2X3A


Conserved Protein Domain Family
Aspzincin_M35
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pfam14521: Aspzincin_M35 (This model is not part of the current CDD release)
Lysine-specific metallo-endopeptidase
This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS:M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In Grifola frondosa Peptidyl-Lys metalloendopeptidase, His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner.
Links
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Statistics
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PSSM-Id: 521252
Aligned: 44 rows
Threshold Bit Score: 98.1843
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2X3A_A       206 YLAVD-KPDGQRYRSWF---GAYSSARWDQAETNFSKIKDa---IDNKPLTFDCS------CK---QSY----FAYVY-- 263 Aeromonas salmo...
EOD48721     208 VAAEA-AENGEKLKKYF---EKNDEDTKKTVAARLRKVSAecdsENEPIAIY-CEdvw-gwCY---DHVnmwsAAYTL-- 276
EMR63559     219 ATAAS-SGSDAKVTEYF---KSATSSTRSTVSSVFSRVASecssSSSGNSRTYCSdra-saCS---GGV----IAYTV-- 284
EKG16613     205 QTAAS-SGSATKFQEYF---KTTAASTRSQVAAVFGRIASecgsTTSGSSRYYCSdvl-gaCR---SGV----LAYTQ-- 270
XP_003008306 204 ARAAA-TSDTARLQEYF---KSSSSSVSSRVAAVFSRIEEecgsTTSGISTYHCTdvy-nsCK---PGV----IAYTL-- 269
XP_003008839  90 AQNTN-SSSKSRLQKYF---KSSSARVSKQVSTVFGRIEKecssTTSGVSSYHCTdvy-naCR---TGV----IAYTL-- 155
WP_013818850 176 AKNKV-KKDRDLVSRWFadeNTDDAKLDALIEKLTAGFKKirdvCNSNQLVFSDDtvd-rsTQ---PNLwkttYALVH-- 248 Methylomonas me...
WP_005373586 187 NAGKDkGESMTLVKRWFktkGTSDTDLTSIVSELTAGFKKvqgvLNGNRLIFTDNppdrgtADetnTEA----FVWSGgw 262 Methylomicrobium
C5PE18       210 AQAAS-GGNAQKFQEYF---KTTNQQTRQNVARRFQAIAQecssANQGRTIYFCQdvy-gyC----QGA----IAYTV-- 274 Coccidioides po...
C5P507       207 RAAEA-ATNGDQLEEFF---KTTDQQTAQNIAQRFQAIAQecgsDSQGSTTYFCDdrf-ngCE---QGV----IAYTI-- 272 Coccidioides po...

2X3A_A       264 PDQ-PYkVYLCKSFWTap------vTGSD-SRAGTIVHQLSHFNVV--AGTDDL-GYGQANARNLAKTDP-VKALNNADN 331 Aeromonas salmo...
EOD48721     277 NQD-NL-ISICPGSFNmpsv-tekcHEVD--LTGILIHELTHLDRVynPATDDF-AAEWPAAAQL---NN-MQALMNGDT 346
EMR63559     285 PAS-SY-IVYCTSWFSlpaq-tstcHGDD--RPYVIVHESTHLSQV--GGTDDFsCYGYSCVRSL---SA-SQNLRHADT 353
EKG16613     271 PAS-SI-MVNCPLFFSglaptssvcHDQD--QQTTILHEVTHLSQV--AGTSDYgGYGYNFVRSL---SA-AQNLNHADT 340
XP_003008306 270 SSQ-SF-MVNCDKFFNqmpptssrcHAQD--QQTTILHEMTHLSQI--AGTSDYgGYGYNFVQSL---TA-AQNLNHADT 339
XP_003008839 156 PSQ-SF-MVNCRIFFDqmpptdkrcHAQD--QQTTILHEMTHLTEI--AGTEDYgGYGFDFVRSL---TP-AQNLNHADT 225
WP_013818850 249 DEKlHV-IYVEKVLLGr--------SGTKlEWAITIVHELSHRE----IKTKDH-FYSESGLKPNAGSFPsDKALENADN 314 Methylomonas me...
WP_005373586 263 KDSlKV-VYIEKGFFArga---nvlSGRN-NWARIIIHELTHSELDtkDYPRDN-SYGWQGINPMDPKFNgNKAITNAEN 336 Methylomicrobium
C5PE18       275 PDR-SH-VVNCPAYWSlppv-lnrgLGPD--HGYVIVHEFTHAPSVfsPGTVDH-AYGYEQCRRL---NA-QQSLNNADS 344 Coccidioides po...
C5P507       273 PAQ-SV-VVNCPAYWElppv-vnqgLDPD--HGYVVVHEFTHATSIfsPGTQDH-AYGYENCIRL---SP-EQCISNADN 342 Coccidioides po...

2X3A_A       332 HEYFAE 337 Aeromonas salmonicida subsp. achromogenes
EOD48721     347 YRLYAQ 352
EMR63559     354 YAQFAN 359
EKG16613     341 YTLYAQ 346
XP_003008306 340 YTLFAQ 345
XP_003008839 226 YTLFAQ 231
WP_013818850 315 WGFYAA 320 Methylomonas methanica
WP_005373586 337 WAYFAA 342 Methylomicrobium
C5PE18       345 YSLFAA 350 Coccidioides posadasii C735 delta SOWgp
C5P507       343 YSLYAA 348 Coccidioides posadasii C735 delta SOWgp
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