pfam14336: GLUCM-like_C (This model is not part of the current CDD release)
D-glutamate cyclase-like, C-terminal
This entry represents the C-terminal domain of mitochondrial D-glutamate cyclase, which converts D-glutamate to 5-oxo-D-proline. This is a conserved domain also found in uncharacterised proteins from bacteria and archaea. Structural studies of the hypothetical protein TON_0340 from Thermococcus onnurineus revealed an active-site cavity harbouring a metal-binding site containing six invariant aspartate and glutamate residues that adopts an alpha/beta-structure. Biochemical and mutational analysis show that TON_0340 is a Mn+2-dependent phosphatase.
Jiyao W et al.(2023). "The conserved domain database in 2023.",