8USP


Conserved Protein Domain Family
MMS19_N
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pfam14500: MMS19_N (This model is not part of the current CDD release)
Dos2-interacting transcription regulator of RNA-Pol-II
This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
Links
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Statistics
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PSSM-Id: 521235
Aligned: 120 rows
Threshold Bit Score: 151.17
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8USP_A          49 LKDYFLSENEVERKKALTCLTTILAKTP-KdHLSkNECSVIFQFYQSKLD-DQALAKEVLEGFAALA------------- 113  Saccharomyce...
Q4DE17          43 msRYLTDEKHIIEALFVLSLATT----RrK-TLLdEEAVVVLKFFLEKLS-SLQTIETSVECITRVIeylssq------- 109  Trypanosoma ...
Q57YW3          40 MGKYLTGEEHVVNAVRVLGLATV----NrR-DRTiEEVDVMLRFFSRKLS-SMQTIAVAVESTALLVrelsse------- 106  Trypanosoma ...
10_pfamImport    4 LGPHLTSADTQSRIEACKLLSNVIQKLP-KdCLNqQELASLVEFLCNRLKdHYTLQPVVLDSLLSIS------------- 69  
9_pfamImport     4 LGPSLTSSQPQTRARGVQLLSEVLQDGR-A-ELSqKEVEVLMAFYQNRLKdHHVTTPPVLRGLLALT------------- 68  
8_pfamImport     4 LGLSLTSSQPHTRARAVQLLSQVLHDCH-G-ALTeREVEVLLAFYENRLKdHYVITPPVLHGLRALT------------- 68  
XP_005156048    45 LGVSLTSSQPQTRGRGVQLLSQVLQECY-S-GLSeREVEVLIAFYENRLKdHYVITPHVLRGLKALA------------- 109  zebrafish
XP_003961580    45 LGLSLTSSQPHTRARGVQLLSEVLQECY-G-VFTvAEVEVLISFYENRLKdHHVVIPPVLQGLRALT------------- 109  torafugu
XP_002128657    46 LGPHLTNKDTKIRIDACTLLSNVIHKLP-KdCLNqGELESLVQFLCSRLEdHYTLQPVALSLLLQLS------------- 111  vase tunicate
XP_001013640    64 MQFYFVNGREKTRQRATEFIYLFFSRYSgL-QMSqEEVESLYLFFLTKLF-DVATVKTANKVLLELLknvikhqeqmkqk 141  Tetrahymena ...

8USP_A         114 ----------PMKYVSINEIAQLLRLLL-----DNYQQGQHLASTRLWPFKILRKIFd-RFfvngsstEQV-KRIND--- 173  Saccharomyce...
Q4DE17         110 -----rpcskIVFTE-------LANGFL-----PNVRLQALPTRVRRSGFKILKYMVseA-------------TVSWltt 159  Trypanosoma ...
Q57YW3         107 -----gpctsDVFNV-------LHTEFL-----QSFSLQALPTNVRSWGYDVLRFTVtkE-------------TATWftt 156  Trypanosoma ...
10_pfamImport   70 ----------SATNLAGENATFIISSIF-----KEVHVQSCMQNERLKVFQILGTLLd-AHs------TTV-SAIGR--- 123 
9_pfamImport    69 ----------KCAALPPGSAVSMLRSLF-----QDVHVQSLMLAERACVYNMLTNLMe-TRe------AEL-KSLGA--- 122 
8_pfamImport    69 ----------KCTVLPPGSAVSMLRSLF-----QDVHVQSLMLGERACVYNMLINLMa-TRe------AEL-KGLGA--- 122 
XP_005156048   110 ----------KCSVLPPGSAVSILKSIF-----QDVHVQSLMVTERSCVYNILISLMe-SRe------EEL-KGLGA--- 163  zebrafish
XP_003961580   110 ----------KCTVLPPGSAVAMLRALF-----QDVHVQSLMLAERACVYNMLLNLMe-TRe------AEL-KGLGA--- 163  torafugu
XP_002128657   112 ----------SADNLTGENACSIITSVF-----KEVHIQTCMQHDRLKIFQILGTLLd-IHt------KDV-ITMGR--- 165  vase tunicate
XP_001013640   142 idskkagafkEFKFN-------LAKQFIekisdSKFNISQYSQDVRDSVYINLRFLQe-NFte---scVELgA------- 203  Tetrahymena ...

