Conserved Protein Domain Family
HeLo

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pfam14479: HeLo (This model is not part of the current CDD release)
Prion-inhibition and propagation
This N-terminal region, HeLo, has a prion-inhibitory effect in cis on its own prion-forming domain (PFD) and in trans on HET-s prion propagation. The domain is found exclusively in the fungal kingdom. Its structure, as it occurs in the HET-s/HET-S proteins, consists of two bundles of alpha-helices that pack into a single globular domain. The domain boundary determined from its structure and from protease-resistance experiments overlaps with the C-terminal prion-forming domain of HET-s (PF11558. The HeLo domains of HET-s and HET-S are very similar and their few differences (and not the prion-forming domains) determine the compatibility-phenotype of the fungi in which the proteins are expressed. The mechanism of the HeLo domain-function in heterokaryon-incompatibility is still under investigation, however the HeLo domain is found in similar protein architectures as other cell death and apoptosis-inducing domains. The only other HeLo protein to which a function has been associated is LopB from L. maculans. Although its specific role in L. maculans is unknown, LopB- mutants have impaired ability to form lesions on oilseed rape. The HeLo domain is not related to the HET domain (PF06985) which is another domain involved in heterokaryon incompatibility.
Statistics
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PSSM-Id: 521221
Aligned: 89 rows
Threshold Bit Score: 113.166
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009153512    8 AIA---SlSFQVFGGCVKGFVL-LSRAHNLGKDASLLQTMLNLEEYRFIQWARAVGLISDEeeeqeqeqttsaedtgtgt 83  
XP_011320956    9 GSV---A-LVSLFKDCIDLYSM-ISAARELDEDAPILNIKLGVEKMLFLQWSDGVGLLEHAk------------------ 65  
XP_023426924    9 GAV---A-LVSLFKDCVDLLSM-ITAARDLGKDAAIMNTKLDVEKMLFLQWSDRVGLLKQGsa----------------- 66  
10_pfamImport   5 GAV---A-LVSLFKDCVDLFSM-ITAARDFGKDAAILDTKLDVERMLFLQWSERVGLLKQDs------------------ 61  
XP_003040568   10 GVL---G-LLGTFENCVELFAY-FSASRSLGRDYEFLEIGLDLEKSSLLQWAERVRLASSD------------------- 65  
XP_009225909    9 GVV---G-LAGLFKSCIDLLSL-VSATRSLARDYEIVFAKFELEKACLLQWARQVRLLDREc------------------ 65  
XP_023425374   10 GVLglaG-LIGAFKDTIDVFNT-VVDMRHMGRQYQVLDIKLDIEKALLLQWADRVKLLQAD------------------- 68  
8_pfamImport    3 GVA---G-LIGAFKDTIDLFGL-LADARDLGRDYEILKIKFDIQKTLLLQWSDRVGLLRTNd------------------ 59  
XP_003041311   10 GAVgvaG-LIGAFKDTIDLFGL-LADSRGLGRDYEILQIKFDIQKALLLQWTDRVGLLHECd------------------ 69  
EMD95681       43 GTL---A-LVGVFGDCVELLSYsIETAKSMGQHYVALATRLEIQRKLLHQWANRLKIFDPEh------------------ 100 
XP_009153512   84 qsttdtatsstankakdgSGTTtivrvsqKSprKTNTTtldprlnYaLAAELMGQLERLLST-DQLRKRYKLDLseQPQQ 162 
XP_011320956   66 ------------------FDTT-------FN--DLATR-------E-TI------LSILLSNaQALQDTYGLVK--H--- 99  
