Conserved Protein Domain Family
DUF4455

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pfam14643: DUF4455 (This model is not part of the current CDD release)
Domain of unknown function (DUF4455)
This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.
Statistics
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PSSM-Id: 521327
Aligned: 21 rows
Threshold Bit Score: 394.736
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002505944  108 ARQRRERHERVVAAWTGERARLADVARARVATAVRELRDAIATSDASLAKGTGVYDDDAALVELTSDDAIKVWDeFVATR 187 
8_pfamImport    1 SQRRQKLHLEELMKLQKELADLSRDLEPLYLEGGETLLKKLLTSDEKVQQLFKKIESDSDLVTFTIQDLWKLWD-DVIQQ 79  
7_pfamImport    1 AEKRKEKHEKTLEEMYHDLSMISNRVEPRITSIGENLQQQLKEDDQIIEAEFSPIIEDTSLVNFSHDQLEKVWR-QIESH 79  
XP_004997848   39 GRDRHDRHISAWNKLHADLAAVREEVDERIMEHSQRARQKILESDEEARELLAQLQDDRALRTMSWQQVVMCRT-MITEH 117 
XP_002955638  119 MEGQMERHNEAWEAFVRAREEARADLEEAVAAAAASFQQRLAGDDAGIAEDMSAL-DDDRVMRLTGQELYQVWD-CVAQR 196 
XP_003057208  114 KGSREERHSLTTAAWDEERDSLCEEARERVARAVGAFRERMQRSDDAMASRTSVYDDDDALMRVEEDEVRSVWDeIANAS 193 
A0DIZ4        100 KDNRREKHLKFCDEFEKWVNRLNKNLEEAYKDIKRDITDFFSESDQQITNYYQTL-TDEALLKREIEFVESIHS-TVNAH 177  Paramecium te...
XP_004024347   30 RENRREKHLKTLNDFEKWIESLEKDVLLNYKEIKNDIDNYFIINDKQLDDYFEKL-NDDVLLKREKNIIQEIND-IVKQC 107 
2_pfamImport    1 TENKQQRHAEAVSQLHQELVVVSADFEPLFREAGEDLLHRLSESDKEMEELLQRIDSDNDLEKFTFQGLHEYWG-SVSQE 79  
XP_001021206  100 RESRRDRHIKTLNDFEKWTESLSNDVVDSYTEIKHDIEDYFIQHDKELNAYFDKF-SDQELLKREKDLLDEINQ-IVVEC 177  Tetrahymena t...
XP_002505944  188 LRDRQLWIDNLEKDVASAATETREEMASALAHTVDALTAVAHVSRGDVERFAAEATMEINADALEDRRGVAELLARLRTR 267 
8_pfamImport   80 SLQRKEWIIELDEALKKLEWKRTKMVKDILKTYTLSLEKISFLVPCDVHRYIDKQAMMINQAFLANKRAVAKLYINLIEA 159 
7_pfamImport   80 STTRRHYIKDTNEWFNQAEDERLDAIAGVFRKFSSKLIKVASLSTPDVHRLIEKESMMINQSVLANRRAYEKLHINLMES 159 
XP_004997848  118 LQGCNSIIDTLYNTLMEIEAQRVEKLRGVLRDAHRLIVSIAHVLPSEADRMVYAEAEEINRTMLDNYVAYADVKAQLLAD 197 
XP_002955638  197 IPQRARWIEECSAALEAAEERRREAVESALVSLCAGLNDAAVVSEGEVERLVEKEAMALNVAILENRRAYADLITRLQVT 276 
XP_003057208  194 IPTRSSWIDALVAEIDVAEKEVKEKLRESMTYVIDALVAVAHKTRGEIERYAADETSALNKQSIEDRRGVAELVKRLRTR 273 
A0DIZ4        178 REKRETKVNALDKRLEDLEKERFRSLELFCNRFQEGLIDVAFQLEPEITAHVDTFREEFRKVVAEKRAENQVYVQDVNRQ 257  Paramecium te...
XP_004024347  108 EVKKKNKVNNLDEKLEELEKERENNFIFFCNKLEFSLIEIAFMLEPQVKELVNIKRDEFQKSVKENRILNEEYVKNTEEQ 187 
2_pfamImport   80 SLQRRKWIEDLDETLNKYESERAVMIGEILKKYTQMLEKISYLMPPDIHRFMDKESMMINQALLANRRATGRLFVNLMEH 159 
XP_001021206  178 GIKKENKVDNLDNRLEDLEKEREKNLKFFCDKLEFTLIDIAFELEPQVKVLVDIKRKEFEQIVAQKRIENDDYIAKIKQQ 257  Tetrahymena t...
