Conserved Protein Domain Family
KRAP_IP3R_bind
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pfam14722: KRAP_IP3R_bind (This model is not part of the current CDD release)
Ki-ras-induced actin-interacting protein-IP3R-interacting domain
This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function.
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Statistics
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PSSM-Id: 521391
Aligned: 15 rows
Threshold Bit Score: 188.391
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001178902  114 LSRGTSLNSCYSSTGVPQ--S-IPEWLEFWEKDPVEILLDLGFGADEPDICTQIPARFLGYSSAARGINIGVFLEAQKQR 190 
XP_023192662  145 KERGRSMNSTGSGKSSTV--SsVSELLDLYEEDPEEILLNLGFGREEPDLSSKIPPRFFNSTSSARGIDIKVYLGAQLQR 222 
XP_015199682  137 LNLGHSMASSGFSTATTKsaSsVSQVLQMCAEDAEETLYNLGFGQDEPQITAKIPPRFFSFPSQLGGINFRLFLESQLRR 216 
XP_002662570  118 YSMGQSVASSAFSTTTARtaSsLSEVLQMRAEDAEETLFQLGFGCEEPQVTARIPVRFFNFPSQLRGINFRLFLESQLSR 197 
5_pfamImport    1 ------MASSCLSSSTCTs-SsVSEILQLCSEDAEETLYELGFGRDEPQVTVRIPPRFLHFPSLSEGINFRVFLDSQLRR 73  
7_pfamImport    1 LSRGTSFNSCHSTASMPQ--S-IPEWLDFWENDPVEVLLALGFGADEPDICTQIPDRFLGCVSAARGINIHVFLEAQKQR 77  
XP_014989245  114 LSRGTSFNSCYSTASVPQ--S-IPEWLEFWEKDPVEILLDLGFGADEPDICTQIPARFLGCGSAARGINIRVFLEAQKQR 190 
XP_017199906  113 LSRGTSFSSCHSAASLPQ--S-IPEWLEFWERDPVEILLDLGFGTDEPDICAQIPARFLDCGSVARGINTHVFLEAQKQR 189 
XP_057360625  113 LSRGTSFNSCHSAASIPQ--S-IPEWLEFWEKDPVEILLDLGFGADEPDICTQIPVRFLGCDSAARGINIHVFLEAQKQR 189  Chinese pangolin
XP_056717232   45 HQKGRSMNSTG-SGKSSAtvSsVSELLELYEEDPEEVLYNLGFGRDEPDIASKIPPRFFNSSSFARGIDIKVFLNAQLQR 123  tarantolino

NP_001178902  191 IDFENPD--LYGRFRQLEILNHVTNAFSSLLNGVNTLQSQ------------------DEEKAERQVMQNPssgevkerK 250 
XP_023192662  223 LEVENPNyaLTSRFRQIEVLTTVANEFFQLYSQVSGQPVNkftskd-------qggegEKGGQQGSAGKDPstlkrtnsA 295 
XP_015199682  217 IKEEDPDlsLASRFRQVEVLTAMANAFYSLYSYVSKTPVQklappefsf-aspiekisMRFSSVRSEPRSP--------V 287 
XP_002662570  198 IRQEDPClsLASRFRQVEALTAMANAFYSLYSHVSRTPLQklappqltf-tspiversRSRNSVRSEPRSP--------V 268 
5_pfamImport   74 IREEDPSltLASRFRQVQVLTSMANAFYSLYSHVSRTPVQklatpeftfssspveridRFRSAVRSEPRSP--------V 145 
7_pfamImport   78 MDIENSN--LYGRFRQLEILDHVTSAFSSLLGDIGILQNK------------------GDEKAEGESTQRTpvngdrehR 137 
XP_014989245  191 MDIENPN--LYGRFRQLEILDRVTHAFSSLLNDVSILPNR------------------AEEKAGGESVQRTsvsatkehR 250 
XP_017199906  190 ILVENPS--LCGHFQQLGSWDHGTSTFSSLLNDVNILQNK------------------VEGESGGESAQGTsvsatkghQ 249 
XP_057360625  190 MDIENPN--LYSRFQQLEMLDHVANAFSPLLNDVNILQNK------------------AEEKDGGKNVQRTlasgakghR 249  Chinese pangolin
XP_056717232  124 MEVENPNfaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQki--------------gsMNSTASSKEAASPppltrsntA 189  tarantolino

NP_001178902  251 RKMSQLLG 258 
XP_023192662  296 RNMAKLIK 303 
XP_015199682  288 DRLKDTVS 295 
XP_002662570  269 ERLKDTIS 276 
5_pfamImport  146 ERLKDTVS 153 
7_pfamImport  138 RRMGRLLR 145 
XP_014989245  251 RRMGKLIR 258 
XP_017199906  250 RRMGKLTR 257 
XP_057360625  250 RRMGELFR 257  Chinese pangolin
XP_056717232  190 SRLMKTLS 197  tarantolino
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