Conserved Protein Domain Family
Helitron_like_N

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pfam14214: Helitron_like_N (This model is not part of the current CDD release)
Helitron helicase-like domain at N-terminus
This domain is found in Helitrons, widespread eukaryotic DNA transposons that have significantly contributed to genome variability and evolution, as they perform a distinctive, replicative rolling-circle mechanism, which often mobilizes adjacent genes. Helitron transposases contain a single-stranded DNA (ssDNA)-specific HUH endonuclease domain, with structural similarity to viral replication initiator (Rep) proteins. In many instances a protein-coding gene is disrupted by their insertion.
Statistics
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PSSM-Id: 521117
Aligned: 69 rows
Threshold Bit Score: 131.663
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002910373   130 IRHLLcIreRRFQEHHSfMFTAFNIIQ--RRKVLLSIALRT----RRSSFddvastfagvSSlaVSEVLDKIvtslstns 203 
14_pfamImport    2 VQRTLkFhdRRFAQHDKyRYVVYNMSIrwQSNKRSSFFLKKd---QRKDI----------TAekLKEMFHE--------- 59  
Q2GT34         582 LYHAMwHrdGRFARHPRfRFVAFNTVMrsTVNAKSSYFVRHt---HQTQV----------DLdeLRAAFDS--------- 639  Chaetomium g...
Q2H1K1         554 LQHALkWrdGRFARHPRfRFVAFNTRMrrQISARSAFFVKRheqlNPEPV----------NIdtLKEALRN--------- 614  Chaetomium g...
XP_018257366   276 VEHAMrWhdGRFARHPTfRFVAFNTLMrsQARSRSRFFVKQhd-gRQQPL----------TReqLIQALEHS-------- 336 
Q2HH23         438 IQHAMkWedGRFAKHHSfRFIALNTLMrqQARGHSRFYVSKn---HRTPL----------TKeaLQEALADP-------- 496  Chaetomium g...
XP_002487606   576 AQHLMkYkdGRFARHPRfRFIMFNTMMrqRANAQAGFMVKRr--sNLPNC----------TVdqLRAAFEE--------- 634 
XP_002488749   308 AKHLMkFhdGRFARHPRfRYVVFITMMrqQANAKASFLVKQkt-kEGREI----------TAgdLRLAFED--------- 367 
XP_002485798   472 VKHLMkFddGRFARHPRfRYVVFNTMMrqQANKKAGFFVKQri-aGGQEV----------TAeqLRAAFEE--------- 531 
16_pfamImport    2 VQHMLrLshGRFARHPMwRYACFNITMrtQAANRSSYFFKKd---NSVRL----------TVqeFRDAINS--------- 59  
XP_002910373   204 ypvpdthAqsqalnLNKQVNVIFRDVPGSSGSRVTMRNEIRSMfATELGLPSLYVTVNPPDV-FNPLVAVLggsdidiDN 282 
14_pfamImport   60 -------NteeaqsLLNSVTRFTSSILGTRPYWREKRNELVAM-VRGLGCPALFMTLSAADLhWESLAKLMpdyevwaAG 131 
Q2GT34         640 -------NapeaqrLLNSIVKHADTLRGTRAYWTGKGHQLTAH-VYALGMPAMFMTFSPADLhWDSLARHMprydewkQG 711  Chaetomium g...
Q2H1K1         615 -------EtpdgkrLLDSIVRWTGSIRGTKAYWGVKLQELLAM-AFALKCPSAFITFSAADNhWQSLHQHMprfeewlAA 686  Chaetomium g...
XP_018257366   337 -------EdpeaqaLINSITRHAVSIRGTRPFWNKKRQDLEAY-AYNLGCPGAFITFSPADLhWRSLYQHMpqyddwlAA 408 
Q2HH23         497 -------DtpeaqaILNRISRYASVIKGTRPFWYRRRRECESF-AHCLGVPSAFITLSPADLhWQSLYRHMpeyeewkAL 568  Chaetomium g...
XP_002487606   635 -------DseesnsIVNSITRMSNTIQGTRSYWASRRSDLIAY-NQNLGASHLFFTTTPADYqWDDLQRQFpnykqwkNG 706 
XP_002488749   368 -------DapegeaLLNSITRRSGMLRGTHPFWTNRQQQLKAM-VKKFGPSHIFLTVSAADLhWADLMQHLpkferwkEA 439 
XP_002485798   532 -------DtpegeaLVNSISRRSGMLRGTRPFWTNKLQQLKAM-VHNIGPAHLFLTLSAADLhWDDLMWHMpryqewlQG 603 
16_pfamImport   60 -------DspaskaLINRIICFSSSITGTRAYWAAKRRQLDAM-VRTLGCPALFLTFSAADLhWQDLARLMprydewcAA 131 
XP_002910373   283 LpDNlvptywdlaklVSQNPVVAAKFFHIYINAFITELLawdedartdptkrrigalgYTKGLYGCVEAQGRGTLHAHFV 362 
14_pfamImport  132 SnEQkiki---asmnLKKNPDIAAFHFMDRFQRFMTEVIip---------------kfNVVDFWWRVEFQARGSPHIHMV 193 
Q2GT34         712 TeRArqhi---swqnLQDNPYIAAYHFFKRYNAFRDHVLip---------------kfGIVDYWGRFEWHARGSSHHHGL 773  Chaetomium g...
Q2H1K1         687 EeLQrmri---svanLRDNPHIAAYHFHRRLQLFTTLVMkq---------------kfNLTELWQRYEWQGRGSPHSHGL 748  Chaetomium g...
XP_018257366   409 TePErmal---srrlLRQNPHIAAFHFYRRYTLFRDIVLsk---------------kfSITDYWDRYEWQGRGSPHNHGL 470 
Q2HH23         569 DePRrmak---srrlLRENPHIAAWHFHSRNSLCRKIVLkk---------------kfNVPDFWYRYEWQGRGSSHSHGL 630  Chaetomium g...
XP_002487606   707 DaIErrvi---arenVVNNPHICAYWFWLRLKTFFKEILer---------------sfNLKDYYTRYEWQKRGSTHSHIL 768 
XP_002488749   440 MsQDriqi---ardnLRDNPHIVAQWFWIRYNTFRKEVLdk---------------rfNVIENRNRFEWQGHSSVHNHGL 501 
XP_002485798   604 TaSEriqi---srqnLRDTPHIVANWFHIRFATFRKEILdk---------------kfKVVDHWYRYEWQGRGSVHVHSL 665 
16_pfamImport  132 SdAGkari---arenLKNSPHIAASYFCRRFSCFLKEVLip---------------kfGFSDYWYRLEWQARGSPHIHGL 193 
XP_002910373   363 I 363 
14_pfamImport  194 V 194 
Q2GT34         774 Y 774  Chaetomium globosum CBS 148.51
Q2H1K1         749 Y 749  Chaetomium globosum CBS 148.51
XP_018257366   471 Y 471 
Q2HH23         631 Y 631  Chaetomium globosum CBS 148.51
XP_002487606   769 L 769 
XP_002488749   502 Y 502 
XP_002485798   666 Y 666 
16_pfamImport  194 F 194 
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