6XT9


Conserved Protein Domain Family
PHTB1_N

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pfam14727: PHTB1_N (This model is not part of the current CDD release)
PTHB1 N-terminal
This entry represents the beta-propeller found at the N-terminal of PTHB1 protein (also known as Bardet-Biedl syndrome 9 protein, BBS9). This protein forms a part of the BBSome complex, which is required for ciliogenesis. PTHB1 is the major binding subunit of IFT38 C-terminal domain, which assists the BBSome in some of its roles. This beta-propeller, together with the N-terminal of ARL6, part of the platform of BBS2 and the beta-propeller of BBS7 defines a convex membrane-facing surface of the BBSome/ARL6 complex.
Statistics
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PSSM-Id: 521395
Aligned: 29 rows
Threshold Bit Score: 278.759
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XT9_I         1 MSLFKARDWWSTilgdKEE-FDQGCLCLANVDNSG--------------------NGQ-------DKIIVG--SFMGYLR 50  human
Q4CTU0         2 GSLFKLRDHWYSsy-rGEEfSHFSALTLGNADNNP--------------------DAE-------DKIIFG--SFSGTLR 51  Trypanosoma cruzi
XP_004990230   1 MSLFQAKEFWTTkacePGT-TDIGSLVVGNIDNNK--------------------DGI-------ERIVVG--SLTGDLS 50 
XP_001747349   1 MTLFQAREWWSTvvaePES-LSQACMVVDNLDNAA--------------------DRA-------DKIAVA--SYAGTLH 50 
XP_003056140   1 MSVFKTCDFWSStckgDEK-FGVGSLAVGSYD---------------------------------DKLILAtcSLFGVLR 46 
XP_002507550   1 MSVFKARELWCStc-dAREiFKGGCLAIGPPDAFN--------------------QRG-------VTIFVA--SISGILR 50 
XP_004031937   1 MSLFQTKEWWSTripdEED-FDENHLCVSNIDNNK--------------------QNS-------DRIIVG--SYKGYLR 50 
XP_001015287   1 MSLFQTKEWWNTrisgNEE-FDDKHLLVANIDNNP--------------------QHQ-------DRVVVG--SFQGFLR 50 
XP_002640221   1 MSLFRLVEWVSHti------pNTSTVLNASFFQERalikfyhiqfnwyrninfesNYGgfiilllDQLIVG--GEDGQIQ 72 
EFP02821       1 MSLFRLVEWVSHav------pKVSTVLNASFYQER------------------------------DQLVVG--GEDGQII 42 
6XT9_I        51 IFSPHPAktgD----GAQAEDLLLEVDLRDPVLQVEVGKFVSGT---EMLHLAVLHSRKLCVYSV--------------- 108 human
Q4CTU0        52 VLRPTKK---G----AAQPDDTLIEKDFGAPILQVACRPLEPVSggqPKNLIVILFPKRLVLARL--------------- 109 Trypanosoma cruzi
XP_004990230  51 IYTVAEM---E-----YRSEDLLFHTKLA-PVLQLEMGAFSSPD----ARELAILHPREIAVYTVk-------------- 103
XP_001747349  51 VYAPSGQ---GadpeH----DKRLERDLGIPILQLQVADVSGDN----LNNLVVLHPREVVVYQVq-------------- 105
XP_003056140  47 LYTPSES---D-----FADGGHALELNLKLPILKIEFGRFELGK---GNISVVVLHPRKLMVYTLwqrmp---------- 105
