Conserved Protein Domain Family
DUF4403
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pfam14356: DUF4403 
Domain of unknown function (DUF4403)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 455 and 518 amino acids in length. There is a single completely conserved residue W that may be functionally important.
Links
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Statistics
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PSSM-Id: 494199
Aligned: 48 rows
Threshold Bit Score: 274.938
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012562387    48 RRSEFITPIVVPLTVIASTLERAAPRDFGgkADNPa-sQlltdsdiDWH-VSR-GTMTATGA--QNALNVSTPLAGKLIV 122 Afipia carbox...
WP_012682860    51 ALAVIPVRVPYVLSALRPSLDSLFPERDSlsEARC---AnaaglvcHQY-VYRrEGLTLNAV--DSRLQIDTRLTYRARV 124 Gemmatimonas ...
WP_025412035    46 EPAVIALPVTIVTSAVQTHLERTLPRADSldQARC---QslggavcHQY-VFRrDTLALHVA--GDRIDVLARLRYRGRV 119 Gemmatirosa k...
WP_025409177    73 DPSLVEVPIRYELGPAIGALERAVPRTVGnlDDRR---KvpghdrlSYAfVAErTPFDVSVR--GSTVTVSSVVTYHAR- 146 Gemmatirosa k...
BAH39140        43 dASVVDAPVRYALEPLITELEKAVPRTFGdrDKRIp--AgsdrkliAFE-ATR-TPFTVGVE--NGKVVLEAVVSYQAR- 115
jgi:Deipr_0487  53 PLSSLSLPVAVPLSGIREAVNARIPREFArvQQDQrvlGgragihiRGA-VVRaGDIRIVPSdsADTLELEVPLSARFSV 131
WP_013556282    28 TPSTVTLPIRVPLAGLARALDARAPQVIAdiDQPGplg-----ltlTGQ-IARaGALTITRD--ADALRVTLPVTARVRA 99  Deinococcus m...
Q1J1R6          21 ALSSITLPITVPLAGAQQAANARVPSEFArlDETRtflGgllsvklTGT-VTRaGQVSVRPSprGDGLIVSVPIRADFRA 99  Deinococcus g...
WP_012692198    20 AVSTLNVPVSVPLSGVQQAANARVPAEFArvDETRsflGglvsvalRGT-VTRtGHVSVSPSadGQSLLIRVPIRAAFRA 98  Deinococcus d...
Q9RR95          37 AASTLTVPVHVPLAGVQQAANAQVPQEFArvDQTQsllGgavqvrvRGT-VTRtAQVSVKAD--GDALVLSVPIRAEFRA 113 Deinococcus r...

WP_012562387   123 TGsLSTASG-TPLNNalGNLLGAKAaqqlgnisiks-lnanaaingtaTATARPRLTTDWHLDPQLSaqVTLA---NNSL 197 Afipia carbox...
WP_012682860   125 GTfGSARVAgcgyape-------------------------pmrradlQMTTALFWRRDWRIGARDTr-LAATlrdPCLV 178 Gemmatimonas ...
WP_025412035   120 SLpTGGSVGscgyppe-------------------------pmpraelRFTTSLYWTTAWRLASRNTs-LTSSlpdPCRV 173 Gemmatirosa k...
WP_025409177   147 ----------GWLKPpiGPSLGGSCgiggda------------prlrvTLTSTVKLAPDWTLRAHTQv-PTVApasDEPR 203 Gemmatirosa k...
BAH39140       116 ----------AWYRPfiGPTLSAGCgepkdtnkdgkagtnegrprvkvVLHSDVSLTPEWKLAARTRv-VSVKpltTTER 184
jgi:Deipr_0487 132 RPeLSGASWaGRLEStlTRDFGGEAt---------------------vRLKVKPYIQPDWEAGAQVS--GELRwtdPLAV 188
WP_013556282   100 SL-----------GGaaQQDFAGAAs---------------------vTVRVTPYLHEDWTAGVRAS--ADYTwtdPLAF 145 Deinococcus m...
Q1J1R6         100 EP--------GGLGAflARDFGGTAt---------------------vSLHVTPFVTPEWEAGAQVK--GDATwtdPLSV 148 Deinococcus g...
WP_012692198    99 EP--------GGAGSvlARDFGGEAt---------------------vSLTVTPFVQPDWEAGVKVS--GDYAwtdPLSV 147 Deinococcus d...
Q9RR95         114 EP--------GGALAslARNFGGAAt---------------------iTLRLTPYVTPTWEVGVRAS--AEHRwtdPLAV 162 Deinococcus r...

