Conserved Protein Domain Family
DBC1

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pfam14443: DBC1 (This model is not part of the current CDD release)
DBC1
DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.
Statistics
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PSSM-Id: 521209
Aligned: 19 rows
Threshold Bit Score: 139.814
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002432401  426 HPSRLINCLVginSRAK-NE-IMAIGGPWSPSLDGTDPVGDPNVLIKTATRTCRALTGIDL--TPCTHWYRFVEIYYHRp 501 
1_pfamImport    1 HPTRLIKFLVg--QKGKgGE-NFAIGGPWSPSLDGENPQTDPKVLVKTAIRTCKALTGIDL--SSCTQWYRMVEFYYWRe 75  
XP_004362318  614 NLCKRLKFLV-----AKeNKdICCIGGTWSPSLDGQD-IDNPQTLINTAIRTTKEYTQFDL--SKCVKWIKFMEVHYYR- 684 
XP_020436692  556 HINKRLKFLV-----AKeNKdISCIGGSWNPTLDGND-INDPQTLINTAIRTTKEYTQIDL--SRCNRWVKFMEIHYYR- 626 
Q86A78        605 SITKKIKFLV-----SKeDKdISCIGGTWLPDLDGED-VNDPQTLINTAIRTTKEYTQIDL--SGCKKWYKFMEVHYYR- 675  Dictyostelium...
XP_003283394  384 SISKRLKFLV-----AKeDKdISCIGGSWNPELDGED-INDPQTLINTAIRTTKEYTQIDL--SSVKKWVKFMEVHYYR- 454 
XP_005845698  757 HLCRLLKFVVaraDRNGdKSgIFCLGGRCDPAMDG-DPTQGDAALVAAARRHVAAQARLELppAGAGAWLRFIEVHYTR- 834 
EFJ21962      589 SFQKMLKFVA----LRKdRNaIMAAGTRWDKSLDGGDPTVDDSGLIRAAVRSLKELIQLDL--SECKDWFRFAEVHYER- 661 
XP_006827314  556 HFNNILRFAI----LRKdRC-FTAVGGPWNGTLDGGDPSMDDSALIQTALRHTMATIQLDL--HNCQHWNRFLEIHYDR- 627 
XP_006573124  583 HFCNFLRFAV----LKKdHS-FMAVGGPWEPV-DGGDPSIDNNSLIKTALRYAKDVIQLDL--QNCQHWNPFLELHYDR- 653 
XP_002432401  502 rstHKgkqipARVETVVIYIPDVWSAMPSCLEWNELVLKLKNQMDKKLI 550 
1_pfamImport   76 gsgNK-----SRLECVVLFLPDVWSAQPSRIEWSSVQDQYKAACDAAIR 119 
XP_004362318  685 ---PPteknqQYQEVTVIFVPDISNITPNEINHSLLQQDKPSEKEEGED 730 
XP_020436692  627 ---PPteamaQFQEITVIFVPDLTNITPFDGKEHMKNKVTTASPTEKST 672 
Q86A78        676 ---PPteeqsYYQEITVIYVPDITDIQPMDVDSLLKVPTVSETTPSAPV 721  Dictyostelium discoideum
XP_003283394  455 ---PPtdefsFYQEITVVYIPNISEIPPLDVETLMKNNSKGLETDKQGe 500 
XP_005845698  835 ---LDrndveHHQEVTVVFMVDASRCLPSAADWPHVWQQQQKPVLLQKL 880 
EFJ21962      662 ---VDedgfpSHREISVIFFPDISSCVPSFENWCLQWNQRKQAKLEREG 707 
XP_006827314  628 ---IGkdgffSHKEITVLFLPDLSDCLPSLDAWRSLWLARRKEKIERER 673 
XP_006573124  654 ---IGkdgffSHKEITVLYVPDLSDCLPSLDEWRDKWLAHKKAVAEKER 699 
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