Conserved Protein Domain Family
DUF4258

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pfam14076: DUF4258 
Domain of unknown function (DUF4258)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 95 and 124 amino acids in length. Structural models show this family adopts a structure found in bacterial toxins, suggesting this family are the toxins in a toxin-antitoxin system.
Statistics
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PSSM-Id: 493947
Aligned: 93 rows
Threshold Bit Score: 36.9146
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015256717  29 ISNHYYRDRQsDRGYDEMDVLMAITTGR-IVEGYDcgqhptQRNRDPKRIIIGKDKYGEWV---------------VVPV 92  Thermobacillus ...
ESQ11272      19 VTTHAAEELD-DDGLTIYDLERVILGGQ-IVEEQKd-----RDPPETKFLVRGPTLDDDVA---------------TVVV 76 
WP_015236491  76 IKAHAQQHAR-AEGFLETDIVQVLDTG----------------------RVRAVYPEDHRWlvcgyfeahgyilplHVVV 132 Deinococcus per...
Q9RXU2       144 vcPHAVQHAR-AEGFMESDIMDVLLTG----------------------RVRAVYPEDHRWlvcgyfeahgirlplHVAV 200 Deinococcus rad...
WP_015480232  50 YSNEAKKVMQ-TSDIDSLKIEKILNFGD-VDFGKGkprqkpc-----aeyfvtGKKELENV---------------SLYI 107 Polaribacter sp...
EAP86414      30 FTSEAIAEMA-RVQLDTSDISAALLNGDvIFSESN-----------------------TNLdscniyaishykgdqEFKF 85 
WP_011963214  51 YSNVASKELA-EDWLDTIDVKNTLQYGD-VDFSRSnlkiskg----klytiiGKTIKNQPI---------------EVIV 109 Flavobacterium ...
4_pfamImport   1 YSKEASKILS-EKWIDTTDIRNTLTYGD-VDFSRSniqtksg---gkryiieGFTTKKQSI---------------ELEV 60 
WP_013871032  53 YTTEAQDFLV-NKSIDTTQINYILYKGD-INFSKSesrkkpc-----giyfveGEIDNKET---------------ALII 110 Lacinutrix sp. ...
WP_015049420  26 ISRHALQRMG-ERGIAEEDITKCGLEGK-VLETQD-------HGRDIKVLVQGVDTDGQDF---------------YMIV 81  Thermacetogeniu...
WP_015256717  93 AMKSSKEf-IVTTVFP 107 Thermobacillus composti
ESQ11272      77 KPGPTNKl-IIITVFR 91 
WP_015236491 133 ELQEHGTwfDVVTAFV 148 Deinococcus peraridilitoris
Q9RXU2       201 QHYRDGHi-DIVTAFV 215 Deinococcus radiodurans
WP_015480232 108 SRCDSTS--TIQKIMI 121 Polaribacter sp. MED152
EAP86414      86 KAENCKV-----KATI 96 
WP_011963214 110 ENYEDKV--VLKEVkk 123 Flavobacterium psychrophilum
4_pfamImport  61 ENFEDKS--VLKNII- 73 
WP_013871032 111 ENCKEKA--FIKTIkf 124 Lacinutrix sp. 5H-3-7-4
WP_015049420  82 ALRFPRP--VIVTVCR 95  Thermacetogenium phaeum
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