XP_002507550  51 VFLLHGE---G-----HAVNNLILETDLKLPVIQIEFGLFGEGG---DEASIVILHPHKLVICTLq-------------- 105
XP_004031937  51 IYAPKRR---E-----YKIEDLIFEQNFNEPIIQILCGYFGQNP---NQIQLAILFFKKILIFECe-------------- 105
XP_001015287  51 IYAPKKR---D-----FQIDDMIFEQNFNEPIIQVGCGYYSPNA---GLLLLSVLFFKKLCIFECe-------------- 105
XP_002640221  73 IMDPGFR---------ENSNHVLVTAETKYPILEMASDNFLPSM----ENILAVLSPTKLTYYa---------------- 123
EFP02821      43 ILDPGCR---------EDNNHVLVTTQTKYPIMEMASDVFLSTM----DRILAVLSPTKLTYYAVnfgkffknlldiqpy 109
6XT9_I       109 -----SGTLGnveh--------gnqCQMKLMYEHNL-----QRTACNMTYGSFGGvKGRDLICIQSMDGMLMVFEQESYA 170 human
Q4CTU0       110 -----LREREkekenentddflsalYRFTIHYEACL-----ASTSYNFTCGNFGR-ASHEMVCVQSMDGQITVVNHNTVV 178 Trypanosoma cruzi
XP_004990230 104 ----gIVGQG---------------VELSKIFGAKL-----ERTAANFVPGRFGG-AVKDVICVQSMDGALSFYNHGRLG 158
XP_001747349 106 ----sDSSGG---------------LQLEQVYRHHL-----KRTAANMVIGHFGQ-SEIAMICIQSMDGALTFFKKNREM 160
XP_003056140 106 ---------------------lskqYELHLNFEAVL-----DQGALNMVIGQFGG-SHKDVIGVQYSSGQLSVYAKGVTV 158
XP_002507550 106 ----vDEAAArd-----------nlLHLLPLKIHRFketggQISAYNMVIGRFGG-AATNRICVQSFDGKLSFYDGEVLT 169
XP_004031937 106 ----tINQQD---------------IKLKKISQCNL-----PRNSYNMCQGQFGG-QTRYQICIQSCDGMLIIINQDQIQ 160
XP_001015287 106 ----tTADQR---------------INLKKTYVCNL-----PRNAYNMCQGNFGG-SQKDQICVQSCDGLLMIIESDQVT 160
XP_002640221 124 -----SSEDTh--------------ASLDEIFSHSF-----TTSAWNMCVIPIED--SPSQILVQSIDCKLSLFQGDQCV 177
EFP02821     110 fitsaNPDDTh--------------ATLDEIFCHSF-----TTSAWNMCVIPIDD--SPSQILVQSIDCKLSLFQGDQCV 168
6XT9_I       171 FGrFLP-G-FLLPGPLAYSSRTDSFLTVSSCQQVESYKYQVLAFATDADK--RQETEQqk-----lGS-GKRLVVDWTLN 240 human
Q4CTU0       179 LQcFLPrSqFLLPGCFLYCSQRDYFLTNNSAMNLMCYSFATLVNNRIKPEvyMETNENgv-----sKTcGETISPSWTFL 253 Trypanosoma cruzi
XP_004990230 159 LVrFVP-D-FLVPGPLCYLQHADAIITSSATWAVCSYKFLVLASAGEAAAqrSGDSSQrs-----tKEgGKRVTSDWECN 231
XP_001747349 161 LVrYLP-D-FLLPGPLDYVAEDDLLVTANSSWHIKAYKFRSMAAVSEESSsqQQQASNqvsaeqstKT-GKKITEEFSFN 237
XP_003056140 159 MNcLLT-D-FTVSSPILYLHETDSFVTVSATTELKCYKYGALVTESETISq------------------ARDMPAEWSVC 218
XP_002507550 170 LVfRLE-N-VLLPGPLAYAQQDDVLLIASSSFELRCYQFTDVASRLSRDScqAGFDTTr-------G--EFVVRQHWRLC 238
XP_004031937 161 SQvQLS-D-FLLPSSLSYNQMTDQIILQNSSYEIQAYKISNIGAVSNSDN-------------------QKKLLPDWTLN 219
XP_001015287 161 AGvQLQ-E-FLLPSPISYNSATDQIVLQNSSYEIEAYKISNIGAASNSNG-------------------TKKLLPDWTLN 219
XP_002640221 178 FS-LVPlR-ALQPGPIGYCQSTQTLFVANNGF-LAAIKFSLMSSGS-----------------------QKKINYDWSFN 231
EFP02821     169 FS-LVPlR-ALQPGPIGYCQTTQTLFVANNGF-LAAIKFSLMSSGS-----------------------QKKINYDWSFN 222