XP_002505944  268 EVELERSERGRYDAALVKWRTLRTERGVSLFAELIESERMSDNPEREAITRELAEDQvKARDSLLAHADAFK-------- 339 
8_pfamImport  160 NLKWEKSLRLKWEDRVQDWKTIQRESFVQKLKETMISERVLKPESLRKEQGLMVQEQkLLNERREQLLQTIS-------- 231 
7_pfamImport  160 DIQRELDQHRTWCERLADWKKLNAEFAVQKFTEFMKSTAIINPPGVERVMETMLKEQkELSDARQQILEQIQ-------- 231 
XP_004997848  198 RVNMEEHMDVQWEILSERWKHFKEQDLTQQCLDTILDLTAYDEQRCLR-LDQFNRDLhDLMQTRIELMKSAA-------- 268 
XP_002955638  277 EVEAERTRRAAWQDGLRRWRVLRTQHAIRTFVERIRSTEFSEPAERLAAFAALRERQsQALSALTAHWGRAG-------- 348 
XP_003057208  274 EVEMEKREFARWEEGLEKWRRVRTEHCIAEYEALIASDALQDPPTRRELMESLATHQaGAHASLVENVERLGr------- 346 
A0DIZ4        258 HQKTFKLYDETQIQKEQRWRDLKHQHYIEEFNVDIQKLEFVYPDERTKLYDNFRKTQkDIFRERKQLLEKLN-------- 329  Paramecium te...
XP_004024347  188 QLKALENFIQKRDQKILRWKQLKHDEALNIFNVEIQTMEYVNPNQRKELYQELKDRQvEIFKGKNEFLDKVN-------- 259 
2_pfamImport  160 DLQRELSHRLRWEDKLQDWKKIKMQDAIDRFKEFMSSPHIQSPEAVQRTLDTMRKAQeSLCGRRLNVLQSLRldhsssln 239 
XP_001021206  258 QKESFEAFVQRQNQVDKRWRKLKHDAAFEEFMVDIKKMEYVNPDKRIQLYEELKRQHvTIYNKRNSFIQKLD-------- 329  Tetrahymena t...
XP_002505944  340 ALLPggfdgepgsfdgvgslSRAGVELnpvgVKRWAAGLLARCDAWDGACALGLKRLETLESTLRAEADEALATVVAAVE 419 
8_pfamImport  232 GLKP----------------PTCSKKE----VHEWWSSFQHLNEEIDSMHVKHMKQFRMLYENICLECLAEIDKLREELL 291 
7_pfamImport  232 QLQP----------------PSSTKPS----VYKWNTALTKANEDLDKLHLKMVRSLHEEYEAVCQSCLSEIEKYKQNLL 291 
XP_004997848  269 HLSP----------------AFAAASEydarLQAWQADMRNIHNTYAQMHHTLRSDLQRLLQEKQDECNAAVTSCLRSLV 332 
XP_002955638  349 SVSP----------------PHLSSKK----VANWKAEVAALEEAWAKERQQHLGEMRSSEDALCARVADLVAALRAEVE 408 
XP_003057208  347 NHLP----------------PGTQY------IERWEQGFEVRHEDHGKVVDHFLEKLRADETRISAEASQTFETLRADVQ 404 
A0DIZ4        330 SIDM----------------AALTKTI----VEKWIDETKAYNELASQTIDVCCNNLLEETKKTHAHCMQRYELIKSQLL 389  Paramecium te...
XP_004024347  260 NIDM----------------NALSKSY----CEKQLEELQKYNNTAQLYFDQIFDKIMQESEENKQKCTQRVFQLQQRLN 319 
2_pfamImport  240 SITP----------------PRCTKSV----VSEWYSSLSTINEQIDTLHIDTMTKLRSYYEQIWQDCLAEIERFKKEVS 299 
XP_001021206  330 KLDI----------------LNISKAY----VEKWIEDTKNFHEQAQEILDARFEALIKESEEAKQHSIDRINQLHDRLE 389  Tetrahymena t...
