Conserved Protein Domain Family
RasGEF_N_2

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pfam14663: RasGEF_N_2 (This model is not part of the current CDD release)
Rapamycin-insensitive companion of mTOR RasGEF_N domain
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Statistics
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PSSM-Id: 521345
Aligned: 68 rows
Threshold Bit Score: 57.2243
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_046440425  779 LAKWVIPLLLNQL-----NDKCRAVVIAAADILDEA-TDDP-ACIEVLIP-LQT--QFvqliqdqekQHL-DS--RARLL 845 
XP_001326162  577 FAANPCSLKLNRC-----LALFCEVIESQEDCLKAA-SVDQ---------------QM---------HQVlKK--ANRRI 624 
EAY10420      103 afvnliiPYFKQLvstfkQDQINQRISPILQLLYEV-VQDDpKATEYCAN-DKEvhSIlckygpigySYI---------- 170 
XP_003373603   90 YEDWGLKLMTDRL-----NDSSMEVVSVVVEALHSLmTIGVyKSSFVKLN-----------------IDLsKIddAGVLL 147 
XP_045092208  103 FSDWGIQLMLRQL-----ADESSKVVRHTLRILNRW-LPEHpSRNLRKVE-----------------WSLfGE--AGDLL 157 
EGT37340       66 FSDWGIQLMLRQL-----ADESSKVVRHTIRILSRW-LPEHpSRNLRKCE-----------------WSVfGE--AGDLL 120 
XP_022463712  979 MKKFTVEMLTRQL-----YDASPNVVATADQALYEC-IVDTdVHGEMNIS-FRT--FL---------DQMv---fIQSPV 1037
Q6FQM9        942 VQHYKMELLTRQL-----YDLSPKVVAVADRALYEY-ILTGnESEESSGStFKL--FL---------NQMv---fIRSPI 1001 [Candida] gla...
XP_004179832 1078 LINYIMEMLTRQL-----YDLNPRVVALADQALYEN-AISEtEPENLISW-LRT--SL---------SQMv---fIRSPI 1136
XP_001644281  948 LQQYMLEMLTRQL-----FDLSPKVVAVADQSLYEHvVRDEnTSTEVGTW-LRT--SL---------NQMv---fISSPI 1007
XP_046440425  846 LIKTLSIMSGFKHWQETfvetentkiS-LVQQELDQWISHLNVRYVQLVESDLADGLTQ 903 
XP_001326162  625 YSMLLSQKDSLSFV--------------NLEEEIDWWIEKGNKEYVEIYDEAISCSFND 669 
EAY10420      171 ----FSTPTALSNC--------------TVSDVVDWWMEDGNNDYFLAFDKAVEQSFLK 211 
XP_003373603  148 NTYRYSFDEAVRASDEH---------LkACIVEVNYWTYSFCEQYAAMVEEVITEIQGN 197 
XP_045092208  158 KAHIFAMESECA--NDE---------N-EVRDVTRFWMKEFNKTYLNIIDEAMKEMMFH 204 
EGT37340      121 KAHVYALEFECA--SDE---------D-EVRDVIRFWMTDFNKKYLQIIDEEMKEMMFH 167 
XP_022463712 1038 IFELLSSPYGFQLLNEI---------N-FVEQERKLWLECKNREYVTKLEDFLAATQNK 1086
Q6FQM9       1002 LFEILGRPYGFQLFNEI---------D-FVKDERDSWLEKKNIEYVDIVEEFMEQSPRN 1050 [Candida] glabrata
XP_004179832 1137 LFELLSTSYGFQLLDEV---------D-FIESERISWIKRKNEEYVNIIEDFLNGSRND 1185
XP_001644281 1008 LFELMSSKYGFQILNEI---------Q-YIEHERESWLLNKNLEYVSIVEEFIDNFQTf 1056
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