Conserved Protein Domain Family
Toxin-deaminase

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pfam14424: Toxin-deaminase 
The BURPS668_1122 family of deaminases
A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Burkholderia BURPS668_1122. Members of this family are found as toxins in polymorphic toxin systems in a wide range of bacteria and in the eukaryote Perkinsus. Members of this family typically possess a DxE catalytic motif in Helix-2 of the core fold instead of the more common C[H]xE motif. The Perkinsus versions are predicted to be inactive.
Statistics
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PSSM-Id: 464170
Aligned: 6 rows
Threshold Bit Score: 147.349
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q87U34       1386 SIVTPQAPKRimkqvrGANLSFLQAYteSGERIVYYALSGGNKAKDlklqlDVTESTERVIDGViyrdararmagrqpDP 1465 Pseudomonas s...
CDA91717      441 RTMFTSKFKK------SGNIAGAYID--GDKSNMYFAHSRLSDSTK-----GYKGKSNLVLLKD--------------KR 493 
1_pfamImport    5 RLVLPSGPKT------GGNMGIAQIDipGIP-STMAASSQIN-------------------TPTitqqalg--fvgqvpe 56  
Q81R60        337 RGNLSSKYKK------SGNFAVAEVDvsGISKSEFYAQSSINELKG-----SLEHK-----VPDisl--------qpeNP 392  Bacillus anth...
WP_014372361  216 RQELPKEIQK------TGNFGLAEVKieGLR-TEFKSHSRVNELKD-----AGNAEGYSVLKPDp------------kDW 271  Paenibacillus...
WP_015392428  250 KINQSKALQD------SINIALATYD-----NKEFKAISGSNNIVD-----------YCVAPKEe-------------EA 294  Clostridium s...
Q87U34       1466 GFTSLPVIRDVDHLVVRSFGrylDSERLIATVLKEDMA----STKLTHIKVFTVLDTCRSCGGfVLPRLKLDFPDAQFSV 1541 Pseudomonas s...
CDA91717      494 RFSYIDVIDKDNSIRGETYQ---DTEAKLFEYFADLYE----KKPFKSITMLSERGMCDSCKG-VMKQFSKQYPKVQINV 565 
1_pfamImport   57 TFTSSAVPSASGVL----INravDSEAKILNNVAARLGd--nTSVAGTINLLTERAPCSSCSN-IIQQFQTKYPNIIINV 129 
Q81R60        393 MFKATEAVGKNGFN----YLrntDTEYKILNDIASRLGd--nTQASGRIKLFTELDTCDSCNK-VIAEFAAKYKNIELEV 465  Bacillus anth...
WP_014372361  272 NFTPQEVNTKDIINGEGAYSrkwDTEFKIIEDITDQLKalkpEQRKGSIDIYTDREPCASCGP-ILEQFKARFPDIQVNV 350  Paenibacillus...
WP_015392428  295 VFKSNKVNKLGELGIG--YNrvnDSEKKILEEIHKQIEek-tLKDEGDLILLSKWEPCPSCYF-VISQFCKMHPQIKVQV 370  Clostridium s...
Q87U34       1542 TYLK 1545 Pseudomonas syringae pv. tomato
CDA91717      566 ISNK 569 
1_pfamImport  130 MDNN 133 
Q81R60        466 VHNN 469  Bacillus anthracis
WP_014372361  351 Yfak 354  Paenibacillus mucilaginosus
WP_015392428  371 KYSK 374  Clostridium saccharoperbutylacetonicum
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