7EKX


Conserved Protein Domain Family
hGDE_N

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pfam14699: hGDE_N (This model is not part of the current CDD release)
N-terminal domain from the human glycogen debranching enzyme
This domain is found on the very N-terminal of eukaryotic variants of the glycogen debranching enzyme (GDE), where it is immediately followed by the aldolase-like domain. The eukaryotic GDE performs two functions: 4-alpha-D-glucanotransferase, EC:2.4.1.25, and Amylo-alpha-1,6-glucosidase, EC:3.2.1.33, performed by the, respectively N- and C- terminal halves of eukaryotic GDE enzyme. The domain is involved in the glucosyltransferase activity, probably as a substrate-binding module (by analogy with other glucosyltransferases).
Statistics
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PSSM-Id: 521375
Aligned: 114 rows
Threshold Bit Score: 67.1542
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7EKX_A         49 VKLAIpAGSPVTRDGLIWTNCPPDfSTQFDREKFYKKIIKTSFH-----------------EDDHIDLDIYVPGTYCFYL 111  Nakaseomyces ...
2_pfamImport    1 LEFRM-GPSLFGRDVTIYTNIPAE-GSAFDRKTYRCLDWIREWSsddt---------iiddSSLSCLIQMNKAGSFHYYY 69  
XP_001986232   31 LGVHP-DVSLLGRKIILLTNYPAE-GKKFVRTEYRILDWQSKDGkpitsenh--pevhvvdTDIYSELLLKISGTFRFYF 106 
XP_002050859  180 LRVHP-DVSLLGRKILLHTNYPDE-GKKFVRTEYRVLGWQLRNGqqitsdkh--pdvhvvdTDIYSELQLNLSGTFRFYF 255 
EDW56614      138 LSVHP-DASLLGRKIVLYTNYPAE-GQKFVRTEYRVLGWQLSNGkqitsvmh--peahvvdTDIRSQVELNMSGTYHFYF 213 
XP_015034230   72 LCVHP-DSSLLGRKIALYTNYPAE-GKKFVRTEYRLLDWHLKNGkqittvmh--peahvvdTDIYAQVELQISGTFRFYF 147 
Q16UP5         53 VHVHP-GPSLLGRRVAIFCNYPAD-GADFDRNRYTQLKWFSPTGtqlesdgs--kylsikdVDYYCNVHLTRSGAYHFYI 128  yellow fever ...
XP_003435771   31 VHVHP-GASLLGRRVALYCNYPAD-DKEFCRKTYRRLEWCSAAGspletsasgseytsikdVDYYCNVHFTKSGAYHFYA 108 
XP_049538404   57 VHVHP-GASLLGRRVALYCNYPAD-GKEFDRKAYRRLDWCSAAGaplepssagseytslkdIDYYCNVHFTQSGAYHFYA 134 
1_pfamImport    1 LRLTL-SRSISSSPVVVETDFPPE-GALYVRGKLRALEWTYRTKree------------wdPDRYIDVQLSTPGPFKLTW 66  
7EKX_A        112 SFKNDKD--ELETTrKFYFVVLPILSVN 137  Nakaseomyces glabratus CBS 138
2_pfamImport   70 EHK-------GQKKgCGYINVDPDLVAG 90  
XP_001986232  107 TFADRERkaDAPPDgALYVQVEPTLNVG 134 
XP_002050859  256 RFADREAkpDAPPDgALYVQVEPTLHVG 283 
EDW56614      214 RYLERPDtgCSGADgALYVQVEPTLHVG 241 
XP_015034230  148 TYAEREVnsTSPPDgALYVQVEPTLHVG 175 
Q16UP5        129 LYe-----gEEEQQaGLYVQIEPSLTIG 151  yellow fever mosquito
XP_003435771  109 LYee---cpEAGAQaGLYVQIEPQLSVG 133 
XP_049538404  135 LYee---csEAGPKsGLYVQIEPHLTVG 159 
1_pfamImport   67 RLPSVPPs-STVLPgHGFFLVEPDLGIL 93  
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