5D0F


Conserved Protein Domain Family
hDGE_amylase

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pfam14701: hDGE_amylase (This model is not part of the current CDD release)
Glycogen debranching enzyme, glucanotransferase domain
This is a glucanotransferase catalytic domain of the eukaryotic variant of the glycogen debranching enzyme (GDE). The eukaryotic GDEs performs two functions: 4-alpha-D-glucanotransferase, EC:2.4.1.25, and Amylo-alpha-1,6-glucosidase, EC:3.2.1.33, performed by the, respectively N- and C- terminal halves of eukaryotic GDE enzymes. The domain is a catalytic domain responsible for the glucanotransferase function. It belongs to the alpha-amylase clan and is predicted to have a structure of a 8-stranded alpha/beta barrel (TIM barrel) where strands are interrupted by long loops and additional mini-domains. In most other amylases, the catalytic domain is followed by a beta- barrel substrate binding domain, but presence of such a domain cannot be verified in the human (and other eukaryotic) GDE enzymes.
Statistics
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PSSM-Id: 521377
Aligned: 49 rows
Threshold Bit Score: 528.33
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5D0F_A        139 KFIPLNSIAMQSVVSKWMGPtIKDWEKVFARVASKKYNMIHFTPLQHRGESNSPYSIYDQLEFDPTVf------KS---- 208  Nakaseomyces ...
P35573        120 HVLPLDCVTLQTFLAKCLGP-FDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLANQLELNPDF-------SRpnrk 191  human
Q16UP5        157 AQLPLEAIRCQTVIAKLMGP-LESWEAKLQVTKESGYNMVHFTPIQELGGSRSAYSLKNQNKVNPEF-------QNgdqp 228  yellow fever ...
XP_002050859  289 KIIPLNSIRCQTVMAKLLGP-LHTWEAKLRVAKESGYNVIHFTPIQELGGSRSGYSLRDQLSVNPNFa------AKkger 361 
2_pfamImport    1 EDLSLDCIQIQTILAKCLGP-FSTWEDKLLVARNSGYNALHFTPIQELGHSKSSYSLSDQMKLNPSF-------HDnnki 72  
XP_002427706  152 DILPLNSIAVQTVLAKSLGK-FENWKNVLKVSKESGYNMVHFTPIQELGGSNSSYCIKDQLNLNPAF-------NSdncc 223 
O62334        107 KCLPLDGIACQTYLTKLLGP-LSEWKERLEVAHQTGYNMIHLTPIHELGISNSSYSLSDHHSLIKTI-------QSqdqk 178  Caenorhabditi...
XP_004988576    6 KEVTIARLAIQTVLPTSLGP-FEEWWERILVSAKTGFNTIHFCPLQEMGGSRSPYSIRDQTKLEPSIfg---sdAGkak- 80  
XP_653608     109 KRIPINGLTIQTHIVKIMGK-IDTWEEHYRTMKECGYNCIHLTPIQKIGPSGSAYSISEHLDIENNIf-----kEEmske 182 
Q54K94        181 QVIPSESICLQTFLTKCMGS-IDQWEKHIETASKLGFNMIHYTPVQEIGESGSSYSIYDQQSISSKIfeggmnrKIined 259  Dictyostelium...
5D0F_A        209 --EKEVADMVERL-----RTEHNILSLTDIVFNHTANNSQWLLDHPEAGYNHKTSPHLISAIELDKKLLDFSEQMea--- 278  Nakaseomyces ...
P35573        192 ytWNDVGQLVEKL-----KKEWNVICITDVVYNHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWRFSCDVaegky 266  human
Q16UP5        229 veFEDVNKVIKKM-----REDWGIASICDIVLNHTANESVWIREYPECSYNCFTCPHLRPAFLLDALLARVGEDVgagll 303  yellow fever ...
XP_002050859  362 vtFDDVEKVIKKC-----RQEWGVASICDIVLNHTANESDWLLKHPDATYSCATCPYLRPAFLLDAALAQCSEDIaagkl 436 
2_pfamImport   73 itYHDIERFVNMM-----RTEWKMLSICDIVLNHTANESPFLVSHPECTYNCVNSPHLRPAYILDAALFELSIQVasgdw 147 
XP_002427706  224 pnYEDVMKLTSEM-----RKEWRILSISDVVLNHTANETPWLQVHPECTYNAITAPYLIPAAILDGHLHVLTKEIssgkh 298 
O62334        179 fgFEDVQALVGDL-----ERSWNILTVQDVVWNHAAKNATWLLEHPESAYNCLNSPHLRPAYVIDRVYHEFGKQIgegvw 253  Caenorhabditi...
XP_004988576   81 ---enLRDFLLRAgkpenKGGMGLFFIIDAVYNHTSKDTPWLLDHPEACYSLTTAPHLQPAFVLDQAIWLFSKRVgagai 157 
XP_653608     183 ekYQKIEESIYQL-----RNKYQIGSIIDIVLSHISSKSPLVIEHPEICYTIEKCPHLKIGYKFDSLIHQCIIDIikdky 257 
Q54K94        260 ekLLALSSFISDA-----EKKYGVLGMIDLVWNHTANNSAWLNQHPEAGYNTDNSPHLKSAVQLDQALQDYGKTL----- 329  Dictyostelium...
5D0F_A        279 ----lgYPVDLK-TVDDLIKVMDGIKEHVIGELKLWEFYVVDVKQTVSELREKWgnsks-----------wsddNIPSKD 342  Nakaseomyces ...
P35573        267 --kekgIPALIE-NDHHMNSIRKIIWEDIFPKLKLWEFFQVDVNKAVEQFRRLL--------------------TQENRR 323  human
Q16UP5        304 --ehvgVPKVVE-TNDHLQAIHWQIHSNYLPQIKLYELYQCDVDKYVTRFNDEA--------------------SKNGPS 360  yellow fever ...
XP_002050859  437 --ehvgVPEIID-QECHLEALKYQLHHAYLSKVNIHELYQCDVMKYVNEFMSQVr------------------tREPPKN 495 
2_pfamImport  148 --efkgIPAVIE-TEDHLNAIRHALHSHFLPLVKIHEMYIVDIHEIIAEFLNLA--------------------RNEMPQ 204 
XP_002427706  299 --eeigIPSEIY-THDHLEAVKNYLTKNLIPQLRLHEFYTADVTKLSDEFLEKA---------------------KAQIP 354 
O62334        254 --ehrgVPPVVD-NIHHVNAIEYLLRAEVLPKADLHEFYQVDLKAMVNLFEV---------------------------- 302  Caenorhabditi...
XP_004988576  158 ehkgrtVPADVK-TEEDVHFVLDAFFAHTHEALKLWEFFVVDVDAAIADMKTAF-------------------------- 210 
XP_653608     258 -----peglgIFhTENDVYRFMEYFKEKYIIPGEFWLYYVIDVNKHKEEYLK---------------------------- 304 
Q54K94        330 ------YGKEIN-NIDQLNDVINDVKTKVLPPLKLWEYYVLDIEKEVEIFKNTFfssgrvkeqipsscstfspsFLKNII 402  Dictyostelium...
5D0F_A        343 --DSTN---LAqFVRD---NAtepg--------fgslGERG----------SNKINIDKFAAILKKLHs--eDYNNg--- 391  Nakaseomyces ...
P35573        324 vtKSDPnqhLT-IIQD---PE----------------YRRF----------GCTVDMNIALTTFIPHD----KGPAaiee 369  human
Q16UP5        361 aaKEVPegdLK-LKHD---QE----------------YRRL----------GAQIDWDRAMKTYNVFRqdcfDEDSrkrk 410  yellow fever ...
XP_002050859  496 vaKESRfqeIQ-LIQD---PA----------------YRRL----------GSTIDFELALDIFNAFHgdcfDEESrfrk 545 
2_pfamImport  205 dvSDAKgkdIS-VIQD---PN----------------FRKL----------KSTINMQLALQKYNTYRadcfDEDTrlkr 254 
XP_002427706  355 tlETCSrteLK-LINN---FN-----------------GRN----------KATVNLDLALKIFNIIRndttDEETrlae 403 
O62334        303 ------------FIKQssgPTtnpldgedveieqdleCRRF----------GNTVDFERSARIFNRHRgdakSEEErvek 360  Caenorhabditi...
XP_004988576  211 ------------ARAK---PDstgqpldeslvhtrtgGGRF----------SARIRADTCAAVLKGLG------FRdqdk 259 
XP_653608     305 ------------YEKE---HKegkrgkegspeelakrLEKYvmvdgsyeknHIRINIE---------------KGFeevp 354 
Q54K94        403 snPNHEkheQIkSISK---NGiir----------apsYERY----------SLHINLDYTYKVLDTSVt--fSNNSspee 457  Dictyostelium...
5D0F_A        392 IEELATKILNDINLPFYKEYDDDINEVLEQLFNRIKYLRIDDHGPKQGPITKKLPLSEPYFTRF-------KAK------ 458  Nakaseomyces ...
P35573        370 CCNWFHKRMEELNSEKHRLINYHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKHPLVTRYFTFPfee-idfSME------ 442  human
Q16UP5        411 CAEAFRSKLQWLNEEVRKEIQAHLDYAIENCLAGARYERVQADGPQIKGISVKYPLFMKYFTQYgiqgkslKDI------ 484  yellow fever ...
