Conserved Protein Domain Family
mit_SMPDase

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pfam14724: mit_SMPDase (This model is not part of the current CDD release)
Mitochondrial-associated sphingomyelin phosphodiesterase
The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyze the hydrolyzis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.
Statistics
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PSSM-Id: 521393
Aligned: 6 rows
Threshold Bit Score: 1331.78
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NXE4        40 MAFPhl-qQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVE 118 human
4_pfamImport   1 MAAP----QHSYLLASLRADCLNKPFAQRCLDLQTVIQDFPAKELHAIFPWLVESIFGSLDGVLVGWSLRTLQGRTNPTE 76 
2_pfamImport   1 MANPtl-qQPSFLLANLKADATTKPLLQRCQDLVKIIDEYPAKELHLIFPWLVESVFGSLDGVIAGWNLRFLHSRSN--E 77 
5_pfamImport   1 MAVPql-qQPSFLLANLKADCMNKSLLQQCQELVKIIDEYPAKELHFIFPWLVETVFGSLDGVLVGWNLRYLQAKAN--E 77 
XP_064424134   1 MAGPpiqqQANFLLASLKADFENKSLSQRCHDLAKVIEDYPVKELSSIFPWLIESAFGSLDGSIIGWNLRGLQSRMNPIE 80  coelacanth
XP_056677294   1 MALPhv-qPPSFLLASLKADCVNKPFTQRCHDLVKVIDDFPAKELHYIFPWLVESIFGSLDGILVGWNLRCLQGRMNPIE 79  gray short-tail...
Q9NXE4       119 YSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGG-LGLNLALNPFEYYI 197 human
4_pfamImport  77 YNLALEFLDPGGPMMELVYKLQAEEYRYDFPVSYLPAPVKASIQERILPECSLYHNKVQFPPSGGvLGLSLALNPYEYYM 156
2_pfamImport  78 YNIVMDFLNPSGPMMKLVYKLQAEEYKYEIPINYLPGPVKACIQEGVLPDCPLFHNKLQFPLSGL-LTLNIAFNPFEFFM 156
5_pfamImport  78 YNIVLEFLNPSGPMMKLVYKLQAEEYKYEFSVSYLPGPVRASIQGGVLPDCPLFHNKLQSPLSGL-LSLSLSLNPFEYYM 156
XP_064424134  81 YSTVVEFLDPSGPMMKLVYKLQAEEYKYEFPVSFLPDPVRASILEGVLPDCPLYHSKIQIPSLGG-LSLSISLNPFECFL 159 coelacanth
XP_056677294  80 YSIAMEFLDPSGPMMKLVYKLQAEDYKYDFPVSYLPEPVRACIQERVLPECPLYHNKIQFPPAGG-QGLHLalnpfeYYM 158 gray short-tail...
Q9NXE4       198 FFFALSLITQKp------------lPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSS-SPGG---TSPSP--PPR 259 human
4_pfamImport 157 FYFAISLITQK--------------VNTILGVMSNSAYFVLVDRYLKWFLPTEGNVIPPRSS-DPGG---PAPSP--APR 216
2_pfamImport 157 FNFAYCLITPKn------------yPPGQYGSSTDSAYFVLVDTYLKYFLPTEGSVPPSPFS-DSRG---SVSAP--SPR 218
5_pfamImport 157 FCFASSLITPKn------------yPVGQHVNASDSAYFVLVDNYLKYFLPTEGNVPPSPFS-DVRG---TVSPP--APR 218
XP_064424134 160 FYFAANLLTQRartflserqhpksyLVGQPVSTSDSAYFVLVDRYLKYFLPTEGNLPPPPMSlNPGG---TVSPP--VPR 234 coelacanth
XP_056677294 159 FFFALSLVTQRs------------fPMSVHVRTSDCAYFILVDryltwflptEGN-----VV-PPPSttlGCSVPspTPR 220 gray short-tail...
