3L4C,6TGB,7CLY


Conserved Protein Domain Family
DOCK-C2

?
pfam14429: DOCK-C2 (This model is not part of the current CDD release)
C2 domain in Dock180 and Zizimin proteins
The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.
Statistics
?
PSSM-Id: 521206
Aligned: 165 rows
Threshold Bit Score: 84.9536
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3L4C_A         22 PGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDED--GKRLehvIFPGA--GDE-AIS-EYKSVIYYQVKQPRWFET 95   human
Q20487        586 NKSYKNVIFVYPKHINLSNR-TGNARNIMIKIELMDAN--ETAQe-vVFENGstRMS-FLT-SAKTSVIYHNRTPHFTDE 659  Caenorhabditi...
XP_007231918  482 HSIYRNLLYVYPQKLNVSSR--GNIRNITVKIQFMNTEdpSGALp-vIFGRS--SGPeFVS-EIYTPITYHNRSPDFYEE 555 
XP_006626930  551 HTTYRNLLFVYPQRLSFANR-LASARNISVKTQFMCGEdaSSAMp-vIFGKS--SGPdFVQ-EVYTPVTYHNKAPDFYEE 625 
XP_012808011  552 HTIYRNILYVYPQRLNFANR-LSSARNIAIKIQFMNGEdaKNAMp-vIFGKS--SGPeFLS-EVTTAVTYHNKTPDFYEE 626 
XP_048582972  596 FVIYENLLYIYPQSVNFSSR-GTSARNIACKVQIMSGEdeQNCIe-cIFGKS--SCA-SMSkEAYTHVTYHNRTPDFNEE 670 
7CLY_A          9 HTVYRNLLYVYPQRLNFAS-KLASARNITIKIQFMCGEdpSNAMp-vIFGKS--SGPeFLQ-EVYTAITYHNKSPDFYEE 83   house mouse
XP_028908414  549 HTTYRNLLYVYPHSLNFNSR-QGSVRNITVKVQFMAGEdsSQAMp-vIFGKS--SCSeFTK-EAYTAVVYHNKSPEFYEE 623  platypus
XP_047295083  555 HTSYRNLLYVYPHSLNFSSR-QGSVRNLAVRVQYMTGEdpSQALp-vIFGKS--SCSeFTR-EAFTPVVYHNKSPEFYEE 629  human
XP_011613887  550 HNIYRNLLFVYPQRLNFVNR-LTSARNITIKIQFMSGEdpACALp-vIFGKS--SGSeFLH-EVYTPVTYHNKSPDFYEE 624  torafugu
3L4C_A         96 VKVAIPIEDVNRSHLRFTFRHRSSq-DSKD----KS-EKIFALAFVKLMRydGTTLRDGEHDLIVYKaEAkkleDAATY- 168  human
Q20487        660 IKLSLPCDLNDGHHLLFTVYHISC----KEgdssST-ESPIGYTWLPLYRngK--LRSGNFHLPVCG-EK----PPPRY- 726  Caenorhabditi...
XP_007231918  556 VKIRLPARLTEKHHLLFSFYHISC--QQKQnqsgSV-ETLVGYSWLPILNneR--LQIGQHCLPIAV-ER----LPVNYs 625 
XP_006626930  626 VKIKLPAKLTERHHLLFTFYHISC--QQKQtqagNV-ETLIGYSWLPIVTndK--LQVGQHCLPIAL-Dr----LPSNYs 695 
XP_012808011  627 VKIKLPAKLTNRHHLLFTFYHISCq-SKQGa---CV-ETLLGYSWLPMLLndR--LQIGQYCLPVAM--Ek---LPLNYs 694 
XP_048582972  671 IKVKCPAHLTDQHHILFTFYHISCs-PGKKpdekEV-ETPIGYTWIPMLKdgR--LALGEFNLPVSL-Dk----PPHSYs 741 
7CLY_A         84 VKIKLPAKLTVNHHLLFTFYHISCq-QKQG----ASgESLLGYSWLPILLneR--LQTGSYCLPVAL--Ek---LPPNY- 150  house mouse
XP_028908414  624 FKMKIPANLTDNHHLLFTFYHVSCqqKQNT----PL-ETPIGYTWVPLMQhgR--LRTGPFCLPVSV-DK----PPPSYs 691  platypus
XP_047295083  630 FKLHLPACVTENHHLLFTFYHVSCqpRPGT----AL-ETPVGFTWIPLLQ--HGRLRTGPFCLPVSV-DQ----PPPSY- 696  human
XP_011613887  625 VKLALPACLTERHHLLFTFYHISC--QQKQnqsgSC-ETLIGYSWLPVLN--NERLQMGQFCLPIAL-ERl----PLNYs 694  torafugu
3L4C_A        169 LS-LPSTKAELEEK---GHSATGK---SmqslgsctiSKDSFQISTLVCSTKLTQNVD 219  human
Q20487        727 GY-LD-------AN---NALPNLKwvdN---------HKPIFSCSTEVISSVHAQDEF 764  Caenorhabditis elegans
XP_007231918  626 MH-SP-----EKMP---TQIPPMKwmdS---------HKGLFSLEVQSVSSVHIQDSH 665 
XP_006626930  696 LH-SP-----EKVP---LQNPPVKwveG---------HKGVFSLEIQVVSSVHTQDNH 735 
XP_012808011  695 MH-TPEKVPGQSPP---IKW--VE---G---------HKGVFDLEVQAVSSVHTQDNH 734 
XP_048582972  742 ML-SP-----E------VQLPGMKwveG---------HKGVFHVAVRAVSSIHTQDPY 778 
7CLY_A        151 SI-HSA----EKVP---LQNPPIKwaeG---------HKGVFNIEVQAVSSVHTQDNH 191  house mouse
XP_028908414  692 VL-TP--------D---VQLPGMKwvdN---------HKGVFNVEVLAASSVHPQDPH 728  platypus
XP_047295083  697 SVlTP--------D---VALPGMRwvdG---------HKGVFSVELTAVSSVHPQdpy 734  human
XP_011613887  695 LH-TP--------EklpLQVPPVKwmeS---------HKGLFNLEVMAVSSVHTQDNH 734  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap