Conserved Protein Domain Family
HAM1_C

?
pfam14613: HAM1_C 
HAM1-like, C-terminal domain
This is a domain found at the C-terminal end of the putative cell signalling protein HAM1 from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating during vegetative growth. Proteins with this domain often also contain an N-terminal domain pfam19343. The member, named HAM-13, is thought to associate with MAPKs and to be required for proper cell communication but it is also possible to be involved in other processes such as cell signalling or trafficking.
Statistics
?
PSSM-Id: 494403
Aligned: 47 rows
Threshold Bit Score: 111.971
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ESK85280     728 VKLDTLKFSIRDSKHDVLYKTLKPIMMGLVKKQIQKAVSDGVESGLGWIGEELVAVRSRMEEARRSTVSgeESEGE---- 803 
XP_001879374 590 kISEDVNISVKESNHAVLMTLFKPIMVMRLREALEKTMTEQLKGMVEWVDGIAFDVSQRRE-VFEDAGLggGSSLVaa-- 666 
XP_002176074 655 TTLHSLKLKVHKSRHKILLSLLKPSLMMYMKHSIQRSTELQIRKMLEQVSVESYTVHQNAKAEMKKEAKkpKKDQQsrtr 734 
XP_012191509 644 AKVDKLKFAIRDSKHDTLIKVLRPLATGIIKKAISKAAEQGIRNALQDLDTQLVELRDRIERNKEIEGK----------- 712 
CCA74851     696 AKVDSLKFSIRDSRHDLLYKTFRPLATSLIKRQVAKAIEDGLRSGFEWADRELVKVRSTVTDAKQSDGS----------- 764 
Q5KGC8       719 VNIDTLKFAIRNSKHDLLYKFIKSTATGLIKRAITAAVQNAMHTALGHLDEQLVEIRNRVDEAKQSDET----------- 787  Cryptococcus n...
4_pfamImport   1 TDVDDLSFKLRDTKHDTLYKFIKPAATSAIKKAISKAINDAIRSGLEFVDEQLVSVRNTMADAKDTDGV----------- 69  
CCD51564     641 VNMKKMKLKIKQSKHKGLLTVGKSLAMKPLTKAVCKAIELAIKQKVEEADGFLFRIKQEADRAQKEAAQ--NPENIpn-- 716 
1_pfamImport   1 VDIRKLKLKIKSSKHKALIAAGKPFLIKPLTKALAKSIEAAIKQKVEEVDAFAYKIKLEADRAKKEAAN--NPENVpn-- 76  
EPE04283     597 VDIDHLKLTLHKSSHKLLFALVKPLLLRSLRPVLKKVLEKAIRDNFNEWDATLYSIKQDADRSATVSKSv-DADAAvp-- 673 
ESK85280     804 --QIGKIKAMQEAFKRKRDDTAStsGts--------vsMSPSSssHSTFKVVSNKRDSILAKEGNPAG---WVNRSAEKE 870 
XP_001879374 667 -lWSELGRLQRE---NEDELGLRatGtgvv-----lehWHEGEgeEAKAQFAMGAEPQILSGEKRGP----LGTGSTSVK 733 
XP_002176074 735 vyFQNVISRVSELRETRKKKSHP-----------------------SPLRLVMNEKGSRLSEIELPSR---NLQRTEFYR 788 
XP_012191509 713 ----GIGDAFKDTFQKEKPEDAKknD--------------------SSFKLATSKRNSILPNLGHPDG---WIQKIDEKD 765 
CCA74851     765 -----TLDALKTAFTNKTDGSTTaaGsttaasnrspspTSTKAkrNSTFKIVPKRESMLLPDVGHERG---WIRKQGEKE 836 
Q5KGC8       788 ----TRTEALKDLYSRKKESAQEk--------------KAAADekTGTFKIVTDRDSQLNPELTHDGGk-sWAKRAFKVE 848  Cryptococcus n...
4_pfamImport  70 ----TRQEALKQLYSHKKRSAQAnkEk----------aQAKKDerNAQFAIVTSPDQELFSAHGVDKApdsITNKALYQQ 135 
CCD51564     717 -iYRQYLSAFQRQMTKGEEKAQK--A------------QASVA--DKQFNMPMTMDDSIMPHVILPGG---ISAKATEHK 776 
1_pfamImport  77 -iYRNYVSAFQRELTKGKEKAQK--A------------QQSVQ--NKEFKMVTTTDESMFPNVKLPGG---ISSKATEYK 136 
EPE04283     674 nsYNRFFDAAKTRYNANKEKKKKeaE------------AKKAKadDKKLNIAYTKDDSIFPSIVLPGG---FTTRASEYK 738 
ESK85280     871 K-LIEKGDgp--eGWRSNAFDVLVHD 893 
XP_001879374 734 EqLRATGE-----EMEVDIGEFEADT 754 
XP_002176074 789 Q-QALSGE-----GWRSSIFDSLSGD 808 
XP_012191509 766 A-AAKANPshvnkEWYSPAFSIVAAG 790 
CCA74851     837 E-LATEGE-----GWRSAAFSIVPEN 856 
Q5KGC8       849 D-AARTGK-----EWRSPAFNLIDPA 868  Cryptococcus neoformans
4_pfamImport 136 R-RAHQGP-----TWHSDAFTIVPPR 155 
CCD51564     777 N-NARQGA-----DWRSAVFDFGHAK 796 
1_pfamImport 137 N-SARQGD-----RWKSQVFGIGIAQ 156 
EPE04283     739 A-LGQQGE-----GWKSPVFTIGKAG 758 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap