2KRH


Conserved Protein Domain Family
Costars

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pfam14705: Costars (This model is not part of the current CDD release)
Costars
This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins.
Statistics
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PSSM-Id: 521380
Aligned: 59 rows
Threshold Bit Score: 76.3775
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KRH_A         9 HIYREIMELCFVIRTMARhrRD-GKIQVTFGELF--DRYVRISD--KVVGILMRARKHGLVHFEGEMLWQGKDDHVVITL 83  Norway rat
XP_004995417 500 FVADELEKLVAAIKRIGRldKPtGQYNVTFGVLF--EKTEDVFAasDVDGILLTARSVGLITYLGGLLFPGRDDLVLITL 577
6_pfamImport   1 WVDTQIRLLVEAIIKYGLrnDD-GNLQINFGVLY--DKTVNTLEaaEVGALLDSARAKGVVSFVGDNLKVFDDDLTTITL 77 
XP_003204212   2 NVEHEISLLVEEIRRLGTknAD-GQVSVKFGVLFsdEKCANLFE--ALVGTLKAAKRRKIVTYQGELLLQGVHDNVDIML 78 
A7RHL5         2 NVEHEVKLLVEELKRLGQpnSD-DKIVVKFGVLFndDRCANIFE--ALVGTLKAAKRKKIVHYDSELLLQGVHDHVDIVL 78  starlet sea ane...
XP_003387508   2 NVEHEVELLVGEIKRLGTqnAD-GQYVVTFGTLFadDKCANLFE--ALVGTLKAAKRKKIVKYDAEILLQGVHDGVEITL 78 
XP_002131888   2 NVDHEVKLLVEEIKRLGKqnAD-GQFVVTFGVLFsdDRCANIFE--ALVGTLRAAKRKKIVTYTGELLLQGVHDNVEVIL 78 
5_pfamImport   1 WMDVGIRKLLKIIFREGTidGE-GHSHISFGRLR--RKASRVFWgqALVGHLKAAKVKGAVDFAGDRLIQGASDSVDIIG 77 
XP_004992837  37 DIDHEVGLLVKCMKRIGKegDD-GKIQVTFGEIFrdEVLEQQLE--SLVGTMKAARKRGLIDFKGQILLQGAHDDVVVTL 113
XP_001742113   2 DIDHEISLLVACLKRIAEpgPD-GKLQTTFGKIFtdEILEQQLE--SLVGTMKAAKKRGIISFEGQMLLQGAHDHVVVTL 78 
2KRH_A        84 L 84  Norway rat
XP_004995417 578 V 578
6_pfamImport  78 L 78 
XP_003204212  79 L 79 
A7RHL5        79 L 79  starlet sea anemone
XP_003387508  79 L 79 
XP_002131888  79 L 79 
5_pfamImport  78 I 78 
XP_004992837 114 L 114
XP_001742113  79 L 79 
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