XP_002050859  546 CAETLRHHLDALNDQIRAELQGHLNYAIENCLAGVRYERVQQDGPRVREISITHPVFMTYFTHTrtegkslQEI------ 619 
2_pfamImport  255 CAEDLKHKLEELNEVIINDLRNHLNAAVENTVASIRYFRVQSDGPKIKEISEKNPLVPRYFTDYgap-rslTER------ 327 
XP_002427706  404 NVNDFKKRILDLNSEIKNEIGIHLSSAIENCIANMRYFRIQEDGPKIKSVSEENPLVPRYFTGKfenydsvENEv----- 478 
O62334        361 CVRSFEEALNNKNLEAARESWEVILAGLAAVMGGITYERIADNGPKKGLVSPENPLTTDYFLHLead-lgwKSE------ 433  Caenorhabditi...
XP_004988576  260 AAKELKSFLEEYNLKLYKQLDEDMAAARTAMKHTIVWERVNPRGPQKGRITAQEPLVYLYFANVskdrqdeWSDfatcpl 339 
XP_653608     355 NLEGFIKAIDVLNVDNYRKYDEDINAAIQNCTNTIKYKCFDEAGPRIEKVSKEEHILPYYFEVI---------------- 418 
Q54K94        458 QIQKYRDILSIVNLEIYKDFDHDTEAILKNIFERIKYERVSDHGPKLGKITKSKPLLTSYFTIV-------QYR------ 524  Dictyostelium...
5D0F_A        459 ---DG-----E--EYALANNGWIWD-GNPLVDFASSQ---SKAYLRREVIVWGDCVKLRYGKGPSDSPYLWERMSKYVEM 524  Nakaseomyces ...
P35573        443 ---ESmihlpNkaCFLMAHNGWVMG-DDPLRNFAEPG---SEVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEI 515  human
Q16UP5        485 ---EAmmyggAg-KLFMAHNGWVIN-SDPLKDFARPQegtGNVYLRRELIAWGDSVKLRYGDKPEDSPYLWKHMKEYVDT 559  yellow fever ...
XP_002050859  620 ---EEdmygpAg-EFFMAHNGWVMGsSDPLLDFAEEQvnrGNVYLKRELIAWGDSVKLRFGKRPEDSPYLWQHMTEYVEK 695 
2_pfamImport  328 ---ENtmysdNg-CYLMAHNGWVMN-SNPLKNFADPD---SNVYIRRELIAWGDSVKLRYGEKPEDCPFLWRHMTAYVEQ 399 
XP_002427706  479 ---------lKngQYVMAHNGWVMN-SDPLKNFAESD---SNVYLRRELIAWGDSVKLRYGKSYQDCPFLWNHMEKYVEK 545 
O62334        434 ---EKfaydpEksKFLMAFNGWVMS-SDPMKNFALKE---SQVYLRRELVCWGDSVKLNYGNKEADSPFLWQYMKEYTQQ 506  Caenorhabditi...
XP_004988576  340 ttvDP--------KYILACNGWVWN-MDPAKDFVSKE---KRSYLRREVIIWGDSVKLRYGDSPDDNPWLWNHMCSYTRE 407 
XP_653608     419 ---DGknskgEkvHIVAAHHGWVFG-GDPFFDFVGDNk--SKVYIRREAVVWEDSLKLNYGRKYEENKFLWDYMGEYGMS 492 
Q54K94        525 ---DPnnssiR--EIPLANNGWIFN-HNPTVDFASSE---SRAYLRRDVIVWGDCVKMRYGQSPSDNQWLWNHMKTYTQN 595  Dictyostelium...
5D0F_A        525 NARIFNGFRIDNCHSTPLHVGQYFLDVARRVNPNLY 560  Nakaseomyces glabratus CBS 138
P35573        516 TATYFQGVRLDNCHSTPLHVAEYMLDAARNLQPNLY 551  human
Q16UP5        560 TAKIFDGVRLDNCHSTPLHVAEYLLDSARKVNPELY 595  yellow fever mosquito
XP_002050859  696 TARIFDGVRLDNCHSTPLHVAEYLLDAARKINPELY 731 
2_pfamImport  400 IAQIFDGIRLDNCHSTPIPVAEYMLDAARKIRPNLY 435 
XP_002427706  546 TAEIFDGIRLDNCHSTPLHVAEYLLDCARKINPDLY 581 
O62334        507 AARIFHGLRIDNAHGTPIHVAEKLLKTAREVRPDIY 542  Caenorhabditis elegans
XP_004988576  408 LASMFGGLRIDNCHSTPKHVGQAMMDAARAVNPDIL 443 
XP_653608     493 NAKIFNGFRLDNCHSVPLEALEFIIEKSREVNPELI 528 
Q54K94        596 MARIFHAIRIDNCHSTPIHLAQYLLDAAREIRPDIY 631  Dictyostelium discoideum AX4
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