Conserved Protein Domain Family
DBB
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pfam14545: DBB (This model is not part of the current CDD release)
Dof, BCAP, and BANK (DBB) motif,
The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.
Links
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Statistics
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PSSM-Id: 521269
Aligned: 25 rows
Threshold Bit Score: 151.226
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX77290      429 KIAPKKLRSG-EERVTMILmetTENIKHMATVQVGVDLNNQLNKSVHIERLcwvNPYVITFNVPkKFLelDVVVKVQLKV 507 
EEC09131      165 RLCPRKVHQG-NNKVFVML---NQPVQQDQNIQLSLENSG--LKEVQVKWK---NPYVLQFVVPdCFLqvSKVINVHLRC 235 
XP_002432237  137 MLMPKKVNKS-QNKVLILL---NEPITKEDVMTVTMIRNNEVFEIPSVKKR---NPYTLIFRMPeEFLtvSLLVTIRVER 209 
Q9VFH9        215 TVLPKKVKLG-QNKVVALL---AEPLEKNDTLKLQVEKSGELIELRNFKCR---NPYTLQFNIPeACMeiSTMIEIRIEK 287  fruit fly
EDS41712       88 TLFPRKVKVG-QNKIIIIL---VEHLMKDDWIKIKIEMSNETIEITNVKRR---NPYTIQFNIPdACLeiSMMIGVRVEK 160 
XP_049529889  448 VLFPRKVKVG-QSKILVIL---NEPLTKEDWIKIKVEKADRTIEITNIKRR---NPYTIQFNVPeVCMeiSMMIKIRLEK 520 
2_pfamImport    1 SVHPKKVKLG-QNKIIVLL---NDPLNSEDNVSVIVDRCGDAIDISNVKRR---NPYALQFSIPeRCLevSMLVGVRISK 73  
1_pfamImport    1 SITPKKIKIG-QNKLIVLL---SEPLVSEDNVVITVDKNGHKIEVTNVTRR---NPYTLQFKMPlSCLqvSVLVNVIVEK 73  
XP_007255825  170 LILPSRVPCEnPGVVFLLL---QKPVGSKE-CEVEFSGGK-QRARVKAASW---NENTLSVAAA-DFP--AGSVGVTLYC 238 
XP_015200546  172 VVLPTRIPCEkPGELFILL---QDVAVPKD-TVVEFHGNE-QKIKVQPTLW---NEKTLCVKAL-AFP--PGTVNVTVYN 240 

EFX77290      508 GNHSWGVRDLKCQSKLGEIGVLLskcQLMGSPAEVMCQALKISPVDTEKLDQVLTRSLDKaKISLSAFGLEQ 579 
EEC09131      236 DAALLGVRQLKCESQLSQLHALL---QTVSSPYEMLCLTLGLATL--HEVDVALAQNFRR-NLPAQRFHLLG 301 
XP_002432237  210 NGVDLGTKLLKCESQLYAMAQIL---KSCDSPIEFMCQALNIVPCDKEKLDDILMSSFQR-NVPPN-FNILQ 276 
Q9VFH9        288 NNKSLGARPIKCESRLRELEQLL---RIEDSPIEFMCHALGIGPVERDALDQHLLQCFQR-NMPPN-FHLLS 354  fruit fly
EDS41712      161 NNIDLGCRPLKCESRLRELEQIL---KSQTSPVEFLCQSVGIASADRDRLDSLLLQSFQK-NVPTN-FHLLN 227 
XP_049529889  521 NSVDLGCRPLKCESQMRELEQIL---SSKDAPMELICQSLGLSTNDREKLDMLLLKAFLR-NVPPN-YNLLS 587 
2_pfamImport   74 NGFSLGVRQVKCESRLRELDQIL---RAHDNPLEFMCQTFGFSSTDREQLDNWMVHAFQK-NIPPY-FNLLS 140 
1_pfamImport   74 NGQVLGQRSVKCESRMRELDQLI---RSLDNPLNFLCQTFGLNPVDREQLDLFLVTAYVK-NVPPN-FHLLQ 140 
XP_007255825  239 GGAIKAKASLYYYSRMGEIERLL---KQAANPMNFMWQAFRVSS--KEELDQILASSLMR-KMPAGGFQGLL 304 
XP_015200546  241 RGTVTGKTQVQYYNTMGEIAVLL---KKAADPINFMWQAFQISS--TEKLDQLLSSSLRQ-RMPTGGFGVLQ 306
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