4TVV


Conserved Protein Domain Family
PTPlike_phytase
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pfam14566: PTPlike_phytase (This model is not part of the current CDD release)
Inositol hexakisphosphate
Inositol hexakisphosphate, often called phytate, is found in abundance in seeds and acting as an inorganic phosphate reservoir. Phytases are phosphatases that hydrolyze phytate to less-phosphorylated myo-inositol derivatives and inorganic phosphate. The active-site sequence (HCXXGXGR) of the phytase identified from the gut micro-organism Selenomonas ruminantium forms a loop (P loop) at the base of a substrate binding pocket that is characteristic of protein tyrosine phosphatases (PTPs). The depth of this pocket is an important determinant of the substrate specificity of PTPs. In humans this enzyme is thought to aid bone mineralization and salvage the inositol moiety prior to apoptosis.
Links
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Statistics
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PSSM-Id: 521282
Aligned: 40 rows
Threshold Bit Score: 145.143
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4TVV_A       101 LDLRQESHG----YLNGRAITLVSAYNWINLG-KSNSQSTLDQENWLAGLRSRKIVNGVLTVPQYVAKQYSQGKsm---- 171 Legionella pneu...
Q6DIR8       549 VNLREDVIL----EANEQIFTPREPDNLEQQI-AVPAASPEQLEKLEATVANHVLTSQKWLEVYLE-QEKQMKMfkt--- 619 tropical clawed...
Q803E0       539 VNLQDELLL----EANNQIFSPREPTRVEQCI-RVCSAQPEDIQSLEASLKAQLLASQQWLEVTLE-QEKQMKMiks--- 609 zebrafish
XP_040031654 546 VNLQEELVL----EGNGQILTPREPSCPDQHI-PIPSSDPELIEKLETSLKEELLRAQKWLEVTLEQEKQMKMFks---- 616
XP_002115848 514 FNLREDLVI----QADQSTYSVREVGNLNQLL-LMNGMSANTIEKMEFKLKQELLSKSKHTIYESPGNGPKKVGlte--- 585
Q6DIR8       164 FCVREEPVLflklEDDFVPYTPRRKENLHENLhDLEKGLRA--ENLELAIRKELHDFAQLSGNSYYVYNDIEHFkde--- 238 tropical clawed...
XP_021336270 177 ICVREEPVVffrsSGDFIPYTPRRKENLHENLhDLDR--ELSTEQIELSIRKELCDFAKLSENMFSVYNDIEHFkdepqh 254
Q803E0       152 FCLREEPVVflhlQEDFLPYTPRRKENLHENLqHLQRGASS--EDLELTIRKELHDFAKLNDNMFYVYNDIEHLk----- 224 zebrafish
EDO39736      79 FNLREEPVIflslNHDYIPYSPRDPNSLKGNI-ANYGVKPEELAETEIKIREEIIKLSIEEGGKFYFYHDVDNFdn---- 153
XP_057361931  53 FCVREEPVLflraNEDFVPYTPRDKQNLCENLqGLGP--RVQAEDLELAIRKEIHDFAQLSENTYHVYHNTADLlg---- 126 Chinese pangolin

4TVV_A       172 ----vvStv---------------kNEEYYVYKKGFDYYRIFISDHRAPLDSEVDALVALIKNN-Pe----------DTW 221 Legionella pneu...
Q6DIR8       620 ----crTmq--------------eiFNQHRSAYPGLVYRRIPIPDFCAPREQDFDMLLQSMKSMlAed--------sSAA 673 tropical clawed...
Q803E0       610 ----csTvq--------------eiFNQLKSSHHALQYRRIPFPECSAPSEEGFDQLLDVMKATlAed--------sLSA 663 zebrafish
XP_040031654 617 ----clTvq--------------eiFNQHKSSQQGLVSKRIPLPDCSAPREEDFDKLLEAMKTSlAed--------sHSA 670
XP_002115848 586 ----ilTsr--------------eiFEQQIRETPQLLYYRMPIKDEQSPPEETFDYLMSIVKDL-Peiyq----dedGPA 642
Q6DIR8       239 ----phSiiihceed---ihvteevYNRPVFLLPAYRYHRLPLPMDGAPLETQFDAFVNILREN-PsllllhdanhpPPA 310 tropical clawed...
XP_021336270 255 vhilseEdihv----------teevYKRPLFSHPSHRYYRLPLPMEGAPLEETFDAFVNILRET-PnlsvtrdgsspPPA 323
Q803E0       225 -----gEpqkicicseedihiteevYRRPRFTMPAYRYYRLPLPMEGAPMEEQFDAFVKVLREN-PslslnrdasrlLPA 298 zebrafish
EDO39736     154 -----ePhsynisyee-hvcvmdeiYSRQIFLTPFLRYSRVPITATNAPEEQDFDQFINAIKDI-Pqvidv-nsaapLPA 225
XP_057361931 127 ----epHavairged--dvhvteevYKRPLFLQPTYRYHRLPLPEQGAPLEAQFDAFVSVLRET-PsllllhdahgpPPA 199 Chinese pangolin

4TVV_A       222 YHVHCRGGKGRTTTVFAMFDMLK 244 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q6DIR8       674 FVFNCHGGKGRTTTAMVIAVLTL 696 tropical clawed frog
Q803E0       664 FVFNCSNGKARTTTAMVIATLTL 686 zebrafish
XP_040031654 671 FVFNCSNGKGRTTTAMVVSVLtl 693
XP_002115848 643 FIFHCLDGKSRTTICMAIVGLIW 665
Q6DIR8       311 LLFSCQTGVGRTNLAMILGTLVL 333 tropical clawed frog
XP_021336270 324 LLFSCQVGVGRTNLGLILGALVf 346
Q803E0       299 LLFSCQVGVGRTNLGLILGTLVM 321 zebrafish
EDO39736     226 LIFNCHVGQGRTTTGMVIGCLIM 248
XP_057361931 200 LIFSCQTGVGRTNLGMVLGTLIL 222 Chinese pangolin
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