Conserved Protein Domain Family
AHH
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pfam14412: AHH (This model is not part of the current CDD release)
A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4 conserved histidines of which, the first one is predicted to bind a metal-ion and the other three ones are involved in activation of a water molecule for hydrolyzis.
Links
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Statistics
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PSSM-Id: 521199
Aligned: 53 rows
Threshold Bit Score: 54.0641
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2SED4                115 TLVEVNNFTTGFAPYGNQVHHIVNISSVRNGIEEIAkdlpdlrvlivnglLDEKYNINYK---DNSLIL----------- 180  Hahel...
WP_015487352           72 LGKFLRISGFSRPGPKWEAHHIVSTIHREAVAMRLLi-------------ADDDFSIRIDd-pDNGTWMpktkadarati 137  Thala...
WP_015046593           76 IGGHMETSGYDKPADHFHAHAIVSGGHKRAYAARE---------------ILAQFNIRIDe-pANGLWL----------- 128  Simid...
WP_276677921           77 LGRFLETVQYVRPDSNFEAHAIVSGGHARAIAARE---------------ILAQYQLRIDd-pTNGVWL----------- 129  Thala...
WP_022744139           41 ELSRNLSREGRPVGNGEVAAHIVASTEEKRQWAKVAds----------rkILDKYGVNINd-aANGIPL----------- 98   Clost...
WP_005372621          714 LTKNIADARQEVKQKGESAHHIVAAGDFRAEGSRQ---------------ILENAGMDINd-aNNGLLM----------- 766  Methy...
Q82R58               2255 ILGDNMTAAGTIRPAETAAHHIVASASPKAASARA---------------KLASVGIDINd-aDNGVFL----------- 2307 Strep...
Q81H88                 21 LEHGGKDAGVEPPPYSNAAHHLTPWNDKRAIEAQE---------------LLKEFGIHHDs-aANGVFL----------- 73   Bacil...
goetting:CLSA_c07970   91 RGELKTSGNMQTPPYGNAAHHIVAAKEEDAKIARD---------------ILKEYSVDVNs-aSNGVFL----------- 143 
Q97IJ7                201 NYLKKKRGNPPSGMSKPHAHHVAVKGNFSNRKKIIQtyak------ysseVLKSVGIDPYygiENIHWA----------- 263  Clost...

Q2SED4                181 -Pt--QRSASAKTGLPSHYGSH-----PSYSKDIlqhvKQALQPYKKIANEMKKNKPHSKPDpvelkkkledaSKKLYKE 252  Hahel...
WP_015487352          138 yP-----------DAIGHNRIHr----QRYYRWL----ENTVTAFDDGAQVRAF-------------------LNTVRVQ 179  Thala...
WP_015046593          129 -PnykKNLHLSPIFDCAHGNIHn----KIYYLNI----TACLEQAMSQQHAREI-------------------LRRVAQG 180  Simid...
WP_276677921          130 -PnfkKNLSGYPDFNYAHRPLHr----KIYYLNI----TSCLEQAMSSAHARVI-------------------LRRIAQG 181  Thala...
WP_022744139           99 ----------------AHPRPHnithrAGFHEMV----NTRLTSVVNNMTSLNYGRKAIRSAlr-------keIRKIGRE 151  Clost...
WP_005372621          767 -------------HTMYHERIHt----NEYYRAV----DESLRGASTYNEVASR-------------------LSNIRAE 806  Methy...
Q82R58               2308 -Pr--GSASPNLTGASVHSRIHt----NNYYGYV----NDMMSGVRTANEARDV-------------------LNHIRNQ 2357 Strep...
Q81H88                 74 -P---YKVNEYVTTEVLHIGNHc----TDYMKEV----TKVLKEVKEYGGTQADAVAA---------------LHDIRIR 126  Bacil...
goetting:CLSA_c07970  144 -PygkKETNSYITTETTHNGSHt----GDYYKYVnnklQQTIEEIETNGGTVTSKDITKT-------------LDDIRKG 205 
Q97IJ7                264 -P---------------NEG-Hs----NRYIKAI----AKEFYEVKKLGGNKDDFVNK---------------ILDIVDK 303  Clost...

Q2SED4                253 I 253  Hahella chejuensis KCTC 2396
WP_015487352          180 L 180  Thalassolituus oleivorans
WP_015046593          181 I 181  Simiduia agarivorans
WP_276677921          182 I 182  Thalassolituus oleivorans
WP_022744139          152 T 152  Clostridium saccharobutylicum
WP_005372621          807 I 807  Methylomicrobium album
Q82R58               2358 L 2358 Streptomyces avermitilis
Q81H88                127 L 127  Bacillus cereus ATCC 14579
goetting:CLSA_c07970  206 L 206 
Q97IJ7                304 L 304  Clostridium acetobutylicum
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