2R4I,3ROB


Conserved Protein Domain Family
DUF4440
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pfam14534: DUF4440 (This model is not part of the current CDD release)
Domain of unknown function (DUF4440)
This domain is found in uncharacterised proteins from bacteria, archaea and eukaryotes, including NTF2-Like SgcJ protein from Streptomyces carzinostaticus, which plays a role in the biosynthesis of the 9-membered enediyne antitumor antibiotic C-1027. It shows a cone-like alpha+beta barrel structure with a long N-terminal alpha- helix, a curved six-stranded antiparallel beta-sheet and two additional shorter alpha-helices. Its specific function is still unkown.
Links
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Statistics
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PSSM-Id: 521260
Aligned: 95 rows
Threshold Bit Score: 38.151
Created: 16-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2R4I_A         8 ILDCEKKLLTAIQ-NNDVESL-EVLLHD-DLLFIIPSGeT-V-T----KETDIAAYSS----GK---IA-LRAVVPSDYI 70  Cytophaga hutch...
XP_001417087 211 IVAIHEGFYRALG-EGDEEAM-AAIWSK-SKTRQSALApL-V-D----KGARLDGWDVvl-rPD---RR-PQGIIVSDLD 276
4_pfamImport   1 IRKVIADMEAAWN-RGDFRGY-MDGFLN-PGVVFVSKGrF-QdGwqgtLDHYVRDYGG----DP---AR-RGTLHFFDIQ 68 
2_pfamImport   1 IEEVVATVERTQR-ARDAEGF-LALFHP-DALWTTAHGkV-LiGlp-aIAEFTRAVLP----GA---VW-DGEVTYEVAH 67 
Q9RJZ2        30 IERVVATVERTQR-DKDAEGF-LTLFRP-DALWTTGHGkV-LlG----LDAIAEFTRAvl-pQA---VW-DGDVTYEVIH 96  Streptomyces co...
WP_013018180   5 IEAIHRTFAEYQEhQTEPEPF-LAMHRD-ETIVVNIAGrRvL-G----KEALAQAMTA----ALaspLA-QVRTTLDIED 72  Stackebrandtia ...
Q1H132        13 IKAIVSRWDQGWA-DFDAALA-SRDYAE-DADWINAFGvFkH-G----RKEIFQYLRNiyhsPQ---VT-SRRSTSSISS 80  Methylobacillus...
Q82AU3        26 IRALWAEMARGWA-AGDAALF-AASFAE-DCDFTTVRGdKpS-Grt-gIEAGHDALFH----GP---YA-GTVLDARVVA 92  Streptomyces av...
WP_015894720 430 VAALVTQFLTALG-TGDSTTA-LRTLGNvQILERGTAEpL-A-E----YR--VRHLPAd--iAF---AR-SSDVARIPRT 493 Gemmatimonas au...
Q5LLC5        46 IAAKSRRFEENFA-RGDVPALvADYYNN-DPVVIGQGVaT-F-T----GREGATQYFT----GA---VEaMKSAKLTTYT 110 Ruegeria pomeroyi

2R4I_A        71 IRII-HDTVVVSVNieIKG--EYX-----E-HTLDNTFRYLRVWKLF--DGNWKV 114 Cytophaga hutchinsonii ATCC 33406
XP_001417087 277 VTIE-KGLATLTGLetVA-----N-----G-----ATLLCTQTFERDdtDGAWIM 315
4_pfamImport  69 VQMLaPDAAQLISRyrLDR--PEA-----P-----QDGINTRLMRKV--GGRWVI 109
2_pfamImport  68 TQFLrPDVAAVKVRq-VHH--PAE-----G----DTEGAPLYVMTRQa-DGTWLL 109
Q9RJZ2        97 TQFLrPDVAAVKVRqvYHS--A-E-----G----ETEGAPLYVMTKQe-DGRWLl 138 Streptomyces coelicolor
WP_013018180  73 VRFVrEDVALVSAIknVHD--ERDekdeaD-AGFPSTGALTLLLSKE--EGQWRV 122 Stackebrandtia nassauensis
Q1H132        81 IRFIrPDIAVVTSYreTAGqkTAS-----GaEYPLRKTRDLRVLAFE--HGLWKI 128 Methylobacillus flagellatus KT
Q82AU3        93 VRFLrPDLATVEAEstITA--P-D-----G-EPL-ATTHALAVVERTa-ERRWSI 136 Streptomyces avermitilis
WP_015894720 494 VLVL-GDVAYSTVTqtITG--RYG-----K-RPKGSAGAEVIVAERT--GGGWRI 537 Gemmatimonas aurantiaca
Q5LLC5       111 IQEG-EDSAIETGGvkLTP--RED-----G-A-AQIDLTYVLVWQRH--ADGWAV 153 Ruegeria pomeroyi
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