Conserved Protein Domain Family
EDR1_CTR1_ARMC3_pept
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pfam14381: EDR1_CTR1_ARMC3_pept (This model is not part of the current CDD release)
EDR1/CTR1/ARMC3, peptidase-like
This entry represents a peptidase-like domain mainly found in proteins from plants, including serine/threonine-protein kinases EDR1 and CTR1 from Arabidopsis thaliana. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation. CTR1 acts as a negative regulator in the ethylene response pathway. It phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene. This entry also includes proteins from animals, such as ARMC3, which is essential for male fertility and sperm motility. During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility.
Links
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Statistics
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PSSM-Id: 521186
Aligned: 43 rows
Threshold Bit Score: 215.124
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_194179    277 STESISYRFWVSGCLSYS---DKISDGFYSILGmdpylwlMCNNSEDGKRIPSLLLLKETEPn-DTSMEVVLIDRREDSR 352 
XP_001420846  35 KGQSLASKFWISQALDADevlDETCDGFYDVWG-------DAFESSVDGQLPALGDLLKRPPv-TATEEVFVVDRRTDMF 106 
EFJ07496      40 PAVFTSHRFWVHGSLGYS---DRIDDGFYYVHGidpyvwaMCTDVDDKGRMPTLDALRAVDIs-QVSLEAVYIDRSCDSS 115 
XP_002530885  72 SAESVSHRFWVNGCLSYY---DRIPDGFYVIHGvdpyawtISIDQKDIGLIPSFESLKALDPrdDLSVNVVLIDRFRDPS 148 
XP_014623204  66 SAQTLTHRFWVDGCLQYS---DKIIDGFYLIHGmdvytwtISTDLQNVGMIPSFESLMSIEPsdDLSILVVAVDKSRDPG 142 
XP_004233031  56 ASKRASQILWDTGELA-----EPIPDGFYFVIPerr-------fkELFDTIPSLDDLYALETe-GLRPNVILVNMHKDKK 122 
Q94AB2        56 PSSTASNILWSTGSLS-----EPIPNGFYSVIPdnr-------lkQLFNNIPTLEDLHALGDe-GLKADVILVDFQKDKK 122  thale cress
EFH58123     112 SSYEASNILWSTGFFS-----DPIPSGFYSVIPvd--------rlQLFKSIPTMEVINALGKe-RFKADAICVDLKNDIQ 177 
NP_001324376 125 SSYEASNIFWSTGSLS-----DPIPSGFYTVIPve--------rlMHFKSIPTLEEINALGEd-RLKADAIFVDLKNDIQ 190  thale cress
NP_180658     48 PGQRASQHLWDTGILS-----EPIPNGFYSVVPdkr-------vkELYNRLPTPSELHALGEe-GVRIEVILVDFQKDKK 114  thale cress

NP_194179    353 LKELEDKAHELYCSSDNMl-vLVEKLGRLVAVYMGGNFQVe-QGDLQKRWKLVSNRLK--EFRKCIILPIGSLTMGLCRH 428 
XP_001420846 107 LNALDELARETCSQVPNVr-aRCAALARLVSDRLGGSVKTidDPTLVLATAEDREQLLnaSSQSGCCLHVGHLSKGVERH 185 
EFJ07496     116 LCEHEKTAVAIGYECSNAs-eLPERLGKFVSNVMGGKASNg-EGELISHWITRSRKLK--DALHSAVIPIGTVRIGLCWH 191 
XP_002530885 149 LKELSNRVIKLSSNWITTk-dAIDQLADLVCNRMGGVTSTe-QNTFDMCWKECTEILR--NRLGSVVLPIGNLPVGLCVH 224 
XP_014623204 143 LRELQNRVASLSNNWITTk-dATDQLANLVCNRMGGGSLT--EENLGTRWKECTQLLK--SCLHSVILPIGSLPIGLCVH 217 
XP_004233031 123 LSMLKQLTLTLVKGLSSTpavVVKKIAGLVCDFYKHPKYK--STHVSGTLEEVSHALG-----SQGIHMLCQIKDGSCHS 195 
Q94AB2       123 LFRQKQLITKLVSGLNSKpatIIKKIAGLVADVYKQSTLQ---SPAK-----STQSFE-----NCGIQLLGQIKHGSCRP 189  thale cress
EFH58123     178 LVMIMEFFIKSVKGKDSKe--VIKKTAVMVADVYRIKTPL--QSPAR-----TVRSFQ-----IHGFPLLGKIKHGSCRA 243 
NP_001324376 191 LVLIKEFVIKLVTGLDSDk--VIKKIAGLVANIYKRKTLQ---SPAR-----TLQYFD-----VQGFTLLGQIKHGSCRA 255  thale cress
NP_180658    115 LAMLKQLITTLVSGSGTNpalVIKKIAGTVSDFYKRPTLE---SPSKLALEENAFLFE-----NHGAQLLGQIKRGCCRA 186  thale cress

NP_194179    429 RAILFKKLADYIGLPCRIAR------GCRYC-KESHQSSCLVKIdddrKLSREYVVDLIGEPGNVH 487 
XP_001420846 186 RAILFKTLAASAGVPCRLVR------GEYYC-GRNSARVIFAE------EGSDMWVDLMLCPGTLK 238 
EFJ07496     192 RALLYKFLADSIGLPCRIAR------GCKYC-GLDKGASCLVLC----GTEREYFVDLIGSPGELH 246 
XP_002530885 225 RALLFKVLADSINLPCRIAK------GCKHC-RRDVAASCLVQV----GSEREYLVDLFGKPGTLS 279 
XP_014623204 218 RALLFKVLADLINLPCRIAK------GCKYC-RKDVGASCIVQF----GSDREYMIDLVGRPGATC 272 
XP_004233031 196 RAILFKVLADTVGLECKLIVgfp-rgGALECaDSSKHIYVTVIL-----DSIELLVDLMHCPGKLF 255 
Q94AB2       190 RAILFKVLADTVGLQSRLVVglp-sdGAAESvDSYSHISVTVLL-----NSVEMLVDLMRFPGQLI 249  thale cress
EFH58123     244 RAILFKVLADAVGLESKLVVgfpsdlRSSASvDSCNHMSVVVEH-----NNVEMLVDLKRCPGQLT 304 
NP_001324376 256 RAILFKVLADAVGLDSKLVMgfptdlRFSASiDSYNHISAVVEL-----NNVEMLVDLKRCPGQLK 316  thale cress
NP_180658    187 RAILFKVLADTVGLESRLVVglp-sdGTVNCmDSNKHMSVIVVL-----NSVELLVDLIRFPGQLV 246  thale cress
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