Q9NXE4       260 TPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLS--- 336 human
4_pfamImport 217 SPVMPFTSYGMHPTSLLKRHIAHQTSANADPASQEIWRSETMLQVFVEMWLHHYPLDIYQKIQSPHIKLETFHYHLPsiy 296
2_pfamImport 219 SSSVSFASYGIHSPSLLKHHIFHQPSVNADPAAQEIWRSETLLQMFVEIWLHHYSLEMYQKLQSPQ--LALLQYRLS--- 293
5_pfamImport 219 SPTVPFAGYGVHYSSLLKRHISHQPSVNADPAAQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPQVKLEVLQYRLG--- 295
XP_064424134 235 SPAIQFASYGIHHSSLLKRHISHQPSVNADPAAQEIWRSETVLQVFVEMWLHHYSLDLYQKLQSPHMKLEILQYRLG--- 311 coelacanth
XP_056677294 221 TPAVPFSSYGLHHTSLLKRHISHQPSVNADPASQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLS--- 297 gray short-tail...
Q9NXE4       337 VSSALY-SPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFAN-SLKPE-QA--SPSAHSHA-TSPLEEFKRAAVPR 410 human
4_pfamImport 297 SPSSSFaFPIQSSYRSYYTYQESFKPSEEQVLVIRLLVKHLHAFSNsSLRAEaPAspSPSGHSHS-PGPLEEFKRIVIPR 375
2_pfamImport 294 MSSMPCqPHAPPGSGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QLssSPSAHSHThTSPLEEFKRVVVQR 371
5_pfamImport 296 ISSLHCsTPTPPGYGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QIssSPSTHSHT--SPLEEFKRVVIPR 371
XP_064424134 312 VSNVHYgTSLQPGYGTLRAYQEPFNPSEEHVLVVRLLIKHLHAFSN-SLRPE-QI--SPLAHSHT-ASPLEEFKRVVIPR 386 coelacanth
XP_056677294 298 VSSSLHsSPAQPSYQALHAYQESFKPTEEHVLVVRLLLKHLHAFSN-SLKPE-QL--SPSTHSHT-ASPLEEFKRVVIPR 372 gray short-tail...
Q9NXE4       411 FVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPDKQAPGSDSQPRCVSEKW------APFVQENLLMYTK 482 human
4_pfamImport 376 FLQQKLYVFLHHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPERATLGAEQAPRIMSEKW------APFVQENLLMFTE 447
2_pfamImport 372 FVQQKLYLFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTGEKANPQPD-QNRTVPEKW------ESFVHENLLMYTK 442
5_pfamImport 372 FVQQKLYVFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTTDKQSPQADNQNRSVPDKW------ASFVQENLLMYTK 443
XP_064424134 387 FVQQKLYVFLQHCFGHWPLDASFRVV-------LETWLsyLQPWRYPPEKWLHAFQENQERsvpdkwAAFVQENLLLYTK 459 coelacanth
XP_056677294 373 FVQQKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPEKPFLATDPQPRSIPEKW------APFVQENLLLYTR 444 gray short-tail...
Q9NXE4       483 LFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTgsfLSPWPPAVTD 562 human
4_pfamImport 448 LFVAFLTRALRTDLVSPKNALMLFRATKVFAQPSLAPVIQKGQSLWPLRASPASCLPSQALIAPSLS---LSPTPRLLLS 524
2_pfamImport 443 LFQVFLNRAVRTDLVNAKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPEHVLHHRQPRGYLTPGQGgsyLSSRQRVVTD 522
5_pfamImport 444 LFQGFLNRAVRTDLVNAKNALMLFRVSKVFAQPNLSEMIQKGEQLFLEPEHVLHHRQHRLFMTPGHGgsfLSSRQPVITD 523
XP_064424134 460 LFQGFLNRALRTDLVSPKNALMVFRVAKVFTQPNLAEMIQKGEQLFLEPEHVLHHRQQRIFMTPSLGgsfLSLRQPAITD 539 coelacanth
XP_056677294 445 LFIGFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVMPHRQHRVFMTPNFPgnlLSSWPPTITD 524 gray short-tail...