WP_012562387   198 SVA---GAKVAVPAQVKPVIDRTVneqvdrlQQRLRADDSFRRAMREQWASICRSIPLPSpasGapPLYLEMRPVKALAA 274 Afipia carbox...
WP_012682860   179 TSL-----GVNATKTLQNVVDKQLaafaaqaDSAIPVAGDFKPLADSLWRSFLEPTSLDSl----gALWLMLDPQAVRVT 249 Gemmatimonas ...
WP_025412035   174 TLL-----GIDATPIMRRIADAQLarvaqevDSALPTLADLRRPADSLWRAMQEPMPLDSt----gSLWLLMNPERVGLA 244 Gemmatirosa k...
WP_025409177   204 DKCkmtVLNVDLTDRVVDAVQKLLdgkaallDERIAK-LDLKSRVEKWWAQLARPIKVGG------NMWLQLRPEAVSVG 276 Gemmatirosa k...
BAH39140       185 DICrvtFAGIDVTDHVVKAVMPQInsrmprvDRKMAT-IDVRTRVTKWFTAMQRNIRVTD------SLWLQLKPELIRLG 257
jgi:Deipr_0487 189 ELVp--GTRLSVAALAESAVRAQLtrvtqevARAVRESAALRSRAEQLWGQVGQPWPLPLegsGvgPAYAQVMPQSLTVA 266
WP_013556282   146 EVL---GARISVASLVDAQVRTQLarvtaqlEQEVARQADARARVGALWAKLAQPWRLPTp----ePAFARVKPLSLSAT 218 Deinococcus m...
Q1J1R6         149 ELAq--GVRISVQALVEGQVRAQLdrvaadvARAIREGAQLRTRAETLWARAQQPWILPTp----ePAYARVTPQSLTVS 222 Deinococcus g...
WP_012692198   148 DLGg--GVRVSVQSLVDTQVRAQLdrvtaevERAVREGAGLKGRAGTLWARAQQPWTLPTp----eSAYALVQPRTLSVT 221 Deinococcus d...
Q9RR95         163 DLGr--GLKLSVQSLVDPQVRAQLdkltaqiEQQVREGADLRRRAGTLWARAQRPWPLPTp----ePAYALVRPLGLGVT 236 Deinococcus r...

WP_012562387   275 QPQIDNAAVTLTVG----LQAETRIVNHAtTPRCP---FPEvLDIQsalGG-----GRINVGVPIDLPFAQLGQIAEAEL 342 Afipia carbox...
WP_012682860   250 PFVGAGRNITTTLV----LYARPRVVAGS-KPRVAmrpLPA--------LAlgegsADFRVPVSVELPYGEMQRRATQLL 316 Gemmatimonas ...
WP_025412035   245 ALDGQGTTIRTGLT----LVARPRVVTGA-RPDITvrpLPS--------LAlaplaRGLRVPVQVEMPFAAVSRRATELL 311 Gemmatirosa k...
WP_025409177   277 SLRAGDGAVIAPVA----LAARPRLLSGP-RPESStvaLPNfTPSG---PKaaergSSLHLLLEAVLDYDQATRMLGRQL 348 Gemmatirosa k...
BAH39140       258 KLSIEDSMLVADVR----LWAHPRMITGP-EPQQMivpLPR-LT-----PAlsqigDSARLFIEGLLDYADASALMQKQL 326
jgi:Deipr_0487 267 GLGLRDDALHLTLQaegyLRAELGQPPLV-RPASAp--LPA-LQTS---PQpa--pGELHLRVPILLPFAELSSLATAAA 337
WP_013556282   219 PFTFTDDAARVTVSatfgAEAQLGTPPTTvTPTP----LPS-LKLA---AAp---rPGVHLTVPVRLPYANLSDAMTRAI 287 Deinococcus m...
Q1J1R6         223 SFRFTPEALKLTVGatfdLTAGLGHAPAV-PPTP----LPL-LKVA---PPp---tPGVELRVPVRLPYPALSQAATRMA 290 Deinococcus g...
WP_012692198   222 PFRFTPDALKLTLGaafdLKAGLGRAPAI-PPRP----LPP-LNVA---VAl---pDRVDLSVPVRLPYPELSAAATKYA 289 Deinococcus d...
Q9RR95         237 PPRLTPDALKLDVGatldLGAALGQPPATvKVSP----LPP-LKVG---PLs---aPGIELSVPLRLPYPELSALAARYA 305 Deinococcus r...