8USP_A         174 LFIETFLHVANGEKDPRNLLLSFALNKSIT-SSLqnvE---NFKEDLFDVLFCYFPITFKPP-KHDP-YKISNQDLKTAL 247  Saccharomyce...
Q4DE17         160 PVLCLLLEAMDEEGEPELVLHMFELYYFLS-FFVd-kNnivPLKEQYFDSISSYFPVVFSRP-PG---CSVTREELKRSL 233  Trypanosoma ...
Q57YW3         157 PFLQVVLKSMDEENEPELLMRALELHHIIA-SYAr-eDamqPLLEEYFDSISSYFPVVFSQP-PG---CKVSKEDLRRVL 230  Trypanosoma ...
10_pfamImport  124 DFLYQYIQVIDSEQDPRNLLVIFQLTKNLIdNGFp-lY---DLTEELFEVSSCYFPIDFNPAtAGKK-STITNSDLVIAL 198 
9_pfamImport   123 DFVFGFVQSMDGERDPRNLLLAFRIARNLIvQGYd-lG---KFAEELFEVTSCYFPIDFTPP-PNDP-HGITKEELVQAL 196 
8_pfamImport   123 DFVFGFVQSMDGERDPRNLLLAFQIARTIVlRGYd-lG---KFTEELFEVTSCYFPIDFSPA-PGDG-EG----GVLPKL 192 
XP_005156048   164 DFIFGFVQSVDGERDPRNLLLAFQVAKNIIyRGYd-lG---KFVEELFEVTSCYFPIDFSPP-PNDP-HGITQEELILSL 237  zebrafish
XP_003961580   164 DFVFGFVQSMDGERDPRNLLLAFQVAKNIIhRGYe-lG---SFTEEMFEVTSCYFPIDFAPP-PNDP-HGITREELVVTL 237  torafugu
XP_002128657   166 DFLYQYIQVIDGEQDPRNLLTIFQLTKNLIeSSFp-lF---DLVEELFDVSSCYFPIDFNPAaAGKK-STITNLDLVSSL 240  vase tunicate
XP_001013640   204 TYVKVIIESTEDEKDPRCIIKSFKLIRFVL-ENFs-lSmlkPFLEDIFDNLECYYPIDFQPDpEQDKkYQISPKDLSEAL 281  Tetrahymena ...

8USP_A         248 RSAITATPLFAE----DAYSNLLDKLTASSPVVKNDTLLTLLECVRKF---GGSSILENWTLLWNALKFEIMQ 313  Saccharomyces cerev...
Q4DE17         234 TRCMTC-PLYLD----PCVSFTLSRLSSPSSFVKQESIAVLLELFSPEsahDMNDLSPHILPVVSHVRNEVIk 301  Trypanosoma cruzi
Q57YW3         231 SACMTH-PLYLN----ICVPFLLSRMASPSSVVKQESTNALLNIFSLDsshTTESLCPHVVSVTNHIRNEVvr 298  Trypanosoma brucei
10_pfamImport  199 RGVLASTPDFAP----YCIPLLMEKLDSDVESAKIDSIETLTACLICY---GKNELETYLSTIWTSLKREINQ 264 
9_pfamImport   197 RAVLTGTPKFAE----FLFPLLIEKLDSEVQSAKLDALQTLNACLSRF---EHKDTAEFLQGLWSSLRREVFQ 262 
8_pfamImport   193 RGVPPGTPRFWRlplyFSLPLTIERLVSDVHR---DTLLSVVAGVSKY---EHKDVAEFLEGLWASLRREVFQ 259 
XP_005156048   238 RAVLTGTPRFAE----FLLPLIIEKMDSDVQSAKVDSMHTLAACGQTY---SHKELAEFLPGLWSSIRREVFQ 303  zebrafish
XP_003961580   238 RDVLVGTPKFAE----FLLPLIIEKLDSDVQSAKLDSLQTLTACVTGY---EHKDLAEFLGGLWASLRREVFQ 303  torafugu
XP_002128657   241 RGVLASTKQFAQ----YCIPLMLEKLESDVESAKIDSLETLTACLGCY---GKQELEKYLSSLWSDVKREINQ 306  vase tunicate
XP_001013640   282 DLCLINKHILQK-----TLDIINEKINSSYIDAKLAAMQTYQLVFKNY----------LPGQLLSSQRKQILN 339  Tetrahymena thermop...
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