5D0F


Conserved Protein Domain Family
hGDE_central
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pfam14702: hGDE_central (This model is not part of the current CDD release)
Central domain of human glycogen debranching enzyme
This is a central domain of the eukaryotic variant of the glycogen debranching enzyme (GDE). The eukaryotic GDE performs two functions: 4-alpha-D-glucanotransferase, EC:2.4.1.25, and Amylo-alpha-1,6-glucosidase, EC:3.2.1.33, performed by the, respectively N- and C- terminal halves of eukaryotic GDE enzyme This central domain follows the glucanotransferase domain and precedes the glucosidase (GDE_N) domain. It is very likely that the current definition contains two or more domains, by analogy with bacterial GDEs, this domain should be involved in substrate- binding either for the N-terminal glucanotransferase and/or the the C-terminal glucosidase (or both).
Links
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Statistics
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PSSM-Id: 521378
Aligned: 110 rows
Threshold Bit Score: 188.131
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5D0F_A         727 GISKVKTLLNNMREEIASEAVDiedsEMHVHH-DGQYITFHRTNAKNGKGWYLVARTKF----HSSGDQMLPRIKLSQTK 801  Nakaseomyces...
XP_009012424   697 GIVRAKKFFNELHINLDRSGFK----EVYVDMiTDEVMSITRHNPVSHQSVILYAHTCFrandR---GGSLHNITIPGVV 769 
26_pfamImport    1 GIILGKKVINELHKKLSVEGYS----EIFVDQvNYDVVAITRHNPVNHKSIILVARTSFskpdKPWDTGYIQPLQVAGYF 76  
NP_001166124   697 GIIAGKLALNRLHQELAAKGFS----QVFVDQvDEDIVAVTRHCPSTHQSVVAVCRTAFknpkHHRYTDEVPPMCIPGKI 772 
20_pfamImport    1 GIITGKLALNKLHQELAAQGFS----QVYVDQvDADIVAVTRHCPSTHQSVVTVSRTAFknpkTHQYSNNVPPMFIPGKI 76  
XP_014302763   698 GILAARRAINTLHQELGAGGFI----QVYVDQvDEDIVAVTRHSPSSHQSVVAVCRTAFrnpkTSFYSKEVPQMCIPGKI 773 
XP_012653152   939 NLCLLRKTFIEINQTLNKH-YP----FIFYSHyDYGFLSVMRETYQKDQYYFLISRTALcendSKVN----VEIECPGII 1009
XP_015210567   699 GIIAGKLALNKLHQELASKGFI----QVYVDQvDEDIVSVTRHCPSTHQSVVAVSRTAFrnpkTSFYRNDVPPMCIPGKI 774 
XP_046800902   695 GILAGRLAMNRLHQELGTKGFN----QVYVDQvDEDIVAVTRHCPNTHQSVVAVSRTAFrdpkTSFYSKEVPEMCIPGKI 770  chicken
XP_002130821   700 GMIQGKHLLNVLHQTMAMNGFT----QIFVDQrTQDVVAVTRHNPQTHYSYILVGNTSFsd----skMKPVPPMLVEGSI 771  vase tunicate

5D0F_A         802 ATFKAAFSLERTG---------DA-PI--SDEIIEGIPT---KLR-ELTGFDIGFd------eNT-KETSILLP-QDFPQ 857  Nakaseomyces...
XP_009012424   770 DEIIIEGFLQKDR---------EE-EFvkQDDHINGLNNyklSLSeNIQATHSKIlkii----dpeNTNSNTIHfHNLVP 835 
26_pfamImport   77 NKILFEAKLe-----------gGHeEFhkNSHYLNGLKNmkaDIKqNIRLAESAMvki------esNDGSNTVHfNQFPP 139 
NP_001166124   773 EEVVLEARTVERQ---------TG-TYkkDERSINGMPEytvEIKeHIQLADSKVvrqagvtsRGrSEYVQEIVfEKLTP 842 
20_pfamImport   77 EEIVLEARTVERE---------Ar-SYkkDEKYINGMPEytvEIKeHIPMEESAVvkhagvtsKGrSEFVQEIQfQKLTP 146 
XP_014302763   774 EEVVLEARTIERN---------TK-PYkkDEKSINGMPNvtvETReHIQLHESKIvkqagittKGpNEYIQEIEfENLSP 843 
XP_012653152  1010 Q--------SIEGiysasdsidVDgNRvkNHEILTGLKT---KIYkEFNLFKYGElkfnqqtmKH------TIHfFNAPP 1072
XP_015210567   775 EEVVFEARTIERN---------AG-SYekDEKSINGMPDytvEITeHIQLKDSKIvkraevtsKGrHEFVQEIVfEHLSP 844 
XP_046800902   771 EEVVFEARTIERS----------VsPYtkDEHFINGLPNftvELReHIQIKDSKIikqagtaiKGpNEFVQEIEfENLTP 840  chicken
XP_002130821   772 MGIPLEAKPSETEqst----qdYLkGFtkDKQFINGIDNynlVVDtDIAASNSTCckil----eseDKSSQTVHfTHFPP 843  vase tunicate