6XT9_I       241 IGEQALDIcivsf----------------nqsaS------------S-VFVLGERNFFCLKDNGQIRFMKKLDWSPSCFL 291 human
Q4CTU0       254 LGEDAVGIevcrhtr------------glsaedA------------D-IVVLCHYSLFVLRLGGELRFSKRLDVESLCLT 308 Trypanosoma cruzi
XP_004990230 232 IGEEVLQLrvcg-------------------------------tktPcILALGRTSLFWIADDGSLLRSNRIESPLSCCL 280
XP_001747349 238 LGEETMAIshvk------------------------------vqdqSrLVVLGATSMYYLNMAGELLSCKRFEANCNCLA 287
XP_003056140 219 LGEPALKIvgmdhlcnykkldtngnivfnseenM------------TnILVLTECSIFGISLSGTICFQKKIDFLPMTCA 286
XP_002507550 239 IGEPVLQIlpvsnns------------adtresArgkqsfdinpcnD-VIVLAEKSIFVVSISGALKTQRRLDFVPTACR 305
XP_004031937 220 IGDQCLKIltiere-----------------------------nrihdIAILTEESLYILNQQGAIRSQKYFDYPAANII 270
XP_001015287 220 IGEQCLKLecvcrd-----------------------------hkvfdFIALTEEALFVITQTGQIRTQKRFDYPAANFY 270
XP_002640221 232 LGDTAIKMevte-------------------------------gmkPtTIILCRRHVSAFNSAGSVVWQIRLEAVGMAMC 280
EFP02821     223 LGDTAIKMevte-------------------------------glkPtTIILCRRHVSAFNGSGSVVWQIRLEAVGMAMC 271
6XT9_I       292 PYCSv----SEGT----------INTLIGNHNNMLHIYQDVTLKWATQLPH-IPVAVRVGCLH-DLKGVIVTLSDDGHLQ 355 human
Q4CTU0       309 SYLVpnt--------------naCNLLIGTVNGSVNVYSDASLDWSAKMATdAPLCLAVGEFF-KTRGMIVSLSTEGTVS 373 Trypanosoma cruzi
XP_004990230 281 PFRCvg---------------esAHVVVCGTDGIVRVMHDKKVAWAAGGAG-SPVAVATTTQC-GVKGLLTLLDENGTLS 343
XP_001747349 288 TYRVvd---------------qqINLLLGCDDGILRVLRDKTVIWAAGGVS-QPLALSTFDSP-SLPGLIAIVSAEGHLT 350
XP_003056140 287 ALPVlgsssSEKG----------RAFLVTGSTGNVQLYSGMNLLWAARHSF-SFIALSIAPIG-DTGNCMVGLGDDGYLS 354
XP_002507550 306 VLSLslggsIGH-----------FGVVVADSTGSIMVFRDSQLLWTSKLPV-KPVDLIVSYFP-DTFGHIIALGRDAVLS 372
XP_004031937 271 IQPYqqkyiKTSSesekt---kalqiIVSSFTNHLMIYEEFQLIWATRTDF-VCFGVSLGCFE-DQKGLIVGLNDQGDLQ 345
XP_001015287 271 INEIpekhaKAVLdplsqqplrvISLIITSFTHHLMIYEDFQLLWATKTDH-VCHGVGVGTFD-GQRGLLVGLNDEGWLN 348
XP_002640221 281 LYKSlqinnTQF-----------NRLIVATADDTLLIFKDNQLIWNCNSQM-SPVGLLVCSYNkSYENVITMLGSNGKIV 348
EFP02821     272 LYKSlqinnTQF-----------NRLIIATSDDTLLIFKDNQLIWNCNAQI-SPVSLLVCSYNkSYENVITMMASSGKIV 339
6XT9_I       356 CSYLGTDP 363 human
Q4CTU0       374 VNYLGTDP 381 Trypanosoma cruzi
XP_004990230 344 VVYLGTDP 351
XP_001747349 351 LYYLGTDP 358
XP_003056140 355 MSYFGTEL 362
XP_002507550 373 ISCLGTLP 380
XP_004031937 346 VFYLGTEQ 353
XP_001015287 349 VSYLGTEP 356
XP_002640221 349 IGYLGTEP 356
EFP02821     340 IGYLGTEP 347
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