENLDSFSEAYSYNIVKQMFVENdLGGqdRKNLRI 832 
XP_001310610  732 TVAPSVWETYTEMANILERLYGVSVVDCHIPGAMMQQE-IDVLEIMRNIPVFVACHNYDLNSQVFVQR-AED--SHYIAI 807 
XP_042934267  634 AVALHDSNTYMAMSLLAKQKYNLILCQSRLPFQKLDQG-PDVLFIARNIDSFVENYDYNLNEQFFIEK-DSK--SKQLTI 709 
XP_002291545  623 TLSLNDCNTYTEMRSIANERYGLCVMDPYLPDGNLEQS-VNFIDILRDLNSFVSKYNYNMIDQSFVEC-RPVlgAKFLFT 700 
EGT40989      669 ILAPNNAKIYTRMQQLAKLKYDLELLDPDLPQADADET-VAILDLLQNFSHFCSNYNFFAQGYMFIEK-ASD--SKRLHC 744 
Q4QAK3       1006 LNTRHIANSIRTHGTGVMNTAVNYVYKYLLKKMAILSHFLHDDYVRSHLLKDARAMRQRK--KE-QQPCkYPVEQAEQLI 1082 Leishmania major
A0DXK0        865 ISIQQIADSIRTHGIGILSTTVNSVYKFLQKKIQMFSQFLFDDLIQSPLVREDRFFREKK--DE-LDGQ-YPYDRAEALY 940  Paramecium te...
XP_001020690  860 IGIQQISDSIRTHGLGILNTTVNSIFKYVAKKIEILSNLLYDELILQNLIREEKWFQENK--MQ-IDGY-YPYERAKKLS 935 
Q4DZI5        837 LHIRHIANSIRTHGTGIMNTTVNYVYKCLLKKLAILSQFLYDDHVKSRLIKDAKFFIAHK--EE-LNGE-YPLSRAENFI 912  Trypanosoma c...
Q385H7        869 LHIRHIANSIRTHGTGIMNTTVNYVYKCLLKKLAILSQFLCDDHVKSRLLKNAKLLHHKK--EE-RSVE-YTLAWAEKFI 944  Trypanosoma b...
XP_006655765  833 LCVDHIASSAATCNLQRISAYLDSIFIFLNQMVVNLHALL-QSEIEIDLLRDFKQPEDIG-----MSGA-NPASQGD-MK 904 
XP_001310610  808 VGIPHIFASYRCHGIGIMNTTVDFTYRFLKTKFNTFSKFLFDDNVKSHLFNDITWFEQHK--EE-CDGQ-FPYERAEKLV 883 
XP_042934267  710 LTVEHVANSIRTHGMGIMHTTINHAYQFLKKKFYIFSQLLYDDRIRNQLIKDERYFHENA--EK-LEKM-YPVSRAQRFS 785 
XP_002291545  701 FNTKCVSASMKQHGNGIVGSAINASYNLLGKKFQLFTQFMADENVKSLLSKEFRWLNNQK--NE-CSNI-YPFSRASAFA 776 
EGT40989      745 IRMSDLKTAIRKHGVGILPTAVNSAYRIIRNKVQTFLEFLSEDTVRYQIQKYLHEMEANKstPDaKKKPhYKVSWAATVL 824 
Q4QAK3       1083 REMDRLG-V--------AH-DGV----------------SFLEKARQLISEMGNALGFMRMMRSGGLRAVAERARFVPlp 1136 Leishmania major
A0DXK0        941 KEIKKMG-T--------FD-DGT----------------NYLDKFRTLITQIGNSLAFVRLLRSAALHVNSKCLEYVPsq 994  Paramecium te...
XP_001020690  936 STLKRLG-V--------SK-EGN----------------TYLDQFRIFITQIGNALGFIRLLRSASLNYCSKSIEFLPyq 989 
Q4DZI5        913 REMHKLG-V--------AD-DGQ----------------TFLDKFRHLVSEIGNALGYMRMMRSGGLRAIADAAVFIPfi 966  Trypanosoma c...
Q385H7        945 REMHKLG-V--------AD-DGQ----------------TFLSKFRHLVSEIGNALAYMRMMRSGGLRAVADSAAFVPfv 998  Trypanosoma b...
XP_006655765  905 FSIGKLG-L--------GD-HAL----------------DLLEQVKAVVTRIGSVLGLMMVLTAGRTRYLNNISRYVR-- 956 
XP_001310610  884 TKFKRLS-Qnn-----nNT-SGL----------------SALDKFRILITEIGNALGFVRMVRSGGTRYLNNAIGFVY-- 938 
XP_042934267  786 ASIRLLG-V--------A--DDD----------------LYLDKLRILITEIGNVMGYVRLVRSGGVEASMQSLGFLP-- 836 
XP_002291545  777 QELKKFE-Le----------sGN----------------TGLDECRNVLSEIGNIIAFVRMIRAAKRKIFGDEMAFLSps 829 
EGT40989      825 KNLSKQNaLmgpiitmpGQkPGTsvtedgtevtnddlvyTYFDRFRLLITQIGNAISMVRMLCQAARENHYDRQDLFPli 904 
Q4QAK3       1137 tTAAA 1141 Leishmania major
A0DXK0        995 yNPTQ 999  Paramecium tetraurelia
XP_001020690  990 iDSED 994 
Q4DZI5        967 dNVVR 971  Trypanosoma cruzi
Q385H7        999 dADVS 1003 Trypanosoma brucei
XP_006655765  957 -KPKC 960 
XP_001310610  939 -DEDS 942 
XP_042934267  837 -NLDD 840 
XP_002291545  830 vTVEE 834 
EGT40989      905 kKHME 909 
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