Conserved Protein Domain Family
MBD_C
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pfam14048: MBD_C (This model is not part of the current CDD release)
C-terminal domain of methyl-CpG binding protein 2 and 3
CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 and MBD3, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.
Links
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Statistics
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PSSM-Id: 521058
Aligned: 39 rows
Threshold Bit Score: 87.2968
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015782691 148 DQEF-YESFDLPKSMKPVGPNVGPETALRSVATAL-HLHIKPITGQTAGRTVLEKNPGAYLDTKQPLIGAVIITDDEIKR 225
ELK12830      81 EGEP-LSALDITNVIKMIAPGSACESRDGAGAGSL-HTSPGPTA--ARSSGWAELIPAADLSLRQFLCGQPV-TPGDIRR 155
XP_006156214  78 AGEL-LSTLDLAKILQTFAPSSTGVSMPGPLTGGL-HSSPTSPL--AQSSDLAEMIPGAGLDNSQ-LCKQLLVTEEEIRK 152
9_pfamImport   1 SGEL-LSTLDLAKSLQKLAPGCTGASLPGALAGGL-CSSSMPSF--AQSSDLAQITPRVGLSISQILCKQFLVTEEDIRK 76 
XP_003953395  80 AGEL-LSTLDLANTLQKLVPSYTGGSLLEDLASGLeHSCPMPHL--ACSSDAVEIIPGEGVGISQLLCKQFLVTEEDIRK 156
5_pfamImport   1 AGEL-LSPLDLAKALHNLTPSCTGASLPGVLTGGL-NSSPMPTP--SGSSDFAEMIPGAGMGVPQLLCKQFLVTEEDIRK 76 
Q2KIS0        80 AGEL-LSPLDLAKALQKFAPSCPGESLPGVHTGGP-NSSPMATP--AWSSDLSQTVPGAGSGTPQVLCEQCLVTEEDIRN 155 cattle
XP_027298407  80 VGEL-LSTSDLAKALQDLTPRGTDSSVSETQANSI-DFRPMPTH--ESSSNLVEMIPEAGM--PQILCNQFLVTEEDIRN 153
XP_002761706 102 QGEGsSSPLDLDSILSVLAPGMAGESLDRAGAELT-HSQPEPTPGQL--PAGAGAPPGVGCQLPPPFSGQLV-THADIQR 177
8_pfamImport   1 EGAI-LSPMDFANTLKIIAPGIPEECLSGAGGGGM-HSHPSPIP--VPSASSVKRSPGVGAHLSLPPYNQPV-TTADIQR 75 

XP_015782691 226 QEERVNNIRRKVAIAV 241
ELK12830     156 QTWKVKKARERLAMAL 171
XP_006156214 153 QESKVNAVREKLAIVL 168
9_pfamImport  77 QERKVKAVRERLAIAL 92 
XP_003953395 157 QEGKVKTVRERLAIAL 172
5_pfamImport  77 QEGKVKMARERLAMAL 92 
Q2KIS0       156 QERRVKTARERLAIAM 171 cattle
XP_027298407 154 QERKVKKARERLAGAL 169
XP_002761706 178 QARKVKKARERLAKAL 193
8_pfamImport  76 QARKVKKARQRLAKAL 91
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