Conserved Protein Domain Family
Nudc_N
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pfam14050: Nudc_N (This model is not part of the current CDD release)
N-terminal conserved domain of Nudc.
The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.
Links
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Statistics
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PSSM-Id: 521060
Aligned: 27 rows
Threshold Bit Score: 67.2045
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003385492  15 TYDSVLLSILK-SCGKIQPFFECIFSFLSRRTDFYIIMEQEH-------A--------------------EM----GFPQ 62 
ESS34367      14 VHEELLLNLAR-HHPDIESLLQTFFDFLERRTDFFHVIESSGasaglesP--------------------NM----GFRE 68 
Q8IAW7         5 KHENMLMAIAR-DFNSVDDLIETFLTFLENKTDYFHVMLNDK-------DvetlsekydgailknllnnnNC----GFKA 72  Plasmodium falc...
Q4UCB0         4 NFDEFMFMALK-ECKGIEDVLEKFFSFLRRRTDFCHTVLTPEqlkefglD--------------------DSvnsrGFRP 62  Theileria annulata
A0BGR6         4 RFDEHFFLIAK-ETGGIEGLLNSLFSFLLRRTDYYYECDPGD----------------------------KM----GFPP 50  Paramecium tetr...
XP_012653001   6 RFDDYYFTICK-ETGGIEGVLHSMFNFLFRRTDFFYEADPGD----------------------------KM----GFIP 52 
XP_002908770   4 RFDALLAQMAQ-QHGGVEPLLESFFGFLHRKTDFYVVSSDPAk--------------------------aKM----GFLP 52 
Q4UH66         7 GVDNLLLLLTQ-RSGGVEKLLENFFSFLARKTDFY-----------------------------------------RPPD 44  Theileria annulata
CBN79652       7 KFDDVLRNLAG-QAGSLEALLGAFFSFLHRNTDFYVTFDPTKta------------------------raGM----GFPA 57 
XP_002286618  22 HFEAPLIALANlSGGDLRKLFYAFFSFLNRRTDFYCILPDDG-------Sgas---------------grNM----GFKE 75 

XP_003385492  63 GMALNMVIQAFK 74 
ESS34367      69 GRAEAMVRQAFS 80 
Q8IAW7        73 HSREQLLIKSFR 84  Plasmodium falciparum 3D7
Q4UCB0        63 NQMRDLVNKIIE 74  Theileria annulata
A0BGR6        51 GVALNMLGNIFK 62  Paramecium tetraurelia
XP_012653001  53 GQSKQLVNKIFD 64 
XP_002908770  53 GQAQQKVLAAFQ 64 
Q4UH66        45 KTSESSLDHCVN 56  Theileria annulata
CBN79652      58 GKAEKLLLRAFR 69 
XP_002286618  76 GQAEQILIASFR 87
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