4A2A,2YCH


Conserved Protein Domain Family
FtsA
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pfam14450: FtsA (This model is not part of the current CDD release)
Cell division protein FtsA
FtsA is essential for bacterial cell division, and co-localises to the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains. The FtsA protein contains two structurally related actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain PF02491 inserted in to the RnaseH fold PF02491.
Links
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Statistics
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PSSM-Id: 521210
Aligned: 358 rows
Threshold Bit Score: 34.2124
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4A2A_A        209 VVVNLGYNFTGLIAYKNGvpiK----ISYVPV---GMKHVIKD-------VSAVLDTSFEESERLIithgnavyndlkee 274 Thermotoga mar...
WP_013047199   15 AVLDLGSSKVTCLIGEAD---Gkg-kVQLLGQgmhASAGMRHGevsnlelLSTVIGKTVHAAERDA-------------- 76  Candidatus Pun...
Q2GFA8         16 AVVDLGSTKIVCFIVRIS---Hnn-dFEIVGIgykAAEGISGGaiidiesAKCSILSCIESAKEMA-------------- 77  Ehrlichia chaf...
WP_011944781    9 VSIDIGSSKIAAVASYVE---Nng-lISVVSQgfyYSSGIKSGiisdfkkAENSVISAIYNLEKDL-------------- 70  Orientia tsuts...
WP_013951675   10 AVLDIGSSKILCSIAKFS---Sss-eLEVIGYsnhISEGIRSGiitnlqaATESIAQAIEEAEKNS-------------- 71  Candidatus Mid...
WP_025227990    7 TVLDLGSTKVACLVAAP----DgvdgMQVVAVattPSKGIRKGvvadldeASVGIDVVFRRVEQEI-------------- 68  Fimbriimonas g...
12_pfamImport   1 LGLDIGSIDIKAVIAKS----Dtn-gLSICGFglaKTTGVKKGvitnieqASNCIRKAVFDATNTA-------------- 61 
Q0PAI4          6 LGIDLGSTQTCAIIAQK----Ded-gLKIIGFsksKTNGVKKGaitnielASKSIEEAVRSAEMMS-------------- 66  Campylobacter ...
38_pfamImport   1 LAIDIGSTDVTAIIAKN----DldykINILGTgieASDGINKGlitnielASKSIQNAVLKARRST-------------- 62 
59_pfamImport   1 LGVDIGSSKICAIIAEI----Kdg-tPQVIGAsvqKSEGVRKGsisnisqAGEIVKKAIEDAKRMA-------------- 61 

4A2A_A        275 eiqyrgldgntikttTAkKLS----------------------------VIIHARLREIMSKSKKffrEVE---A----- 318 Thermotoga mar...
WP_013047199   77 ---------------GT-SIQsmsivtpggmpvs---rlgkqtltlsdkTVRRRDMQRLMAREND---ADTp-dShqamh 133 Candidatus Pun...
Q2GFA8         78 ---------------QEpVISqvfvnvsgcdiss---msvvneidammhEVSDVDIRNIMLQTYD---KCRd-eQvvl-h 134 Ehrlichia chaf...
WP_011944781   71 ---------------GK-TIKhvtislsnvctks---yytyskikiatqYVTKQDIIKLISKALY---NFKi-qNqeiih 127 Orientia tsuts...
WP_013951675   72 ---------------GI-RVSniyvnissnnlis---hqlsaeidvtgrEINSKDMNKLLFQVLD---KYKd-qQvgvih 128 Candidatus Mid...
WP_025227990   69 ---------------Gq-EIGsvivgvsgahtegl-naqgfkpiiprgrLITHQDVLEVLNHSRA----LVlppDreqlq 127 Fimbriimonas g...
12_pfamImport  62 ---------------G---RHydkvvvsisgaytk-svksqgvitvpdnEISINEIRRAMEVAKD---TANvpnNyvklq 119
Q0PAI4         67 ---------------G---VHydrvvvsisgaytk-svdsigvvnipnhEIGIKEIHRAVSTAKH---TANlpsGyeiih 124 Campylobacter ...
38_pfamImport  63 ---------------S---EPiestvvaisgsytk-girsmgsvnvpngIITEHEINQVMQMALY---NATivpEyevvh 120
59_pfamImport  62 ---------------G---LDfvekaivsisgaytqsvnssgiinvpnnEITLKEINRALDTALH---NAAipsGhevih 120

4A2A_A        319 --K---------------IVeEGEIGi-pGgvVLTGGGAKIPRINELATEV---------FkspvrtgcyansdRPsiin 371 Thermotoga mar...
WP_013047199  134 lqTlqydlddvrgiadprGMrGSALSvdyT--IVSGARTSLTNFREALVLNhlev-drfiH-------------AG---- 193 Candidatus Pun...
Q2GFA8        135 niPvvyrlddlnnitelkGLyGSKLKasmH--VVTASKSALLNIENCITNCsdlnvvgcvA-------------EP---- 195 Ehrlichia chaf...
WP_011944781  128 yfPiefsldnnnsiqdpiGMhGKELGcrlH--LISANSNVLLNIINCLAKCqvev-qevvL-------------SI---- 187 Orientia tsuts...
WP_013951675  129 sfIydyvldgnrgitnplGMyGSNLScevN--VLVTPNNIIANLANCLSKCqldv-nayiA-------------SS---- 188 Candidatus Mid...
WP_025227990  128 alPrefrvdgqrdvrkpiGMsGSKLEvvtY--IVTGQTSAIQNIEKAVTRAgkkv-eqmvL-------------KP---- 187 Fimbriimonas g...
12_pfamImport 120 ilPykfkvdeqdgiedplGMsGMRLEvstH--VIIVPENSIKNLTKSVEMAgini-dnivL-------------SG---- 179
Q0PAI4        125 vlPynfkvndlehvddplGMsGNRLEvstH--IVISQESHIKNLKKAVELAdlrv-dnivL-------------SG---- 184 Campylobacter ...
38_pfamImport 121 viPiffkvddsadvdnplNMnGARLEvsvY--IVTAKRTALTNLKSAFKESniei-tnfvL-------------NG---- 180
59_pfamImport 121 ilPyqfkldnqdniedpmGMsGSRLEvftH--IVTVQHSSLENLRRTIQLAgvki-enivL-------------SA---- 180

4A2A_A        372 adevandpsFAAAFG 386 Thermotoga maritima
WP_013047199  194 ---------YAAGLA 199 Candidatus Puniceispirillum marinum
Q2GFA8        196 ---------YTSGLS 201 Ehrlichia chaffeensis str. Arkansas
WP_011944781  188 ---------YASGLA 193 Orientia tsutsugamushi
WP_013951675  189 ---------YVSGMA 194 Candidatus Midichloria mitochondrii
WP_025227990  188 ---------LASGIG 193 Fimbriimonas ginsengisoli
12_pfamImport 180 ---------YASAIA 185
Q0PAI4        185 ---------YASAIA 190 Campylobacter jejuni
38_pfamImport 181 ---------YATAIS 186
59_pfamImport 181 ---------YAASIA 186
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