7TZO


Conserved Protein Domain Family
RICTOR_M
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pfam14666: RICTOR_M (This model is not part of the current CDD release)
Rapamycin-insensitive companion of mTOR, middle domain
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Links
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Statistics
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PSSM-Id: 521348
Aligned: 93 rows
Threshold Bit Score: 75.2076
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7TZO_E        649 SSGMKP-ERSLQNNGLLTTLSQHYFLFI-GTLSCHPHGVKMLEK---CSVFQCLLNL-CSLKN-QDH---LLKLTVSSLD 718  human
O77203        675 ENKKDN-VRLLNPEKVLKTMSREYFTML-GTLSSNLLGLEILAR---NNIFDYIKPL-AELPG-RDD---LSHLIMTSLD 744  Dictyostelium...
XP_002906813  688 hiGVLK-ARMFSPDYVSRRMLREYFTLL-GLMSSSKEGLKMMEQ---SNLFQRLYVM-GTTKG-HDF---LCRLILANLD 757 
XP_002683341 2980 KPIDSE-KRLLSEERVQKYMVRDYFTII-GLMSSTIKGKELLEE---EKIFDV---L-KDLTTrRDD---ISQLIIKHLD 3047
XP_001748040  657 SDISPD-KSVFSVQAVSSTLTRDYFRLI-ACMYSTQSGQALLQEhitTRLHKCLYKE-------RRD---LGELIIDSCN 724 
XP_001470787  625 NDMKHEaTQLLKPSEFNEKMIREYISWI-GLFSQMKQGQKLLEE---AKIWDTLKNYvTIDKGkRDH---ILNLILYCLD 697 
XP_004032551  331 QNVIHQaHHLLQPQEYSTKMIREYISWI-GLFASFKYGQKLLKD---AKIWETLELY-VKYQQ-KDH---ILIHILFCLD 401 
Q6CMH7        759 QGHFVS-DMLFTENALNEKLCSGYFKIIfGVFTENSSGMSFLEK---WNVFTVINNM-FSKKSsISIk--YLMLALPELN 831  Kluyveromyces...
XP_004179832  948 EGHTKG-N-LFNSASLKTKIIGGYFKFV-GVLTQSNSGCQVLAK---WRFFTIIYKM-FELKTnMSGk--FLMLTIPELD 1018
XP_001730980  720 qlgqrasETLFSLHHLQHNIVTGYFEML-QVLSASAVGLELLTH---ARLFTPLMCL-CENED--DAsvqVVCSLLAVLD 792 

7TZO_E        719 YS--RDGLARVILSKILTAATDACRLYATKHLRVLL 752  human
O77203        745 YN--VNGASRTILQKILTSSSRVVRYLATKYLRFLL 778  Dictyostelium discoideum
XP_002906813  758 YS--VDGSSRKLLQSWMMEGSKALRLYATCLLRALL 791 
XP_002683341 3048 YTrpFSDRAREILKEAMMNGSNIIRYISTLFIRHLI 3083
XP_001748040  725 PQ--RSKAVRGLYKFALRNGSENLQIKVLAKLDVLA 758 
XP_001470787  698 YG--KENNSREFLQFCLEKGSINLQKSCLELLRLLN 731 
XP_004032551  402 YG--KQGPSRSFLYFCLQNGSENLQKASLELLRLLY 435 
Q6CMH7        832 FR--FS-RCKMFLNKALLDDREAIRILATETLGEKL 864  Kluyveromyces lactis
XP_004179832 1019 LG--HSSHCRTIIGKALVNPHENIRLKATEHIGNEL 1052
XP_001730980  793 VS--AHALPRVFLERALSDGPDRVREAATKRVGHVL 826
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