6NQ3


Conserved Protein Domain Family
Mtf2_C
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pfam14061: Mtf2_C (This model is not part of the current CDD release)
Polycomb-like MTF2 factor 2
Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.
Links
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Statistics
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PSSM-Id: 521066
Aligned: 7 rows
Threshold Bit Score: 86.3338
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6NQ3_C         35 SLSHLKSSITNYFGAA-GRLACGEKYQVLARR-VTPEGK---VQYLVEWEGTT 82   human
EEZ97202      669 NMDDLKSSVNIYFGAA-NRIAAGERFAVKAKR-VGPSGK---LEFLIEWEGPG 716 
XP_002016386  986 SILDLKKSVNKYFGGAmNRIDSGEPFAIRAKR-RTGNGQ---VQYLVEWGGDA 1034
XP_002062814 1106 SMLDLKQSVNKYFGGAiNRIDAGESFAIRAKR-RMGNGQ---VQYLVEWTNGN 1154
XP_018670183  648 AHEDLRKNIARYFGPE-GRIACGERYRVLAKRqVSMKGNpphTEYLIEWEGYT 699  vase tunicate
XP_046800194  445 QLNHLKNSITSYFGAA-GRIACGEKYRVLARR-VTLDGK---VQYLVEWEGAT 492  chicken
XP_011617916  512 DSSHLHSSISSYFGIA-GRLTNGERYQVLARR-ITPQGT---VQYLLEWEGAT 559  torafugu
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