Conserved Protein Domain Family
R2K_3

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pfam14243: R2K_3 (This model is not part of the current CDD release)
ATP-grasp domain, R2K clade family 3
Family of ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is predicted to catalyze peptide ligation reactions on protein substrates in biological conflict contexts, probably between bacteriophages and their hosts.
Statistics
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PSSM-Id: 521125
Aligned: 36 rows
Threshold Bit Score: 81.3116
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_083481091  33 ATGAavh-rtRVIPFTERFD--GPPPalsgpvlcyg--ygalvaagrHLGWRPCgwdgaglgLRAVVSSLgplawnaaAT 107 Jannaschia dong...
WP_045971828  24 ELGIe----yEVVNIKPTDTeiAMKAnrkdvfvygs--vtmarlakqYKDWFPGsf-----yGGNHLYEVyahy-ygsHL 91  Flavobacterium
WP_057946907  28 DAGArvq-dvLVVPFSDELG--NEVPpldgvvipyg--atkltrlaqKRGWRGLcfdeaafrVDAWNRHRddm---lnQH 99  Lysobacter enzy...
WP_006974074  24 AQGHa----vAPIVRPPFSD--AAPEldtdeatvfygssslidsvvrDGRWRPGawal-dddYASWIERYgah--mlnVD 94  Plesiocystis pa...
WP_012606891  22 VYGDayavrlEDIPSLPKSGwmpigtve------------fcrtatvHQGIQEPd-------PLDYPEALtkw---mpYG 79  Acidithiobacillus
WP_014003161  19 MYGE-------EVQSATLEGiaDLPRsgwmpvgsv----afcraamaHQGLVEPe-------PLDYPECI--------AH 72  Acidithiobacill...
KXB93630      27 KMDIp----iIRYKAIYSVT--DNDPtdlvvgtf-----sdvsvaldKLGVQLT--------PVDYPDELmpf---vgRK 84 
2_pfamImport   1 ALHIp----vVKYKAVYSIT--DNDPmdpvigtf-----sdvkvaleKLGIKPA--------PLDYPEQLksf---igRK 58 
WP_012938477  27 ELGAe----iRFFHNPLEMR--QAEPedilvgyv-----eavqqhleEMGFSYP--------DLDYPAELeyc---lgRK 84  Acidaminococcus...
WP_013370415  27 QMGFe----iRYFENINKLT--DHNKedivvsyv-----ddvrtalhIYDIVAS--------EIDYPKELtay---lgRK 84  Paenibacillus
WP_083481091 108 FHPLSDLRRLaegl-----ttqvFVRPEAETk-VFAGRL------H--DGTSML---RWLDGLDradw--agaDDPLFAV 168 Jannaschia dong...
WP_045971828  92 LNDEIKIGKLtddlvw-qkgekkFIKPYKEAk-IFTGKVf-----EkeEWEDFIieaLAHPKLSit------kDSEIQIS 158 Flavobacterium
WP_057946907 100 VRQM-SVRECmaamqdedeesrwFVRPVQDLk-HFDGTVtvareiR--RWMSSVd--SGNYSFDg--------DTEVIVA 165 Lysobacter enzy...
WP_006974074  95 ARFL-SLEELaadaelansealrFCRPSADSk-LIAGQV------D--SGAALV---AWARRVLaledasmdpDTKLMLA 161 Plesiocystis pa...
WP_012606891  80 GHVLRRYGEM----------------PRGWTleQ-HQGI---------HGKPVVtklDESLWKP---------DTPFWTS 124 Acidithiobacillus
WP_014003161  73 FAAAGHFLET-------------YADVPEGWt-PDDHRV---------HAKPYRtklDPSLWTP---------ETPFWIA 120 Acidithiobacill...
KXB93630      85 IWQS-TLFTItshpe----ywhvFVKPVVDVk-RFRGTVl-----D--KSEDLI---KLGGGLE---------DIHVWCS 139
2_pfamImport  59 IWKS-TLFTItshpe----cwhvFVKPIEDVk-RFHGTVl-----D--KSEDLI---KLGGGLE---------DIDVWCS 113
WP_012938477  85 IWKS-TINTInshpe----qwpvFVKSIADK--EITGVLv-----R--SPKDLI---GCGNWEY---------DVPVWCS 138 Acidaminococcus...
