EDK45143      399 ISNDLVH--LFQTYP---KLEDEV--QIRTVLPRILFMLYHPVSEVRSSCYRILRHLIVSYESLIILLQLKILIFIIVSM 471 
XP_002114323   36 NLNNLVK--LIRSND---D-DVFLgfSLEEIVRCGRKALLSSVKEVRAATIRALRYLFKDRDAFIVFYKLHIDLFLIRAL 109 
EEC06185       45 YLNSLVK--LSPKIT---D-ETELgfSLEEVFCCLRVLLVHDASEVRAGCLRALRHLVRDASAARALVRSHVPVLVARAL 118 
1_pfamImport    1 -LNALVK--ILSSTDtceNRSEVLgfSTFEIMCCITPSLLSDSSDVRAAGLRAIRHCIKKPEDITSLVRLRLTILICRSL 77  
XP_002423154   64 YLNIFAK--LVEQAG---SGNEKFtmIKEDMLCCLKVGLVSENTLVRAGGLRVVRYFISTPDDVILLNKLQIPNLIARSI 138 
XP_011251018   62 YLNAIVK--LISE-----SESQDYgyTAEDLFCCLRVALVHEATQVRAAALRAVRYMLKKEQDVIAINRLQYPYFVARSM 134 
XP_969499      60 YLNAFVKvtLHIE-----GNFESIgfSMGDVLCCLRIALLHESTQVRSGALRAIRHVLRNEDDIAQLNKLLIPFLIARSL 134 
XP_001967270   61 LLNALASlcLGARKG---SHHSNIrfSTEELLYCLSASLVHTFTQVRAAALRTIRYALSTPNDIKTFNALQLQHLLCRSI 137 
XP_064410362   59 HLNNLIK--LLCNVG---HCEKKLglTYEEILICLRLALLNEAKEVRAAGLRALRYLVRDSSILQKVLRLKVDYLIARCI 133  coelacanth
XP_026694309   53 HLNNLVK--LFCSVP---D-DDVItiPMEVIMTCLKPTLVSEVKEVRAAGVRAYRYLINDEPSKRIFMDLKLDYLITKCL 126  vase tunicate

EDK45143      472 SndqSGQ-TLIEMEQALKLVRKFLTInkg--adlLSVGVVKALIAIVQcndpddhKGStitsnyavrvdtipEGFKNACL 548 
XP_002114323  110 D---SPYpNEIERVQVLRFLRKIIRIcp----dlFPRSLVSCLVAIGDde---ysQTR--------------DRFSYACL 165 
EEC06185      119 D---AALeSRTERLQALRLVRRLVTLap----ddLPPQLARCLVAVAAdg----aKER--------------DDLVRACL 173 
1_pfamImport   78 E---LLLdNESERLQALRIIRKSCTVcp----qqFPNAFTHSLSAIAMcs---hgPSK--------------DQLHRACV 133 
XP_002423154  139 D---LVLkNDHERIQAFRLALKILTIcp----khFSTAVTRSLVSLANsi----sENK--------------DRMINSCL 193 
XP_011251018  135 D---VNLrNEMERIQALRLVRRILVLap----khFSPALARSLISLTNgg----iEER--------------DRAFRAFL 189 
XP_969499     135 D---LLLkKDVERIEAMKLIRKILLLsp----snFHVALARSLVALANsv----vEEK--------------DRMLRICL 189 
XP_001967270  138 D---LMLkNDDERVQALKLVRKMLAIap----edISPVVVRCLVSLADsg----iEEN--------------DNLLRACL 192 
XP_064410362  134 D---IQQsNEVERTQALRLVRKMITVna----slFPSSIANSLIAVGNdg----lQER--------------DRMVRACI 188  coelacanth
XP_026694309  127 D---ISHfNEVERIQAIRLVRKIAHIkqrtnetiIPLSLASCIVSVSLgg----aEER--------------DRVYRTCL 185  vase tunicate

EDK45143      549 ETICEIALVKPELVFHGGGFKLIIDSVID--SSFEVSSTCLLIVLRLLNFQNSRKFLRNGFDLDSLIAIFSTdes----- 621 
XP_002114323  166 ATLCELAVSNAEIVALVGGINTIIRNILDc-QMHRINEAMMMTILYLFDHPMTRKYMRPQLDLEAIVAPFTDlqyrysad 244 
EEC06185      174 GTLCELALLNPKLCVETGGFRTLLHSVLDc-PQPHIAEAMLGVLFHSINDPATRHLLRLDIDLEYLVAPFTDshfryadd 252 
1_pfamImport  134 ATLCELCLLNPQAFVVGCGLKALRHVLITseLPLRMAECVLGTLLWMLNNPDTRK--LVSFDFGQLASHFTDfnpis-kp 210 
XP_002423154  194 AILCQLCVLNPELFLECNGQTALLRSTLEi-FHPRINECLVGCLLFLMNKPETRF--KANIQLEYLTSIYCDwqrnr-nk 269 
XP_011251018  190 ATLCELGVLNSNLLISCGGVGALARAAMTg-QSAAAVESIVGVLLRLLNNPDTR----SSVSLLCFAAPYCElhsss-me 263 
XP_969499     190 ATLCELGVVNTSLFIETGGVAAITRNLLEc-QTPKIAESLCGVLLLLLDKPSTRN--QAAVDLHSIAAPYCDfhyrh-gw 265 
XP_001967270  193 ATLAEFAVLNPALLIVCGGVTSITRNVLEc-HNPRIAESLCGVLLYLLEWPQTRN--ICGVRLDCLAAPYCDftyrl-gi 268 
XP_064410362  189 AIVCELALQNPEVVALRGGLSTILKNVIDc-QLSRINEALITTILHLLNHPKTRQYVRADVELEQILAPYTDfhyrhnpd 267  coelacanth
XP_026694309  186 AVLCELALLQPWLVVRCNGILALINAVLEchMYQRINECLCMSLMHIINHPCIREWHPTILDVGPTLAPYTElnyrfhad 265  vase tunicate

