Conserved Protein Domain Family
Polysacc_lyase

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pfam14099: Polysacc_lyase (This model is not part of the current CDD release)
Polysaccharide lyase
This family includes heparin lyase I, EC:4.2.2.7. Heparin lyase I depolymerises heparin by cleaving the glycosidic linkage next to an iduronic acid moiety. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme. This family also includes glucuronan lyase, EC:4.2.2.14. The structure glucuronan lyase is a beta-jelly roll.
Statistics
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PSSM-Id: 521080
Aligned: 33 rows
Threshold Bit Score: 96.6808
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_020431580             65 AATIVTTSRSGK-YAIshKVTLDDPgyy------------saGNWRSESATAGVAagcyLNNTERRHEFSVYLKDwtIYK 131 
WP_015808645             94 ANRIELSSTFGTrENL--KQYPEEE-----------------IKELSEIGEAYINsshgNYGDVVVYDWYSRFPE----- 149  Ped...
WP_012488853             45 LSVTDQCSYDGR-FAG--RVQLTGDdmflw--------ngnkQLNRSEFHHRMPEga-tREGKDTFFAFAFYLPK--ALS 110  Cel...
Q4FMS9                   63 LRYSKDIVRDGE-YSL--RFEKRKDdcgpkknkgdckrtsekwigRSEIIMDYPKs--mGETGNQWYSWSIYIPK---ES 134  Can...
Q7UP23                   50 DNIAKIKTADGAhLGL--RIYPGQPkt--------------hGGIRAEVSLDYPF----QTEDTVRYTWKFRLPE--DFE 107  Pir...
WP_014018806             70 FKVVKDPVFDGD-YIG--KFELQYGdpmv----------tknGGPRSEVLFGE------AESSEMWYSFAIYFPSy-GWK 129  Cyc...
Q7NDH0                   78 VGTTVPPVRAGR-YAA--QFNLRKSdpd------------vsSSRRAELRLGTV-----KADSSRWYAFSVYLPV--DWE 135  Glo...
PRJNA213647:NX02_24215   69 TFVVKDTRRGGQv----rGFRTRPTdah------------vkGNFRSELRLRPN-----AVGETVWYRSRLLVPA--DWK 125 
Q2SGV1                   49 ISQKSEPSCDGD-RSM--KVELYFDqkk------------nkYNYRTELTNMQQF----QFGKEYWVSFAAFIPK--NWK 107  Hah...
WP_013034192             56 YNRVTNVSREGS-YSL--RTFQRGDqgcvq--------pngvERKRTKFVLGDVRy---SRDTTYWIGFSVYVPK--DYP 119  Nit...
XP_020431580            132 VGDps--tIDIIYQCKSTSSG---------------------------------------------------PAWFLGV- 157 
WP_015808645            150 --AespekGGIIAQIHGRPDRtllvnpkgeivrvsikvmkamldtmyfdlhigknkqtkapngwrvdaaaggPIAEMSY- 226  Ped...
WP_012488853            111 QHKh------eLGYWESDKSWq--------------------------------------------------QMFRFNI- 133  Cel...
Q4FMS9                  135 NRPknidgQIILGQFKTHNKHlsktrkyvvg--------------------------------gknkndsncTEISLTIr 182  Can...
Q7UP23                  108 SDVpq-nrWWVIGQWHDQPDRtkdetwe--------------------------------------tqpsysPPISIGIa 148  Pir...
WP_014018806            130 TDNd----DEIISQWHASNGT---------------------------------------------------PPLSLRV- 153  Cyc...
Q7NDH0                  136 TDEd---sYDIIAQWHDSPDFdlge-------------------------------------------twrsPALNLQV- 168  Glo...
PRJNA213647:NX02_24215  126 ASKv----PVIAMQWHGSKDFflle-------------------------------------------pgkyPPLDISI- 157 
Q2SGV1                  108 NDGk---yDDIIMQVHGTPDTnlge-------------------------------------------hyrnPPLALSI- 140  Hah...
WP_013034192            120 IHR-----NDGIFVYGSTSGSqp-----------------------------------------------gePAMYL--- 144  Nit...
