Conserved Protein Domain Family
DUF4457

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pfam14652: DUF4457 (This model is not part of the current CDD release)
Domain of unknown function (DUF4457)
This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.
Statistics
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PSSM-Id: 521336
Aligned: 18 rows
Threshold Bit Score: 420.156
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003291217 1304 FSFLSTWGDRFYMGLTS------IMIF-DNEYKQIPLTVLNITAHPKDINDVPGHSGDYRTLDKLIDGHNITTNDKHMWL 1376
XP_020435547 1789 IQFKSTWGDRYYLGLTS------IEVY-DENYQLIKLQLSNLIANPKDINDLPGHSGDYRTLDKLIDGKNVTTDDQHMWM 1861
Q553C0       2012 FLFLSTWGDRFYMGLTS------IMVF-DNEYKQIPIQASNITAQPKDINDVPGHSGDYRTLDKLIDGHNVTTNDKHMWL 2084 Dictyostelium...
XP_002902582  513 LILEANWGDPYEIGLAG------LEFL-DSSYVPLSISLDSVTISA------PIAEDRMKKLLTTHGARHLAVDPEEMWT 579 
EFJ29125      305 LNLLRSWGDCYYFGLTGiqahlfLQVL-DENGNAHSIQSEFITGKPRDLNDIPGHTGDYRTLDKLVDGCNVTTDDRHMWL 383 
5_pfamImport    1 LQLHNTWGDRNYIGLTQ------VEVLvGSRGTSIPLDAANIDATPRDLASL-GYVGDPRTLDKLIDGEATTCDDTHMWL 73  
XP_004994397 1496 LNFVETWGDPYYLGLTG------LQLI-DEHGGVIAVSMRQVEAVPRDLNDLPNVYDDDRTLDKLFDGTNITTDDEHMWL 1568
3_pfamImport    1 LRLISNWGGSH-IGLVG------LQML-GEESELIPIELHRIKLMTNELAG----GGDASDINRIINGTNITMDSNKMWQ 68  
A0DSF5       1016 IKLLRPWADQPYIGLTG------VEIY-GKEGK---IQVKNIKSDYQS-------DGDKGNIVSLINGINVTTNDMNMYI 1078 Paramecium te...
XP_001014941 1667 IFIHKSWEDKFYVGLTG------IEVY-DEYGQKIPLKESQLKARPKDLNEISGYHGDQRTLDKLIDGVNLTTNEKHMWL 1739 Tetrahymena t...
XP_003291217 1377 IPFY-PSKEH-----TLTIDLGVPMSISCIRVWNYNKSVE-------DSSRGAKKVNIYLD-GNSLCGGN---------- 1432
XP_020435547 1862 IPFR-QKHQHdqtdyHLTLDLGVETTLSCLRVWNYNKNAD-------DASRGAKEVVISLD-GKCLTS------------ 1920
Q553C0       2085 IPFS-PSKEH-----VLTIDLGNVFSISCIRIWNYNKSLD-------DASRGAKKVNIFLD-GQSLSPPPaaaassssss 2150 Dictyostelium...
XP_002902582  580 APLR-EVLALplerrAITITFSEKVSLRALKIWNYNTTLE-------GSFKGTKQVSVRID-GVHHTRVS---------- 640 
EFJ29125      384 VPYDgPEAEH-----FLEIDFKRPVTMSAFRFWNYNKSLD-------DTFRGVKWIQVLVD-NVEVSPAG---------- 440 
5_pfamImport   74 VPME-AASVP-----EVRIEFKKGQYFFGLRIWNYNKSSE-------DSFRGVKQLTVALD-GVVISPKEt--------- 130 
XP_004994397 1569 IPFT-PTGDH-----LITFFFDTPTTVSALRFYNYNKSAD-------DIYRGAKRVFVSVD-DTDVSPSG---------- 1624
3_pfamImport   69 IPFS--GNPC-----VISVNFVQAVQITGFRVWNYNASFE-------DTYSGVKEVVIELD-GQVFTTNS---------- 123 
A0DSF5       1079 LPFQ-PGRCI-----TLTFTFDIPQLITSIRIWNYNKSYD-------DTFRGAKFISLQND-QGIISNCI---------- 1134 Paramecium te...
XP_001014941 1740 VQLL-EQPQN-----YLQIDFMEEKIISGIKIWNYNKQQSyndcksvDQYRGAKIISIVADeNIQITPQQ---------- 1803 Tetrahymena t...
XP_003291217 1433 ---------------NncFIFRKAPGNSI-FD--FGQTISLYNWNKQNVSppstSSSVEQPLTSsKTNISSIVPQPRSLD 1494
XP_020435547 1921 ---------------G--YIFRKAPGESN-FD--YGQTLSFIHHDKHSQ-----ESISESYDKMmIFSKQSYIPQDYKTL 1975
Q553C0       2151 ssplnniqnnnqnnyG--FIFRKAPGNST-FD--FGQTISFFNWDKLNNNn---NNNINNNNNP-PSSCSSGTDQNKISQ 2221 Dictyostelium...
XP_002902582  641 --------------------LRKAPGNLMdFD--FGQFLYLQ-AECTRP-----SSPRLIRKKS-AMKPIAEVFQQYQTP 691 
EFJ29125      441 ---------------G--FLLRK--GMC--FNliFQSQLGFQLPGRTKN-----VKQRRIYAKL--------VLQEYLTP 486 
5_pfamImport  131 ---------------G--FLLRKAPGAAN-FD--FGQLLRF--PDIVEK-----RVTYPFSTRA---YKTPIIRQDYEAQ 180 
XP_004994397 1625 ---------------G--YLICIAPGSAA-FD--FAHTVSLHPRHRRYPPasihHKQLTPRWNA---------TNSYIVP 1675
3_pfamImport  124 ------------------FVLRRAPGHVH-YD--FAQDVHF--ESKKAALv--gSPSFKPKNNA-ITAHNHPHSDQYETP 177 
A0DSF5       1135 -------------------ALKRAPGCDT-YD--YAQTITIPSKEYVFEE----TTQVQKQLRC-----------EYEIN 1177 Paramecium te...