5D0F_A         858 GSIVIFE----------------TQQLGID----------DS--LDHFIRSGAIK------------------------- 884  Nakaseomyces...
XP_009012424   836 GAIAVLKvlppeevr-pafmktrQILSGFGyqm----ktlSs-rKVSLTASPLEV------------------------- 884 
26_pfamImport  140 GSVVCFDvsleakh--inalnelKSLA--------------------QSKEELIY------------------------- 172 
NP_001166124   843 GSVIAFRvsldpksq-elvgvlrNHLIQFNplyk--agsvPDsnTPDILKSPLTQ------------------------- 894 
20_pfamImport  147 GSIIAFRvsldpkaq-klvgvlrFYLSQFSpkyrrgsvpdEN--PPEVLQKPLTQ------------------------- 198 
XP_014302763   844 GSVIVFRvsldphaq-vavgilrNHLTQFSphfk--agslVVdnSDPILQVPFAS------------------------- 895 
XP_012653152  1073 SLSIVIKctlhatqkqgierlnyMLHH--------------------IQDDEILA------------------------- 1107
XP_015210567   845 GSAIVFRvsldpkaq-evvsllrNHLIQFSphfk--sgslPDdkAEAILKTPFAS------------------------- 896 
XP_046800902   841 GSVIVFR----------------VSLDPKA----------QE--AVGVLRNHLIQfsphfksgslpddhsapilktlfss 892  chicken
XP_002130821   844 GSIVVLRvkvtetvn-ksisdirETIASL-----------------HNSNTHFDK------------------------- 880  vase tunicate

5D0F_A         885 ATEKLSLESINYVLYRAEQEEYDYsegRSGAYDIPDYGKPVYCGLQGWVSILRKIIFYNDLAHPLSNNLRNGHWAVDYVV 964  Nakaseomyces...
XP_009012424   885 ILQEMSLNDLNRVLFRSDAEERDDg-kGFGAYDIPRFGRLTYCGLQGLSFLLDKIRPSNDLGHPLCDNLRQGDWLMDYIA 963 
26_pfamImport  173 LLQKLSLDDLNFVLFRNNQEEFDEf--HGAVYSVPNFTDLRYCGLAGLMFYWKDIRSNNDLGHPICNNLREGLWLPDYIV 250 
NP_001166124   895 IMSKLTLADMNLLLFRCDSEEKED---GGGCYNIPGWTPLKYGGLQGLLSVMAEIRPKNDLGHPFCDNLRQGDWMIDYVS 971 
20_pfamImport  199 LMSKLTLADMNILLFRCEAEEQED---GGGCYSIPGWECLKYAGLQGLMSVLADIRPTNDLGHPLCANLREGDWLIDFVS 275 
XP_014302763   896 IASRLTLAELNQVLYRCEAEERED---GGGCYDVPRWSPLKYAGLQGLMSVLAEIRPKNDLGHPFCDNLRAGDWMIDYVS 972 
XP_012653152  1108 LYRPLKTEDINYLFFSSEQEEHERs--GYGMFNIPNKGNLLFGGLAGVFKDVNEACLYNDLGKPLFVNLREGYWYLDYII 1185
XP_015210567   897 IASKLTLADLNVLLFRCDAEEQED---GGGCYNIPSWTSLKYAGLQGLMSVMAEIRPKNDLGHPFCDNLRTGDWMIDYVS 973 
XP_046800902   893 IASKLTLADLNQVLYRCESEEQED---GGGCYNIPNWSSLKYAGLQGLMSVMADIRPKNDLGHPFCDNLRSGDWMIDYVS 969  chicken
XP_002130821   881 LVSKLNLRTLNRVLFRCNEEEMSDg-fGISAYQIPSWQKLCYCGIAGIAIPLKKISFSNDLGHPICSNLREGNWLMDYIS 959  vase tunicate

5D0F_A         965 NRL 967  Nakaseomyces glabratus CBS 138
XP_009012424   964 NRL 966 
26_pfamImport  251 NRL 253 
NP_001166124   972 NRL 974 
20_pfamImport  276 NRL 278 
XP_014302763   973 SRL 975 
XP_012653152  1186 NRL 1188
XP_015210567   974 NRL 976 
XP_046800902   970 NRL 972  chicken
XP_002130821   960 SRL 962  vase tunicate
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