Conserved Protein Domain Family
GH-E

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pfam14410: GH-E 
HNH/ENDO VII superfamily nuclease with conserved GHE residues
A predicted nuclease of the HNH/EndoVII superfamily of the treble clef fold which is closely related to the NucA-like family. The name is derived from the conserved G, H and E residues. It is found in several bacterial polymorphic toxin systems. Some GH-E members preserve the conserved cysteines of the treble-clef suggesting that they might represent potential evolutionary intermediates from a classical HNH domain to the derived NucA-like form.
Statistics
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PSSM-Id: 494252
Aligned: 16 rows
Threshold Bit Score: 57.8951
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_006055088   324 DDKVRDPNTE-EVlTwdkdRGRGEQWHMGHKKQR-EYRYLLEYYQQ--GIISEEEFVKEYQ-NPDHYQAEAPRENMGRRH 398  Halogeometri...
WP_013223320  1449 NGN--------------------RNLTYEHVPPVvEHWRDEG------HNMTDEERKAWYN-NTDDMEAMGRSQNSSEGA 1501 Amycolatopsi...
jgi:Bphy_7307 2950 DGTKACPTCGkdvt--vapGQGARDWDVDHQPPW-SQRDL--------TGMTRQEVINEYN---SGTRLECPSCNRSRGA 3015
WP_012648266    91 EGV-----------------------QIGHRR---KWRDELKHA----GVITPSEAKAAFN-NLRNLRVECSTCNQSHDW 139  Geotalea dal...
WP_022410096   206 NGQIVSPNGTgQViDg------NVQTDIGHVNSF-ENKYEVKYSEK--AGLTQQEHNQMFS-NPGQFQVEPSRENRSHAF 275  Ruminococcus...
P45942         453 TGSVKDPLTK-QVmK------KDEPWDMGHKPGY-EFRKHQQSAME--RNISRKQFLDEHN-NPDHYQPELPSSNRSHKG 521  Bacillus sub...
1_pfamImport     1 GGFTIPKPNPhs------kTGLPANYHFGHVQGS-EYWRLVRIVEDhpGKWTWKQILDEYN-KPSHYQVEDPSTNVGHGS 72  
WP_015924986  1272 NGTFFDANTL---------LPIEGTPDIGHVYGR-EFWRERDKAED--KGWTQSQFNDYMN-NSEFYQFEDPKSNRSHQF 1338 Ruminiclostr...
WP_013139685   425 EGRKYPVDPV---------------WHYGHEYDR-EWWRLQEEARSanPPWTQKQMNDYVNdHPEIFRIEDAPGNVSHAH 488  Segniliparus...
WP_013137253   430 DGTLYPVNTQ---------------IHIGHIKYS-EWARLRNDAIA--KGWTERQLQEYIQ-NHKLYQIEDAYGNLSHQY 490  Segniliparus...
WP_006055088   399 E 399  Halogeometricum borinquense
WP_013223320  1502 Q 1502 Amycolatopsis mediterranei
jgi:Bphy_7307 3016 N 3016
WP_012648266   140 E 140  Geotalea daltonii
WP_022410096   276 E 276  Ruminococcus sp. CAG:330
P45942         522 E 522  Bacillus subtilis subsp. subtilis str. 168
1_pfamImport    73 E 73  
WP_015924986  1339 E 1339 Ruminiclostridium cellulolyticum
WP_013139685   489 E 489  Segniliparus rotundus
WP_013137253   491 E 491  Segniliparus rotundus
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