XP_002505944  420 EYAGpIMDQRArEKLVRKRCVRVYDKRNADASDYIERVRSMVEPQRVEWRRKCECLMRFARRVARCRDVHRREAEAIHES 499 
8_pfamImport  292 FSQV-CTLDEV-NYLVNHKLLPLAGNLQRGIEEELDHMDKSLEKLAERTKLQSKFFNKFLQGAAHLWEVHEIGLAHQGSV 369 
7_pfamImport  292 LSKV-CDEDDM-RRIVNDHLLPLVGNQLRNFERKLEKMDQLLEEIASRTEQQLRRLFKFAQGSAHLWDVHEIGLAKQERK 369 
XP_004997848  333 DENV-CSPERA-RLLVDRECRHACVVVLRDSHKETEAFVQALDDVSATLHAEADALTEICRSLYEQWTECGQMVAQQEDA 410 
XP_002955638  409 GYQG-YPPDQL-DELVREQAGLATEERRQAALGLLAQTEAFLEQQAARWAAVSAALGGWLGKLCAMYDGHRAVTATDEAE 486 
XP_003057208  405 RYAA-YDEETQ-FAMLEERAMTPAVKRAEEAQAFIDRVETFMREQAADWKDKSEKLVDFMRRVSKYREKHFAKTEKIHED 482 
A0DIZ4        390 YARA-KSEEEL-NQLLDEQFLPQVNGLNQSARDLMKQAINYYERIDQQQTDIITNFGQFYMKIAQKNDEYKTEMQLLIHN 467  Paramecium te...
XP_004024347  320 YIEN-LPENEI-EVLLNEQINPIIIQLYENSRQQIKKSMQFQEEQDFKQNELVQNILKVFLKIGEKNDDSKKNMQKLNFE 397 
2_pfamImport  300 SYAL--SDHEV-HCICNNKLLPLVGQSQRNQEAYLEAMDKSFEELAKRVSAQSKVLFKFARGAAHLWELHSTGLQRKEQL 376 
XP_001021206  390 YVGH-LNTQDL-SSLIELECISISNKLYEDSRDLLTKAIKFVEESDFKQNELVNNIGKFFKNIGEKNDENKKNYTKMNFE 467  Tetrahymena t...
XP_002505944  500 VFARLDARRAEHERVDAAKEGAFDAACEDIAVAADEAKLEAAVDVAHQRLDDIELNYRDFNGAMGEIARSNPKSQSEAWE 579 
8_pfamImport  370 LQEKLVKCRQLHDAANNVKEATLDMAIDKLRQESCEEELKNTLAYALSVLEDIRVGYEAFHQKEVYIVESFPDTIYTEII 449 
7_pfamImport  370 LQSELEQTRQVHDTDNQEREGKLDVCLDRLRQESNDEALSVCLQQCLEMLAYIKEGYEEFHNQQMEKVAEYPSMIAEELT 449 
XP_004997848  411 VVEKIHGLRSLLRQRQAETEQALDMKIDALRQAGSKDALAGLKRAVETHLTQAKKLLEEYGDSAKGVPTTHPTKIKAQAE 490 
XP_002955638  487 VRGALKQYREAFNAADAAREAALDAAVAAVTRGSGETQLDACVAEALKRLDDIEAGYRSFHREMTSRARAYPGAVRTAND 566 
XP_003057208  483 NVAELATQRAAFEARDAECENVFKEKVERMATAATEEDLDEMFNDANGTLDDIETNYRDLRANGTATAEKYPISQSEEWA 562 
A0DIZ4        468 YEIQKAQAADKNDEVLEELTKKLKENKQKLTEALHHPRLEECLAQCYKDLDLFGEEYERFHQDNLAIANQHPNIIRNKHQ 547  Paramecium te...
XP_004024347  398 FELKKATAADENDEKLEKLNEEFEKIKFLLKQALHHPKLNELLEISFNKIDDIEKEYRDFHEKNIQIAKQQPILIQNLFL 477 
2_pfamImport  377 LQDQLDEIRHAHDQDNQGKEASLDIMMDKLRQESTEEALKNSLDKALSFLEEIKNGYFTFYKEQVDVVESYPAMVLEELQ 456 
XP_001021206  468 YELKKANIADENDEKLIQLNDEFEKIKVEMKMALHHPKLNEVLDTCFKKIDEIENEYRDFHDKNQSLAKEHPTFILNLYA 547  Tetrahymena t...
XP_002505944  580 EYQRRLCLVLRLVPNVAPRP 599 
8_pfamImport  450 SYSRSVSRYFGVKEFVKQ-- 467 
7_pfamImport  450 KYDQLVCKFFNVDRNNPVDL 469 
XP_004997848  491 AYFERVEAILGVVRLSEKAA 510 
XP_002955638  567 AYHVNLCAELGVQPQIRLAG 586 
XP_003057208  563 DYQRKLCRMLRLVPNVPPKR 582 
A0DIZ4        548 MFEKSALSIFELVDPQKEQF 567  Paramecium tetraurelia
XP_004024347  478 EYEKSILEYFELIPLSQKSQ 497 
2_pfamImport  457 LYSTAVSKFFHVKEIFKQVE 476 
XP_001021206  548 GFEKAVAQFFELHDVSKKQE 567  Tetrahymena thermophila SB210
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