EDK45143      622 ldTKKSSHFSAkirkastFKLQKVSFLISGLLKDFNGLMAFSINN----FTSINNLLLNLNKRNYRVQNSILDIILDALR 697 
XP_002114323  245 ipDFELKDDHQ-------FRLTTSKLAITTIFKTWEGIICMCKADg----SGFRSLLGAFCLPNSEIRKATMDILYDVFR 313 
EEC06185      253 lpENSLSDDRE-------LRFQTSRIAMTSVLRSWPGMVYFCKPPp----SGSQSLVEVLCLPLPDARKNILALFYDIFC 321 
1_pfamImport  211 ndKNSYGE--------------TAHGTLVSLLRSWIGVLYFCDPSgdhsKSGLSSIVRALHVKNSATRIAIINLLREILG 276 
XP_002423154  270 kdQSN--------------IYTSSVLSILAALRTWTGVFYLCQPNk---VSGMKAIVDVLYLNQFEVRKAILELLYEIFG 332 
XP_011251018  264 rtK----EERE-------QRFAASKLALLSILRSYSGVLHFCRSDn---NSGLKAIADILYVEQLEVRGAVLELLYELLD 329 
XP_969499     266 kdKDKFVDERE-------LRFNCSRLALLSILRSWPGILHFCGPSn---KAGLRAVVEVLYLNQLEVRKAVLDLLYELLG 335 
XP_001967270  269 mdKNK--DARE-------LRYTSCRLALLSVLRSWTGTLEFCDPSk---PSGLKAIVDALYLNQVEVRKAILDLLYELLS 336 
XP_064410362  268 taEGHLKEDRE-------ARFLASKMAIVAAFRSWAGIINLCKPG----NSGIQSLIGVLCIPNMEIRRCLLELLYDIF- 335  coelacanth
XP_026694309  266 veDTKLKDELE-------MRFAASKMAIVSLLRTWDGLFHIVKSRd----M-IGSLVNAIRIPYNNIRRGIFAVLCDLFY 333  vase tunicate

EDK45143      698 IQVFPWL--QS------GPigdfvsrfndlkqlqlqnEKRNQKPHKQMVGNEQHYFPFKYGNKcepf-iagIVNHYQGLL 768 
XP_002114323  314 LRVPEWT--NNfsdalrNAt-----------------CTYIQDGWKLSEGWVAEEALQLLPPKttr---mnLVDNYLAVV 371 
EEC06185      322 LALPAWT--SDfeaalaSSd-----------------RAAMQESWKLYEGFVAAEGRDLLPPVtkhrqvepLLCRRLSSL 382 
1_pfamImport  277 FCPAEWV--DDvdtaieSVn-----------------PYKYREKFGLNSGYVYTEAMDLIPSLssk--rvnLVNLPQSIL 335 
XP_002423154  333 LDYEEWT--DEmdialkSId-----------------PSKYQDTWSLNDKFIAAEGKDLLPHKa-------------SLI 380 
XP_011251018  330 LPLPTWT--DEpdvalaAVd-----------------PSRSRDSWKLSEGFVAAEGKFILPSLssh--cpnITEIHSALL 388 
XP_969499     336 LPQPEWT--DElsvalsAVd-----------------PCEPQSSWRLNEGFVVAEGRSILPHLakt--tpsISDMHLSLL 394 
XP_001967270  337 LPQPTWT--DDyavalqAVd-----------------PSDFQDTWLLSNGFVSAEGRSILPTLaar--apnVVEQHLALL 395 
XP_064410362  336 ------RlpVPvvtedfIEalls------------vdpSRFQDSWRLSDGFVAAEAKTILPHRars--rpdLMDNYLALV 395  coelacanth
XP_026694309  334 FNEPTWT--EDfetalkAAa-----------------PGSFRDNWRHSEGFVVAETKSLLPVHsss--rpdLVNSHLAIL 392  vase tunicate

EDK45143      769 AYIFIINGVFDHLLKIIDdeEADEALKKKAILLLCELYTMANTLIP 814 
XP_002114323  372 LSAFSMSGLFESLVDVVT--SEDEFIAVRATILLGELLHMANTIIP 415 
EEC06185      383 LPAFLT--LLSALVEVIV--TSEDAMAIQATILLAELLYMASMFLP 424 
1_pfamImport  336 VSCLLELKLDEALVQVIL--TSDNVLSVQSTILLGEFLHLADSIVP 379 
XP_002423154  381 VYGLIECGLLSALVEVAI--TTDAILSVPAVILLG---------LP 415 
XP_011251018  389 VYVLLECGLHRALAETIV--SSDTFISVRAAVLLGALLHLAHSLLP 432 
XP_969499     395 LYCFLECGLLGAIVEVIA--TSDTFISVRATVLLGELLRLIQVLLP 438 
XP_001967270  396 LYCFLETGLLNALVEVAV--GSDQFVSVQATVLIGKILQLMHTHLP 439 
XP_064410362  396 LSAFVSNGLLEGLVEVVT--SSEDHIAVRGTILLGELLHMANTIlp 439  coelacanth
XP_026694309  393 LSSFVQSGLLQALSSVAV--SSDAQSAISSTILLGSLLHLNSRLLP 436  vase tunicate