XP_020431580            158 ---------KRNQIVLRIPDSGVQSEIIAD------------------------------VSKVVNQWIDLKVEV-YNVD 197 
WP_015808645            227 ---------RPPYLYLMARSSAERISHSETrtrpypgkvqvgkvigengktgflafseptSSVPINKWVHFKMEIkYSKY 297  Ped...
WP_012488853            134 ---------HGQSLSFQQSNQDTpfw-------------------------------tldAGAAPGQWQRVALHIhWSTN 173  Cel...
Q4FMS9                  183 lnkdglmsdRSGVTYCNSWHKDNislhkkf------------------------yqklvdIDDVRGKWHDIILHAnWTDN 238  Can...
Q7UP23                  149 ei-----enR---LAIGLSYGTTLGNHKQAvs--------------------------dpIPIQRGDWYTAQADIrWSQT 194  Pir...
WP_014018806            154 ---------KNGKLRLRVGRTEGtsvkf---------------------------tylefGDVPKDEWNEFVFHVvHSKD 197  Cyc...
Q7NDH0                  169 ---------AAGNWKINRRWDPNpvtydntpgp------------------gggtesiglGPYSKGVWTDWVLHVnWSYE 221  Glo...
PRJNA213647:NX02_24215  158 ---------RGNRWQVSKSWDHRivtvkdkalpg----------------nvegiveigeAPLVRNTWMTWVIRVhWSSN 212 
Q2SGV1                  141 ---------QDGKWVVGVLADTRkltpkpgkgvk---------------kytlskkydniGAVNKGKWTTFVMQFkASPQ 196  Hah...
WP_013034192            145 ---------RDGKWQIDNRWYDGssvkh---------------------------srifeGKADTGRWTDFVLELrRSPI 188  Nit...
XP_020431580            198 V-------LkGYIRVYSkMSnetNFtlkykIDNIKTFVPDSETSQf-----aYCKWGLYRPdse------iskGSVPTRI 259 
WP_015808645            298 ShtadevlEkGYIKMWM-DD---KV-----LCDIKDVNIGKNDELg-----pYFKYGIYKPak---------gGFTVEHS 354  Ped...
WP_012488853            174 P-------AtGFVQTWV-NGedmGKyhfptLPAKDAr--------------mFTQIGILRT------------QEKQPAE 219  Cel...
Q4FMS9                  239 D-------E-GFFKIWV-NS---EL-----KLDHKGKTLSKVMTIdgkkhgpMFRFGVYSQk------------wTGTTI 289  Can...
Q7UP23                  195 E-------N-GSIELSL------VE-----IPESATLMKGPNMNNay---qhYLKVGMYRHp-----------GIQSENW 241  Pir...
WP_014018806            198 S-------D-GLVEVWK-NG---EK-----LATHKGPNLYSDGKh------tRWKIGIYKStwg------knsTDINLRV 248  Cyc...
Q7NDH0                  222 D-------N-GVLEVWK-NG---VL-----VLAREGPNTYNDQTg------pYLKLGIYKPdwky----dpaeSTTSSRT 274  Glo...
PRJNA213647:NX02_24215  213 E-------A-GRTEIWL-DG---KK-----ITDDRGPNAHRDLIg------pYMKAGTYVPnwgy----agveKDIKERT 265 
Q2SGV1                  197 K-------D-GYLNVWV-DG---RQ-----KVKHTGGIFFNDAKg------pYFKAGLYKPgwkkganwsgqmTVGGYRL 253  Hah...
WP_013034192            189 K-------GnGVLRAWM-DG---KL-----VGETTGVIVGTDYSTp-----pVAKLGIYFGg-----------NRSDDYT 236  Nit...
XP_020431580            260 IYhdNIK 266 
WP_015808645            355 GFteTVK 361  Pedobacter heparinus
WP_012488853            220 IWidAal 226  Cellvibrio japonicus
Q4FMS9                  290 AYydSIS 296  Candidatus Pelagibacter ubique HTCC1062
Q7UP23                  242 IHidQIN 248  Pirellula sp.
WP_014018806            249 TYfdNVR 255  Cyclobacterium marinum
Q7NDH0                  275 LYidEVR 281  Gloeobacter violaceus
PRJNA213647:NX02_24215  266 LLfdDla 272 
Q2SGV1                  254 HYfdALK 260  Hahella chejuensis KCTC 2396
WP_013034192            237 LNfdSIK 243  Nitrosococcus halophilus
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