Conserved Protein Domain Family
Psg1

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pfam14610: Psg1 
Ykl077w/Psg1 (Pma1 Stabilization in Golgi)
Ykl077w/Psg1 (Pma1 Stabilization in the Golgi) physically interacts with Exp1 (for ER eXport of Pma1). Psg1 can be found in the Golgi and coat protein I (COPI) vesicles but does not directly bind Pma1. Loss of Psg1 causes enhanced degradation of Pma1 in the vacuole. Psg1 is 392aa protein with a predicted signal sequence at its N-terminus and a single TMD near the C-terminus. The short cytosolic region bears 2 putative retrieval motifs KRR and KKxxKxx. It was previously shown to be cleaved by the Ca+ dependent serine protease, Kex2.
Statistics
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PSSM-Id: 494401
Aligned: 89 rows
Threshold Bit Score: 114.759
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002547108 179 DLETHLLSPLIRCTpdRYKKKgigrdKSTAPFCTPKDNSRLTMGKVYFITWYSRFFdEDVKNVRIHLNYISEKWTQKglk 258
GAD99076      48 TNPRPYAGDFPVC----TEFD-----KPYSPFCLPKDGSNVTVGSTYYVTWNPDYY-PVNATITIELRYCTPLEGDS--- 114
2_pfamImport   1 RRSSPTPGDFPIC----RDPR-----GAARPFCLPEDGANVTVGGTYYITWDADFY-PLNATITIELRYADSVEGDS--- 67 
Q0CZH9        60 HTGKTSPGEFPMC----TEEN-----TPFPPFCLPHHGADVTVDATYYVTWNADFY-PANAKITIELRYANSTQGDS--- 126 Aspergillus ter...
XP_001820255  54 QTNNASPDDFPVC----TDID-----GPFAPFCLPQDGADVIVDATYYVTWNADFY-PLNASITIEMRYSNSTVGDS--- 120
XP_001271919  61 RNITPTTVDFPIC----TDLK-----GPLAPFCLPEDGANVTVDATYYVTWNADFY-PLNTTITIEMRYANSTQGDS--- 127
Q4WPU1       105 TDISSFSGDFPIC----TDLN-----GPIAPFCLPKDGADVTADATYYVTWNADFY-PLNATITIELRYANSSQGDS--- 171 Aspergillus fum...
4_pfamImport   1 ELTGDKPKEAQAC---SSEKD-----LSIKPFCSPHDQQEVYVDDTYYVTWLTSLV-GSDSVVRVGLDYVNVSMNEGl-- 69 
XP_002844505  94 EATGERPKEAQACS---SEND-----LSVKPFCSPHDQQEVYAEDtYYATWLPSLL-DPNATVKVGMDYVNLTANEGp-- 162
XP_002584464  96 PAAQPTDSDVKACH---ADTE-----SAIYPFCEPTNGQEVYVDESYYVTWDVDAF-KINSTVQINLDYVNTTQNEGr-- 164
XP_002547108 259 krddnsteefvedddttediveaseikrrssvleqggkissNFFKSDPIDVDVGWFALDISPDWFDKE-YWRk--VLVTV 335
GAD99076     115 ------------------------------------------AFTSDRTENSYGYISLKMRQEWLQGKpRNNltlYIIEN 152
2_pfamImport  68 ------------------------------------------TFTSDRTDNSYGYTHIHMQQEWLQGKqQNPltlYIIEL 105
Q0CZH9       127 ------------------------------------------AFTSGQTVNSYGYLPVHMQSDWLQGKpQNAltlYIIEL 164 Aspergillus ter...
XP_001820255 121 ------------------------------------------AFTSEKTDNSYGYLPLHMRKEWLQEKaHNDltfYLIEL 158
XP_001271919 128 ------------------------------------------AYTSERTDNSYGYLPLHMQKEWLQGKhYNVltlYIIEL 165
Q4WPU1       172 ------------------------------------------AFTSEKTDNSYGYISLPMQKEWLQGKpYNAltlYIIEL 209 Aspergillus fum...
4_pfamImport  70 -----------------------------------------NAWLSRETPNNHSYVAIQMKPEWLKGEkRNNltfFLDEF 108
XP_002844505 163 -----------------------------------------LAFISSKTPSSYGYVTITMKKDWLKGEkRNNltmYLDEL 201
XP_002584464 165 -----------------------------------------SAYASDRIPNKIGFVTLQMDKIWLRDEsRNNltlYLLNY 203
XP_002547108 336 VPEGYEdredydvfqnsiVIEIWKGVKVGKGHLEDLkrleekyanrhiydieveeginfdeYMMMIALPTCVVLAALGMW 415
GAD99076     153 EPTSNQ------------RASYRQGPRVELMHRQVEhykppp-------------ptpynkLGLILGLPISVSAVLLVVA 207
2_pfamImport 106 DSVSDK------------RASARRGPTVVLHPKPVQhllspp-------------ptsfnkLALYIGLPVSLSVVILVVA 160
Q0CZH9       165 EPTSDQ------------RASARQGPTIMLHPKAVEhyqppp-------------plpmnkLALYVGLPLSLAVVVLVVA 219 Aspergillus ter...
XP_001820255 159 NPASGT------------RASIRKGPRITLHPKPVEhykpsp-------------pmtfnkRALFIGLPVSLSVIIVVVA 213
XP_001271919 166 DPTSGN------------RASARQGPTVVLHPRPVEhykppp-------------qipfnkKALYVGLPVSLGVVIAVVA 220
Q4WPU1       210 DPTSGS------------RASARQGPTVILHPKPVEhykpsp-------------rtpfnrTALLIGLPVSLGVVIAAVA 264 Aspergillus fum...
4_pfamImport 109 PEGK--------------GKVHHNGPTISLVNKPPVhhppppp------------tptpkpLGLLIGLPLGLGAVFLILL 162
XP_002844505 202 LPGK--------------DRIHHIGPTISLVNKPPMhyppppp------------tpapkpLGLLIGLPLGLGAVVLILL 255
XP_002584464 204 DLATED------------HSIKKAGPMISLTKKPVQhypppp-------------pskpnkLGLAVGLPISLAVVFIIAC 258
XP_002547108 416 LFVRINK--IDLS 426
GAD99076     208 GLYFGMRknRRIG 220
2_pfamImport 161 GLYFGMResRRID 173
Q0CZH9       220 GLFFGMRdsRRVA 232 Aspergillus terreus NIH2624
XP_001820255 214 GLFFGMResRRIG 226
XP_001271919 221 GLFFGMRrsRSIG 233
Q4WPU1       265 GLAFGMRksRKTG 277 Aspergillus fumigatus
4_pfamImport 163 GLCFGMKhqRRIG 175
XP_002844505 256 GLCIGMKqhRRIG 268
XP_002584464 259 GLCIGMRkhRRIG 271
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