Conserved Protein Domain Family
UBN_AB

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pfam14075: UBN_AB 
Ubinuclein conserved middle domain
Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.
Statistics
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PSSM-Id: 493946
Aligned: 21 rows
Threshold Bit Score: 186.758
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCA73749      389 ATGSFHPELQVAIENLQAAIKKHDfaiKGK-----FPPDLKPILTDVAIQAITV-----GDYNDNFFNLLPTIFPYNRFT 458 
1_pfamImport    1 PAEELPEIIVEIIESIKTEAQKAIq--NNLn---iFSEKINLDLLSLEYQKELI-----TFNAQPVYATLAEHMLCDKEK 70  
XP_032294006  449 LPASLDNDMLASINCFKELVRSRDl-cGKRf---fFDGKLTALLLKVYEALLCTe----RNERNMVFAHLEYQLQLPKYF 520 
EDW24019      437 LPTSLDADILSTVNCFKETVKSRDm-cGKKf---tLDNNLSSLLLKVYEALLCTd----RNERNMVFSHIEYQLQLPKYY 508 
XP_002037159  436 LPTTLDADIVTAVNSFKEAVKSRDm-cGKKf---nLDVKLSPLLLRVYEAVLCTd----RNERNMVFSHIEYQLQLPKYY 507 
XP_049529371  633 LPDGIGESLRNDIGTLLELANSQSgggGKLn---yFDSKVADLMLQIDEACRSYggsgsNSTRNVVFRYLEAHLSISRQS 709 
EDS31586      441 LPDNLPDHLVQDLNSLKEIAKATS---GKVn---fLDGKVADLLLQIDVTSRMCg----GSARNSVYKHLESHLQVSRQT 510 
XP_002112579  245 LPKDLPMEIIEMVNQIVEIGGSLK---DKEnfedsRAQEILNKLASKFRYSNVC-----RKMRENVCIYLKHHLPGCKMP 316 
XP_016289596  457 PTEPVDPRLQAAFDDLKRKVDAESfqkAK------FPPSLKAPLIETAKLAVML-----TEYNENFFNHLPTIFPYNRYT 525 
XP_007334563  321 HP-----ELQASIEHLKEAIKAENwsqKGK-----FPPNLKTQLSNLALQAIKL-----DEYDEHFFSLMPVLFPYNKFT 385 
CCA73749      459 MMKLTKRlvykDHVRLVHERQNVLLEELKKLVDEGFENAESEYHRNVAMWEEKKarrkteggvgmegveh-----tgpaa 533 
1_pfamImport   71 LVKQVNQ-----LVDFEEEKITEPIERLKNAIKKILPSVIEQYNLECNKVLDQRn------------------------- 120 
XP_032294006  521 ILRKAKA----LRAREEKNKTTIALERLRKAVAEVMPKAIANYEIELHKFAELAa------------------------- 571 
EDW24019      509 ILRKGKA----LRSKEEKTRTTIALESLRRAVSESMPKAIASYEVELHHFAEQAa------------------------- 559 
XP_002037159  508 MLRKGKQ----VRAKEEKRKSTIMLEKLRRAVAVVMPKAVANYETELRTFAEQAa------------------------- 558 
XP_049529371  710 LQLKLKK----IRIRWLENRSKSTLGKLENAVNQMMPAILAKYELDCAKVQEIRaaqqaqaaataaaaaaasstannssi 785 
EDS31586      511 LMIKIKK----IRIRKEDNKVKKALDKLETVVKEMMPKLVASFEAEKKKAADLRtaqaa--------------------- 565 
XP_002112579  317 VRSVIIK----MMLNEVKDDLNARMNELKEEIDKCMESQQKNYDKMTGDNKENSddsdm--------------------- 371 
XP_016289596  526 MTKLVKReffpVHMKFFDELKQEHLDKLGGMIRDSYPQQLADFEAAHKAWMERGeapkegeapqa--------------i 591 
XP_007334563  386 MTKLIKRtvfaDHTKLLHDRQEELLKELKALTDEGFQKAEEEWEKSVLAWDRRQekakhdqtdsaaptrhpt-eemevdg 464 
CCA73749      534 ptqapvaapdIDHEGDDEGDDDKDKAPGQRYRLNEAMRGYLWALVQLSNEVCTLTNdknfleGSKeVVSEQSQRK---EL 610 
1_pfamImport  121 ---------vNGTSNDGLKSKPGPKRPRRKFPWNEEFRTLVREIINIRKTTYSKIK-------RS-HSIDMFIQQ---FV 180 
XP_032294006  572 ---------------ADVNAEHPPKMPRKKFQWTNELRERLYEVYQARWTSYAVLG------KRK-DSLEQFING---YL 626 
EDW24019      560 ---------------ADVNSEVPPKMPRKKFQWTSELRNLLFTVYQARWTSYAVLG------KRK-DSLEDFING---YM 614 
XP_002037159  559 ---------------AEVNSELPPKMPRKKFQWTSELRHLLYDVYQARWTSYAFLA------KRK-DSLEEFINW---YL 613 
XP_049529371  786 satslmtngaEKPDAAPVSV-PQVRNPKKRFPWNDRSSVLLWELFTLRSDMYGLVR------PRN-ESQEEFVAD---YL 854 
EDS31586      566 ------aaasAGTDGTSAEKQPDVKSPKRKFPWNDTLRGLLADIAQIRKQSFHILR------PRK-ETEEEYVQS---YL 629 
XP_002112579  372 -----ndhteKEKSKEDQEKQDKKRLPRKSFQWNETLRQLLEKIVILKEEFTKLSS------NRV-SLSDNWLTElklFF 439 
XP_016289596  592 kppkaangddAMDVDGPQDGEDENVEPTKRWKWTEEMREEVFTLITIENAMSELRNekhkleNSTeQYSEINARK---AC 668 
XP_007334563  465 astvagqqpdAESKDGGGKESKEGQRPQKRYRLTEPMKNIVWQLVLLSNECCRLENekngleGSViQVSEQGLRK---NL 541 
CCA73749      611 YKKVLQAFP-DGWMN-TGTISR 630 
1_pfamImport  181 NNQIKPLWP-VGWMK-SANIVK 200 
XP_032294006  627 KDKIVDVWA-TGWMR-YEELQR 646 
EDW24019      615 KEKVVELWP-MGWMR-YDELQR 634 
XP_002037159  614 KEKVVELWP-PGWMR-LDELQR 633 
XP_049529371  855 RTRVVPLWP-KGWIR-YEDLQK 874 
EDS31586      630 KKSVVPLWP-SGWMR-FEDLQK 649 
XP_002112579  440 DKEVKTLWP-KGWMNkRSKIGQ 460 
XP_016289596  669 YKQMAELFPeDGWTT-STNISR 689 
XP_007334563  542 YQKIVPQFP-DGWMN-SGHISR 561 
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