XP_023426924   67 -----------------sTNAL-------LC--SPDNR-------Q-IVSRVLESIKALLSEgQALQRDYGLKR--Vekv 110 
10_pfamImport  62 ------------------TNTL-------SC--DEDTR-------Q-IVSRVLESVKNLLSEsQALQRDYGLKK--VDVT 104 
XP_003040568   66 ------------------YDKR-------LD--DKTTQ-------D-AVLSALTAIRVLLSEsSSLQARYGVEI--DRGQ 108 
XP_009225909   66 ------------------YDRR-------LD--DPATF-------A-VVRQTLSSVQLLMTEcSTLKERYGLR------P 104 
XP_023425374   69 ------------------HDVR-------LN--EPNTQ-------T-LVLRILGSVRSLLTDaDQLQKRYGLRL--ENDT 111 
8_pfamImport   60 ------------------YDPL-------LD--QAHIR-------E-AIGETLSCIRLLLTDgTALRSKYGIDV--VDDQ 102 
XP_003041311   70 ------------------YDPC-------LD--QAHIQ-------E-AIGQILSCIRLLLTDaSALKSKYGLSQ--MDDE 112 
EMD95681      101 ------------------YDKR-------LD--DPNIE-------P-LIYQGFSWIRQLLQDgHKLEQRYSVRP--AKIH 143 
XP_009153512  163 PTGkqvdddnplspvyspitttttatttsatgaptatatsttnnptpLQRLVSDKLRKRILARAKLIQd----------- 231 
XP_011320956  100 SSPtvspas--------------------------------dstpieQFNEASENRLSRFLGDFNKFKvthsge--smqp 145 
XP_023426924  111 gt-----------------------------------------eptaGYQGASSFRFAKFLKQFEELNikpcqtsdadqh 149 
10_pfamImport 105 RPTtehpl----------------------------------tdsttGYKGASSHRFARFLKQFEALKiqatda---dry 147 
XP_003040568  109 AKTsa----------------------------------------lsVSSPVSHRSLNKFQDRVASLKkrme------lr 142 
XP_009225909  105 ADPssfs-------------------------------------fdpRFAPISKHPLERFADEFRSLKirvg------dr 141 
XP_023425374  112 ETPisaglepdfsylpsrlls--------gpislqhvssgqqrdqsqSGWRFSQKRMKSFVKRLEALPvpeq------gq 177 
8_pfamImport  103 VGAsh----------------------------------------ltSVSSISAWRMGVFKNQYDDFKkrma-------q 135 
XP_003041311  113 APVse----------------------------------------itSIPSISAWRMRVFNSQYEEFKrria-------q 145 
EMD95681      144 ESMe-------------------------------------------SPTAFRHWLMSKFNSMPHKLRsrr--------d 172 
XP_009153512  232 --DNHLPKRLWWAAVDKKKFEDMVKDVRVLVDGLWALLD--------PIqRRDS--SWLLNEVlarMVQLSkDVGELR 297 
XP_011320956  146 srIHKAVKQFRWVVVPKGKFDGLINHLSYFNGALNSLAPr------vSN-STF----DLSSED---LSYVD-SISQLD 208 
XP_023426924  150 snFKKFTKQFRWIIVDKDKFNSLIDHLSYFNTSLNNLIPm------pSV-SET----TFSKNE---LIHLK-NLAEld 212 
10_pfamImport 148 skFKRTTKQFRWVIVDKDKFNYLIDHLSYFNTSLNNLVPl------sVE-SET----APCEND---MIHIK-DFAELD 210 
XP_003040568  143 qsRTSPVSKIRWVVSDKDKFTELIRELSKFVAKLHHFVPllsentslAGtEPSHgpDGMIRED---LRGIN-EVRKLR 216 
XP_009225909  142 paGVALPGRIKWALTDKAKFETLVHGISHFVSKLHELFPdcg---prDS-SDGL--KRIVTQD---LGEIH-DTRLLr 209 
XP_023425374  178 vtTTSIAQKTRWVIRDKQKFEVLIQDLAELTTKLDQVVP--------PSnSETA--RSMIQSD---IELIKkDVRKLL 242 
8_pfamImport  136 gnEMPFRSRALWAVRDKTKFQVLVADLADLITTLDRLIPv-------TRkQPAL--QTLVDDD---VRRIS-GLSNLK 200 
XP_003041311  146 rnDKPFRTRARWAVRDKQKFEGFVRDLADFISSLDKLTPv-------TRgQPSL--QNMADDD---VKTIR-GLPGLK 210 
EMD95681      173 vqSLQPYQAVRWIIQDKEQFESLFQSLSDLIADINAVIP--------PQrGDST--NTALQHE---AANLS-SVSELG 236 
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