WP_012562387   343 KDRVFPEDg---sGAIEARIKSVDVDASGD-RLLVSLLVHATETtswfglgadAVVRIWCKPVLDANAQVLRLTDLSVAV 418 Afipia carbox...
WP_012682860   317 KDET---------ARQSVKVDSVLLRGAGD-SLFVDLGVSGALN---------GRLTLVSRPTWDAAARELRLDDLDWTL 377 Gemmatimonas ...
WP_025412035   312 AAET---------AREPLKVTRVDVAGAGD-SAVVRLALAGRMN---------ASLTLAGRPRFDVGTRTLVVDDLHYSV 372 Gemmatirosa k...
WP_025409177   349 VGRTFTR------SGHTVTVREARVFGARGgRVGLALRLAGDVD---------ARLVLAGRPVYDHASGTLHVPDLDYAV 413 Gemmatirosa k...
BAH39140       327 GSKRFYR------FGRVVAIDSVRLYPLDDgRVVLAVQVGGGVR---------GTAYLVGTPTIDHTRRALVVADLDFDV 391
jgi:Deipr_0487 338 QRELLALRlpggtLAPRVQLDRLEVTGQPA-QQRLTLTAR--LTlsglglrqsVTADISGRPWLRPGGRTVTLENVQVAT 414
WP_013556282   288 QRREFRANg---vLSPTVRVTRVDVTPQGA-RLNAAARVN--VRlgpl--nvnATVDVSGTPKLDAQGRVLTLADVRVRT 359 Deinococcus m...
Q1J1R6         291 GERPLVLPl---pFSPTLRVISVTVTPRGT-ALNAAVTLR--ISgplg-ldlqATADVVGTPTLDPSGHLVTLRDVTVTT 363 Deinococcus g...
WP_012692198   290 ATQTFALPv---pTSPTLRITGVSVRPAGS-ALGVTVNVR--VDgplg-lrvpATVDVTGTPVLEPGGRVVTLRSVTVRT 362 Deinococcus d...
Q9RR95         306 AQQTLTLPv---pGSPVLRVTGVQVQPVGT-RLRVSVQAR--LDgplg-lslrATTDVTGTPAVSADGRTVSLRDVEVET 378 Deinococcus r...

WP_012562387   419 TSDAAfgLFGALAQRAAPYLAQALEQHA---TIDLKQLSSGVQQKLAGLIgdLQADQsGVRVKANVTDVRLGEISFDSTT 495 Afipia carbox...
WP_012682860   378 QSRGR--LSRIKATLAAPLVSRAVRRATsggRVPLGAQLDAIRSELLLKLn-GTLAP-GVVMGSSVRDVQILSVRPTATA 453 Gemmatimonas ...
WP_025412035   373 ESRDF--LSRVKATLGAPLIRHAIEQATnggRLALGPQLDSARAQLTAQMn-RPLAP-DVVVGGGVTSLRLTGLYLTNDA 448 Gemmatirosa k...
WP_025409177   414 ADASL--LVRGADQVGHDAFRDALRERA---VFPVTALVDSARARAERAMn-RELTK-GVRLGAKVETGRALGVFAASDG 486 Gemmatirosa k...
BAH39140       392 ATSDA--LVAGLAWLKKGDLLERLRASA---EFPLDDALELTRNRVEGALn-RDLTE-GVRLSGTVTTGRLIDVLVHPRW 464
jgi:Deipr_0487 415 RDEGL--SSRLLGLLADARLEEYLARSA---RFDLGPRLDGLEDSLAARLp-YSPLP-GLRLRGDVGELRLDDLRVTGQG 487
WP_013556282   360 RPDGV--TQRVVGWLADARVQAFLRESA---RVDLAPYLDRALQDVRARLp-LKPAQ-GITLAGRVDALRLTDLDVTPGG 432 Deinococcus m...
Q1J1R6         364 RRAGL--TGRVLGWLADQRAQAYLARAA---RFDLTPQLRQAQRQLQERLp-FTPAP-GVELAGTVGPLRLNELRVTPEV 436 Deinococcus g...
WP_012692198   363 RREGL--TSRVIGWLADARAQAFVSRMA---RFDLAPKLAQAQAHMQGRLp-YSPAP-GVTLSGKVGALELTGLQVRPDA 435 Deinococcus d...
Q9RR95         379 RREGL--TGKAVAWLADARAQAFVTRAA---HFDLGPLLARAQAQAQSKLp-FTPLP-GVMVGGQVGALSVQSMAVQPAA 451 Deinococcus r...

WP_012562387   496 LRVIAEANGTVHVTV 510 Afipia carboxidovorans
WP_012682860   454 IVVQAYLSGQSGVWV 468 Gemmatimonas aurantiaca
WP_025412035   449 FVVRVLLEGEAGLWa 463 Gemmatirosa kalamazoonensis
WP_025409177   487 LRVRAAAGGVLSLDI 501 Gemmatirosa kalamazoonensis
BAH39140       465 LVIRAEAAGKLALDI 479
jgi:Deipr_0487 488 LQVTAAADGALDVLV 502
WP_013556282   433 VVLTSRVDGDLDATV 447 Deinococcus maricopensis
Q1J1R6         437 LVVLATASGQVQGTV 451 Deinococcus geothermalis DSM 11300
WP_012692198   436 LVVTAAATGAVRAAL 450 Deinococcus deserti
Q9RR95         452 LVVTARAAGRLQAQV 466 Deinococcus radiodurans
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