4YRY,6S6S


Conserved Protein Domain Family
Fer4_20
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pfam14691: Fer4_20 (This model is not part of the current CDD release)
Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyzes the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds. This domain carries two Fe4-S4 clusters.
Links
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Statistics
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PSSM-Id: 521370
Aligned: 152 rows
Threshold Bit Score: 119.573
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4YRY_B          16 RRRNFEEVALGYTLEEALEEAQRCLQCPTHPCVSGCPVEIDIPGFIRKLRDGKLEESYRILKSYNNLPAVCGRVCPQEVQ 95  Thermotoga ma...
jgi:Bcell_1312  11 LRKNFEEISPGLKNQEALEESNRCLYCyDAPCIQACPTGIDIPTFIKKIASGNLKGSAKTIMSANPVGASCARVCPTEEL 90 
17_pfamImport    1 --QNFREAEPALSSRDAAHEASRCLYCYDAPCIKACPTGIDIPSFIKKISSGNMLGSAKTIMDANPVGASCSRVCPTEEL 78 
WP_012224857    15 LARNFADAHPPLGDRQAVIEAERCYACyDAPCIEACPTGIDIPGFIRKIATGNLAGSARTILESNILGGSCARVCPTEIL 94  Gluconacetoba...
Q3J1H4          20 yARNFSDVEPPLDGHEAKVAADRCYFCHDAPCVTACPTAIDIPLFIRQIATGTPEAAARTIFNQNILGGMCARVCPTEQL 99  Rhodobacter s...
WP_013068238    20 YCTAFADVAPPLTAHQAQVAAARCYFCaEAPCTTACPSDIDVPLFIRQILTGTPEAAARTILSQNIMGGMCARVCPTETL 99  Rhodobacter c...
Q1GGI2          20 IAENFADLHAPYDAHEAAVAADRCYFCyDAPCMTACPTSIDIPQFIREIQAGHAESAAKTILEQNILGGMCARVCPTETL 99  Ruegeria sp. ...
Q2YPF5          32 yaHVFDDLHPPLSPHEAIVESDRCYFCYDAPCMNACPTGIDIPLFIRQINAGNPAGAARTILAENILGGMCARVCPTETL 111 Brucella abor...
WP_013177423     9 LEARFRELKPPMTAREAKVEANRCLYCfDAPCIRACPTHIDVPTFIRKIATDNVTGAAVTILEANLMAATCARVCPVEEL 88  Truepera radi...
WP_013578666    15 TVARFADLHPSFDRQAALAEANRCLFCfDAPCMTACPTHIDVPKFIKKIASENLGGSARTILDANVMGASCSRACPVEVL 94  Granulicella ...

4YRY_B          96 CESRCVVGKmKDsE---PVAIGRLERFVADWAAEN 127 Thermotoga maritima
jgi:Bcell_1312  91 CEGACVL----NaSt-kPIVIGDLQRYATDWAIHN 120
17_pfamImport   79 CEGACVLNS-TK-S---PILIGKLQRHATDWAIKS 108
WP_012224857    95 CEQACVR----NtLdqkPLSIGALQRHATDWQMRQ 125 Gluconacetobacter diazotrophicus
Q3J1H4         100 CEEVCVRET-AEgK---PVEIARLQRHATDTLMAR 130 Rhodobacter sphaeroides 2.4.1
WP_013068238   100 CEGACVR----EaAegmPVEIGALQRFATDRLQAA 130 Rhodobacter capsulatus
Q1GGI2         100 CEEVCVR----EvAegkPVEIGRLQRYATDMLMEK 130 Ruegeria sp. TM1040
Q2YPF5         112 CEEVCVREV-AEgK---PVKIGHLQRYATDMLMAT 142 Brucella abortus 2308
WP_013177423    89 CEGACVL----GaDh-kPIEIGRLQRYAMDHLYSR 118 Truepera radiovictrix
WP_013578666    95 CEGACVM----HrYnkqPIEIARLQRFAMDAFHAP 125 Granulicella tundricola
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