WP_013370415  85 IWKS-KLSVIannpe----nwniFIKPVEDK--KFTGVVv-----R--SMKDLI---GCSTYGE---------DPEILCA 138 Paenibacillus
WP_083481091 169 APVrPCRTEWRVWIVDGVPIAGCRYgvd----ghaDPAPDL----PGRIAAFARRAVALH---DPLPAYVLDVGEDA-A- 235 Jannaschia dong...
WP_045971828 159 KPK-TTIKEARVWIVGGQIIDAGYYk--------fNGDFAFeasvAAEGMAFAKEMISLF---NLEEAFVMDICLTS-D- 224 Flavobacterium
WP_057946907 166 PVQ-KLHGEWRFFVVDGQVVDGSSYriagqrlanaVARPEL----------YETAQSLADgwlP-HRTCVMDVALTD-E- 231 Lysobacter enzy...
WP_006974074 162 EPV-GLSDEWRTFVVDGRVVAGSHYrsyqr-levsPDLPGE-------VVAFTEALLARG---SPAPVVVVDIARSG-S- 227 Plesiocystis pa...
WP_012606891 125 PYH-RFGPEYRFYVLHGEILGYGRYdd-------rEDDPNDp--lLLDMRAVREMIDAYQk-aGAPVGYGLDVGVSDeD- 192 Acidithiobacillus
WP_014003161 121 NWH-RFGPEYRFYIRQGEIVGCGRYdd-------rDDDPNDp--lELDMGRVLAMVNQYQk-dGAPAGYGLDVGVSD-Ed 188 Acidithiobacill...
KXB93630     140 EKV-KFLSEWRIWVLQGNIVGLSPY----------RGQWDL----FPDPGILKNAVEAYH---SAPQAYALDFGVTD-E- 199
2_pfamImport 114 VKV-QFLSEWRLWVLNGTITGLTPY----------KGRWDV----FPDPSVMEEAVHRYE---GAPSAYALDFGVTD-D- 173
WP_012938477 139 EPV-RFVTEWRCFIRYGRILDARHYr----------GTWEK----IPDPAVIKRAVRDYK---TAPAGYSLDFGVMD-T- 198 Acidaminococcus...
WP_013370415 139 DIV-NFVAEWRCFVRYGKILDIRRYk----------GNWRA----HFDYKVVENVVSQFQ---AAPKGYAVDFGLTD-K- 198 Paenibacillus
WP_083481091 236 G-LGVIELNAVNSAGFY--------A------ADI-GAIVAAL 262 Jannaschia donghaensis
WP_045971828 225 G-WKIVEINCINSSGFY--------T------NTDvKSIIKAL 252 Flavobacterium
WP_057946907 232 G-YKVIEFNTFNSSGFY--------A------HDI-EKIVAAV 258 Lysobacter enzymogenes
WP_006974074 228 G-LYVVEFNGFNSSGFY--------A------AEL-SAIVAAV 254 Plesiocystis pacifica
WP_012606891 193 GmTKLVEVNDGWALGFYkgscshrdY------LRLlETRWLEI 229 Acidithiobacillus
WP_014003161 189 GlTYLVKVIDGWALGWYrgtchprdY------LSLlEVRWQEI 225 Acidithiobacillus caldus
KXB93630     200 GkTLLVEVSDAYALSSF--------GldpvlyTKIlMTRWQEL 234
2_pfamImport 174 GrTLLVEVSDGYALASF--------GlrpdiyMNIlKTRWQEL 208
WP_012938477 199 DkTLLIEVNDGYALGSYglf--yidY------AKIlAARWAEL 233 Acidaminococcus fermentans
WP_013370415 199 GeTLLVEVNDGYSLGHYglf--sldY------AKLlSARWAEL 233 Paenibacillus
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