Conserved Protein Domain Family
Cep57_CLD
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pfam14073: Cep57_CLD (This model is not part of the current CDD release)
Centrosome localisation domain of Cep57
The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.
Links
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Statistics
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PSSM-Id: 521072
Aligned: 25 rows
Threshold Bit Score: 153.173
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_031820309   50 ALLLALKTLQDKIYQLELERTQAEDNL--NTLSQEAALYKKALQNE-NNERDLAHQELIKQR---KDISAQLSAAQTRCS 123
Q6P2R3         54 ALILALKTLQEKIHRLELERTQAEDNL--NILSREAAQYKKALENE-TNERNLAHQELIKQK---KDISIQLSSAQSRCT 127 human
XP_069034717   69 AVIAALKTLQAKIKRLELERAQAESSM--RQLSEKAQWYRGEPEQ--PKTSNLNVQKGATQD---TELVAQLRSAESRCC 141
XP_007255729   68 AVLAALKTLQEKMRRLELERKHAQRNV--EQFSQAARQYASCTAQ--TELQLGAKEKDSSQR---KELVSQLNSAEARCS 140
12_pfamImport   1 AFVNALKNLQQKIDQMELEKKQAKAKN--QQLSHRVTNHQPVSSPY-VEAALPTAGQPGPDGwnqEEYTLKLQSVEAQCK 77 
XP_011615953   57 AVVNALKNLQRKIRQMELEKKETETNY--QRLSHDVTHHKEGSSSR-SVAHQPGPTGSAR-----EEYLSKLQSVEARCK 128
XP_040017335   59 AVVDALKTLQEKIRRLELERKQAQKSY--GQFSQDAWRRPEVTGSL-AVHSQAVAGQPATGNsgkKELDSKMQSAETRCK 135
XP_005802703   63 AVVDALRTLQEKIRRLELERRQAERSY--TQFFQDARKRQ-------QDFTSQSRTEATLPG---TAVDQKLQSAEARCK 130
6_pfamImport    1 AILSALRNLQEKIRRLELDKGEGVLQVgeNDISHRVLPSERVSQSLlNDQIDTARREDSHSRs-nQALITHLAAAESRCA 79 
XP_014326150   79 AILSALRNLQEKIRRLEFEKEQAELSL--CTLLKDGRLQSDSPAQRlLTDEDIERKASEQSNc-nQVLITHLAAAENRCE 155

XP_031820309  124 ILEKQLELAKKMVFNAEQEKIFALEQ--QQLQWEKGQDQM-----KLNAKLEKLEVLEKECVRLTTTQKTAEEKIKHLEQ 196
Q6P2R3        128 LLEKQLEYTKRMVLNVEREKNMILEQq-AQLQREKEQDQM-----KLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEE 201 human
XP_069034717  142 LLEKQLDYMRKMVENAERDKNAILEKq-VSLQKEKLKDQE-----QVHGKLEKLEMLEQECLRLTSTQSMAEKKIQQLEH 215
XP_007255729  141 LLEKQLDYMRRMVESAEREKIATVNKeeRGHQNERSQPDL-----RFRDQLKKLERLENECLKLSNTQSEAERKIELLER 215
12_pfamImport  78 ILEKQFNYMRKMVEIGNKERKAVAEKq-SLLPNLQPSSS------DVKSQGKKLERLEIEYSKLSRTQALADTKLAILEE 150
XP_011615953  129 ILEKQLNRMSKMVENGNKERKAVIEQq-SLLQNQQPSSS------EIRTQHEKLEKLETECFNLSRTQALAETKLASLEE 201
XP_040017335  136 VLEKQLDYMRKMVESAKKERNVLMENq-ASLQNQQPCSS------NTQCQRDKLEKLESECLKLSQTQTLAETKLAILEQ 208
XP_005802703  131 VLEKQLEYMKKMVANVKKERNVLMENe-ASLQKQQLSSP------NNQYQQEKLEKLESQYLKLSKTQTLAEMKLSILEQ 203
6_pfamImport   80 KLERQLEYMRRMLRSDRAHGTRLHSQ---EFTKNPNAA-------NKPAGMEKLEKLEEEYLRLRCAQQNAETKILELEE 149
XP_014326150  156 KLEGQLEQMKRMLPRTESTSLPNQEVnsEALTEKPGTGSQqpdglSEHAQLEKLEKLEQEYLRLTCTQKNAEMKICALER 235

XP_031820309  197 KLTEEEHHRKLIQDSAAQLQTGLEINRILI 226
Q6P2R3        202 KLKEEEHQRKLFQDKASELQTGLEISKIIM 231 human
XP_069034717  216 KLLEEEHQRKLIQEKAAQLQTGLEMNRILH 245
XP_007255729  216 KLLEEEHERKLVQEKAEELQRELAANLVSL 245
12_pfamImport 151 KLQKETCQRLLVQEKAERLQRELDTSLRSP 180
XP_011615953  202 KLLREERERLLVQEKADQLQKELDTNLQAS 231
XP_040017335  209 KLLKEEHERKIVQEKADQLQRELEINFQLS 238
XP_005802703  204 KLLNEEHERKLVQEKADELQRELDVNLRLS 233
6_pfamImport  150 KVQEEEHQRKLMQDRAKLIQRGMEANRILL 179
XP_014326150  236 KINEEEHQRRLILDKANQLQTGMEANRMLL 265
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