Q9NXE4       563 ASfKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAES-------PAGHSFLSWLGFSSMDTN 635 human
4_pfamImport 525 LR-GIKSRLYGLQGQEAQYRPLFGPEVRGMVLRLVQLIVQAQQRLKSLDPSSWDAsptgplpSSSPSFLSWLRFGISDPN 603
2_pfamImport 523 MVfKVKSHVYGLEGQDCQYKQMFGTELRGAVMKLIQIIAQARQTAKRISDHSSEV-------AANKSFLSWFGLGASDLN 595
5_pfamImport 524 SVfKVKSHVYSLEGQDCQYKQMFGAEVRNSVLKLVQLIAQARQTAKSISAHTAEA-------AANQSFLSWLGFGSSDPN 596
XP_064424134 540 ASfKVKNHVYSLEGQECQYRPMFGTEVRNMVLKLAQQIAQAKQTAKSISDHSVEA-------ASSRSFLSWFKFDSPDFS 612 coelacanth
XP_056677294 525 ASfKVKSHVYSLEGQEGQYKQMFGPEVRALVLRLAQMIAQAKQTANSLSDYSNEM-------SANRSFFSWLGFRHVDVN 597 gray short-tail...
Q9NXE4       636 GSYT----ANDLDEMGQ-DSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPL 710 human
4_pfamImport 604 GSSSssaaGSDLDEAGHlDGGRRTEEYLEKALEFLCLIFRLNEAQLSRVMLTLGAAPDESGVKQRPDCAETDAGLVLTPL 683
2_pfamImport 596 NSFP----GAEPEETG--EYLKKTHEFLDRALENLCQIFKLNQGQLNQLISNLGSLEDDGNSKQLPDCVQSENGLILTDL 669
5_pfamImport 597 ASYT----GSDVDDMGL-ESIKKTDEYLDRVLDYLRQIFRLNTGQLSQIMVNYVSTQDDFGSKQLPDCIRGENGLILTDL 671
XP_064424134 613 SSYM----GNDLDELGP-SNIKKTDEYLDKALENLCHVFRLNALQLSQMAANFTTAQNDGGKKQLPDCIEGETGLILTPL 687 coelacanth
XP_056677294 598 GTFS----ANDLDELGQ-DSIKKTDEYLEKALEYLGQIFRISEAQLTQVMVNVGATPDENGKKQLPDCIMSDEGLVLTPL 672 gray short-tail...
Q9NXE4       711 GRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAG-QMAALCSRDDFLGSFCRYHLT-EPGLASR 788 human
4_pfamImport 684 GRYQIINGLRRFEISYQGDPELQPIRSYENPTLVRSLFRLSSTINERWVGaDVRGPAPGGDFLGSLARFHLL-EPAWSGG 762
2_pfamImport 670 GRRQIINGLRRFDIHYQGDPELQPIRSYENALLVRLFYRISSLINERFGR-HMNALCSRPDFLGRLSRHYLT-NLDSTTK 747
5_pfamImport 672 GRMQIINGLRRFEIDYQGDPELQPIRSYESAVLVRLLFRLSSLINERFAG-EMASLCSRRDFLGRLSRYYLT-RPPVPGK 749
XP_064424134 688 GRYQIINGLRRFDIVYQGDPELQPIRSYESAVLVRLLFRLSSAVNERFAG-DMEALCARDNFLGRLSCYYLMpPPPLVER 766 coelacanth
XP_056677294 673 GRYQIINGLRRFEIEYQGDLELQPIRSYEAAPLVRLLFRVSSALNRRFAG-QMAALCSREDFLGAFCRYHLM-DLVQAQR 750 gray short-tail...
Q9NXE4       789 HLlspvGRRQvAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFC-VGPLPCTLLLTLGYVLYASAMT 855 human
4_pfamImport 763 LG----GRQS-WEWAERPRLSLRFLASYRLLFSLALSYALTAWIC-FGPAATSGLFLLGYLLYASAMA 824
2_pfamImport 748 LKhspmSRRM-LERSQRPRLSLRPLASYRTILLLLLFYVFGSLLS-LGPISSTVLLLAGGFLYGLLMT 813
5_pfamImport 750 STrspaTRHS-PEWQTRPRLSLRGLGSYRTLCALPLLYLLASVVCsMGPLSFAFCVLLACCLYGVFMT 816
XP_064424134 767 FRhspvTRRD-LAPMQHPRVSLRFLASYRTLLSVLLLFFLASLFS-IGPLACAFLILVVVALHGIVMT 832 coelacanth
XP_056677294 751 TRlspvAPHR-AGRPHGPRISLRFLGSYRTLVSLLTIFFVASLFC-VGPLSCIVLILVTYLLYAITMT 816 gray short-tailed opossum
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