XP_001014941 1804 ---------------G--ILLRKAPGRDL-FD--YGQMIALPFESGWTQ-----EVIQSLQLPT---QVNSQIIQEYDTL 1855 Tetrahymena t...
XP_003291217 1495 NYPSGFTLKVLIISNHGDKNLVGLNAIEFYDQNDNLI---KSSKSNILTNd-tKYSFRvve--ngLT---HLENQGILIP 1565
XP_020435547 1976 FIPSGFVFKFVLLSSWGDKSYLGLNGMQLFDWNEDLI---DVSKSRTVLL---PPALNna----sND-----QTLSRLFD 2040
Q553C0       2222 Y-SSGFVLKLVIISNYGDRNFVGLHAIEIYDQNDTII---KPNKSSVLSNd-vKNSYKlignnlsFQeseGFLIPYFSVS 2296 Dictyostelium...
XP_002902582  692 LFPTGYIIKFVFSSTWGDTFYLGLNGVELFDRDNQLI---PLYSEIVDAQ---PRDINvlkepgaTH---DVRTLDKLYD 762 
EFJ29125      487 LFPSGHVIKFVLLSTWGDHQYLGLNGIELFDELGQSV---PVLKRILRALtyaPDNVHvlp--dmTT---HFSNPEKLFN 558 
5_pfamImport  181 LYPQGFLLKIVCWQTWGDPYYLGLNGLELYDFAGARI---DHKPAIVSAV---PYSVSeld--htNGrqqDTRTPDNLMS 252 
XP_004994397 1676 APPRVLRLSLRLIDTWGDLHYIGLNGLQLLDAFGAEI---PLTPQNIHAV---PESVNvlp--gvSG---DARTPDKLVD 1744
3_pfamImport  178 NAPTGFVYKFELLDTWGDLYYIGLNGLELYDEHGQLL---KLTENEIAAF---PSSVNild--qsLD---DVRTPDKLIN 246 
A0DSF5       1178 NLMVGHELKIQLITTFGDIHYIGLNGLEILDYKGRQV------QGNIGAE---PSSVRilq--smRG---DKRVVENLLD 1243 Paramecium te...
XP_001014941 1856 YLPRGFCFRFNIHSTWGDAHYCGLNGIEFYDSFGNPIiqkRLAEFKLGAE---PASVNilp--gcQG---DIRTIDKLVN 1927 Tetrahymena t...
XP_003291217 1566 FYS-VSFGS----LHQhlphntqLCQQfpqypsp--nknsnnrAEPPS-FSKennvIYFYFNSPIIISKIKIWNYYKVPA 1637
XP_020435547 2041 GIN-SGFDE----KHA-------WCTHalyp---------ydrSSTGL-IPIs---ICLYFDYPISLSMVKIWNYSRVPT 2095
Q553C0       2297 FGNsNNNNGmsplYHQ-------QQQQqyqlggnsvsynsrglEIPSF-SKEsn-vIYFYFDSPITVGKIKIWNYFKNIS 2367 Dictyostelium...
XP_002902582  763 GVN-NTYDD----RHM-------WLAP----------------HTPSH-PNK----LVLFFNEPMTISKIRLWNYSKTPT 809 
EFJ29125      559 GVN-NTWDT----QNM-------WLSV----------------RDYTE-GNQ----IYLYFNEPVMLSLVKIWNYSRNPT 605 
5_pfamImport  253 GLDkNTWEA----HDA-------WLAP----------------LASSL-GNQqgniVYIGFDTPVVLSMIKFWNYSKTPE 304 
XP_004994397 1745 GHY-NTNND----YHM-------WLTP----------------HTPGK-AAV----VEVLLPQPIMLGALKLWNYSKTPK 1791
3_pfamImport  247 GIN-DTLDG----RNM-------WLSP----------------VLPGQ-VNL----IYVVFDFPVTISMIKIWNYAKTTS 293 
A0DSF5       1244 GIN-ETQND----THM-------WLAPftnr--------cfdhSQDPQ-INS----LYFGSEQPFALGCIVFWNYTKTPA 1298 Paramecium te...
XP_001014941 1928 CQN-DTFDD----RNM-------WLAPfinsr------sdknvICPHLkMNT----IYLFFEKPVIISAINFWNYSKTPS 1985 Tetrahymena t...
XP_003291217 1638 QAIKDFAVYLDDLLISQGVLQKP 1660
XP_020435547 2096 RGVEEFAMYIDDLLLFKGKLSPS 2118
Q553C0       2368 QAIKEYSIYLDDLLINQGTLQKP 2390 Dictyostelium discoideum AX4
XP_002902582  810 RGVREFEVFLDDVLIYHGILKQA 832 
EFJ29125      606 FGVREIEILVDDLLVYKGYVRKA 628 
5_pfamImport  305 RGVKDLDIYLDDMHLFSGTLRKA 327 
XP_004994397 1792 RGVRHLQLWADGRIMFEGFVHPG 1814
3_pfamImport  294 RGVKTVAILVDDLLIYNGFLPP- 315 
A0DSF5       1299 RGVHEIAISLDDYIIYRGYLRQA 1321 Paramecium tetraurelia
XP_001014941 1986 RGVREIEIFLDDKLLFRGYLKKA 2008 Tetrahymena thermophila SB210
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