7CV1


Conserved Protein Domain Family
Thg1C
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pfam14413: Thg1C (This model is not part of the current CDD release)
Thg1 C terminal domain
Thg1 polymerases contain an additional region of conservation C-terminal to the core palm domain that comprise of 5 helices and two strands. This region has several well-conserved charged residues including a basic residue found towards the end of the first helix of this unit might contribute to the Thg1-specific active site. This C-terminal module of Thg1 is predicted to form a helical bundle that functions equivalently to the fingers of the other nucleic acid polymerases, probably in interacting with the template HtRNA.
Links
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Statistics
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PSSM-Id: 521200
Aligned: 87 rows
Threshold Bit Score: 156.542
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7CV1_A       146 QTLKDYLSWRQADCHINNLYNTVFWALIQ--QSGLTPVQAQGRLQGTLAADKNEILFSEFNINYNNELPMYRK------- 216 human
XP_006677557 138 LNLKDYLSWRQADCHINNLYNTAFWALVLdpKEPKSETEAEAILRVTDAAAKNELLFSRFGINYNTIDPLFRK------- 210
Q4UGI9       163 RAVVDYFSWRHVDCHINNQYNTCFWCLIL---DGKSNDEAYNWLKGTTKVEKNEYLFTTHKLNYNNLPNIFKK------- 232 Theileria annulata
XP_024380966 138 SILRDYLSWRQVDCHINNQYNTCFWNLV---GSGKSTAESQNMLKGTTADVKNNLLFDTFKINYNDLPQIFRK------- 207
XP_010652868 404 EILRDYLTWRQVDCHINNQYNTCFWMLV---KSGKSKSEAQAYLKGTQAREKNEVLLQQFGIDYNTLPLMFRQ------- 473
XP_002862851 404 DILLDYLAWRQVDCHINNQYNTCFWMLV---KSGKSKTQAQDYLKGTQTREKNELLIQQFGIEYNSLPVIFRL------- 473
XP_004961388 139 KTIRDYLAWRQVDCHINNQYNTCFWMLV---KSGKSEQEAQLALKGTFAKDKNELLAQQFQINYDDEPAMFRK------- 208
XP_024315113 139 KTILDYLAWRQVDCHINNHYNTCFWMLVM---SGKTEKEAQQTLKGTFSKDKNELLSQQFQINYDNEPAMFRK------- 208
XP_005851420 172 HTLRDYLSWRQADTHVNNLYNTCFWALV---KSGKSTGEAHEQLRGTLSDYKNELLFSQFGLNYNTLPERFRKpascgcg 248
XP_001693575 138 SNLRDYLSWRQADTHINNQYNTCFWALV---KSGKTPTEAQATLRGTQTAQKNELLFNEFGINYAHLPEQFKK------- 207

7CV1_A       217 -------GTVLIWQKVDEVMT----------------------------------------KEIKLPtEMEGKKMAVTRT 249 human
XP_006677557 211 -------GSVLFR------------------------------------------------QKTKSVeKIREDGSPVMRD 235
Q4UGI9       233 -------GTTLVKSTTKAVNVddenclnyntfdqldnlsrrefseglgedlvdkerkiwleISPSEL-NELEFKVKEKAS 304 Theileria annulata
XP_024380966 208 -------GSIVYR------------------------------------------------KKVEKV-VKVEDGQEIKRL 231
XP_010652868 474 -------GSSAFW------------------------------------------------NEEEKT-GMYENGASAEKS 497
XP_002862851 474 -------GSSVFR------------------------------------------------LKTQEG-VAEENGEVSGKQ 497
XP_004961388 209 -------GSSVYR------------------------------------------------EKVETTvKIDDYGNPIKRP 233
XP_024315113 209 -------GSSVYR------------------------------------------------EKVETKlKTDNYGNPIKRT 233
XP_005851420 249 clvavlqGSIVIR------------------------------------------------QRVMHV-KQTADGGTKEKE 279
XP_001693575 208 -------GSVVIR------------------------------------------------RKTMVEvKQRADGTPVLRE 232

7CV1_A       250 -RTKPVPLHCDIIG 262 human
XP_006677557 236 -RSEIKTEHVDIIG 248
Q4UGI9       305 -EHNILVLHCDIVK 317 Theileria annulata
XP_024380966 232 -RSCAVVEHEDIIR 244
XP_010652868 498 -GKKVVVEQCNIIE 510
XP_002862851 498 vEAEVVVDYSNIID 511
XP_004961388 234 -RLKVTVAHIDIIG 246
XP_024315113 234 -RMAITVSNVDIIG 246
XP_005851420 280 -RLEPCVLHCDIIR 292
XP_001693575 233 -RNLPTVLHTDIIR 245
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