Conserved Protein Domain Family
Questin_oxidase

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pfam14027: Questin_oxidase (This model is not part of the current CDD release)
Questin oxidase-like
This family consists of oxidoreductases involved in the synthesis of different polyketides and derivatives. Questin oxidase GedK from Aspergillus terreus catalyzes the ring cleavage of the anthraquinone questin to form benzophenone desmethylsulochrin. It is part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products. MdpL from Emericella nidulans is part of the gene cluster that mediates the biosynthesis of monodictyphenone.
Statistics
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PSSM-Id: 521046
Aligned: 194 rows
Threshold Bit Score: 117.756
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KDE09872     122 FHNHAAHHLLASYSLGAPASLLKNIWE-VH-L----IEgtKPMLPlhpigltEA-NWTKHLGNEKFYPNYLAFFMRQIK- 193
XP_011121851  97 FHNHLPYALASAYIFGASKEHLHDIYEaESkEleqwQD--SPEEId------PD-NWRAHLGDKRYQRAYLNFFEDEME- 166
XP_054125050  62 SHNFIPQHLISAFLFGADGQTLESLYDlDSrIaeawKD--APGEVv------GS-DWMDFLGKKEYERAFLDLFEDDLV- 131
XP_002487961  64 SHNFLPQHLVSAFLFGADNYALDNLYEaNSgLlepwKD--APGEVv------GS-DWMDFLGKREYERAFLDLFEDSLV- 133
XP_002563152  63 FPNQLIHLLSSSFLQGADADTLGRIYEkEVsDlvkwKE--SPAEIt------IL-DWRGHLGCRKFDRAFVDFFEDEMV- 132
XP_050468487  59 FHNHAPHSLCSFYLLGANADDLNRLYEaELkPleawID--SPGEIs------TY-DWRDYLGKREYQRAYVDFFEDELV- 128
Q0CX98        63 FHNHVPHILGSSFLQGADANDLTRAYEaESkGleawVD--SPNEIs------TY-DWRDYLSAKEYQRAYVDFFEDELV- 132 Aspergillus ter...
XP_003015459  68 FFNHIPHLLSTAYLLGGSSDHLDRLYEaESkEqepwSA--SPSEIg------QAeDWRLALGKREFQRAYVDFFEDELSr 139
XP_002843782  50 qllklNHLLSTAYLFGGSPDHLDRLYDlESkElepwSD--SPGEIg------QVeDWRSALGKRESQRAYLDFFEDELTq 121
XP_001248575  65 FYNHMPHLLSTAYLLGGDSEHLNRLYEsESkEleqwVD--SPGEIg------DI-DWREFLGKREYQRAYLDFFEDEVVr 135 Coccidioides im...
KDE09872     194 E--I--PlatsqyaerkssviPVLERYLL--G---GQGQ-----MLVRAVSGALHGLINIGYGVEFGLDALVAEGLAQSA 259
XP_011121851 167 QrgHdwK--------------ATLWHFLTdkQvddGAEEwdnhqLLYGLTEGIGHPLIHLGYALELEDKGIAMEALAMAA 232
XP_054125050 132 DqgYdwK--------------AVLQKFLF--T---GEQP-----LISSITAGLGQPLIHLALSLQMSVRDLAMEALTLAA 187
XP_002487961 134 EegYdwK--------------VVLQKYLF--S---AKQP-----LISSITAGLGRPLIHLALALQMSIKDIAMEALTLVA 189
XP_002563152 133 RlsYdwK--------------EVVAEYLF--T---DKEP-----MFDSIMASLGLPLIHLAYAFEMDSREIGMEALALAA 188
XP_050468487 129 RhgYdwK--------------TVVFQYLF--S---GKEP-----LFNALASDLGHPLIHLAYAFEVSSREVAMEALSLAT 184
Q0CX98       133 RhgYdwK--------------EVVQNYLY--S---GRQP-----LVNSLVAGLGHPLIHLGYAFELSSRETAIEALALTA 188 Aspergillus ter...
XP_003015459 140 Mg-YdwN--------------AVVLQYLC--S---EEKP-----LINSLIAGFGHPLIHLGYAFEVSSREVAMESLAMVS 194
XP_002843782 122 Lg-YdwN--------------AVVTKYLF--S---DDKP-----LINSLISGFGHPLIHLGYAFEMSSREIAMESLAMIS 176
XP_001248575 136 Cg-YdwK--------------KVAQEYLC--A---DKMP-----LVNSLISGFGHPLIHLGYAYEMDNREVAMEALAMAA 190 Coccidioides im...
KDE09872     260 VTS---------PQvSplfdaawpppprtqtamqftlssalssfklgsgsfgtmpiaspsdsfvqtaarlPr-eRrvprE 329
XP_011121851 233 GSYkkvh--elvDDpY------------------------------------------------------Pp--Lpf-iS 253
XP_054125050 188 TSYydndvfkysDEpS------------------------------------------------------Yf--QaeplY 211
XP_002487961 190 TAYydndilkysDDpS------------------------------------------------------Yf--QaepiY 213
XP_002563152 189 TCHndiy--kslGGpK------------------------------------------------------Hs--EnkesY 210
XP_050468487 185 VCYgtah--kylDDpS------------------------------------------------------Ys--QaessY 206
Q0CX98       189 TCYsdih--kyfDDpS------------------------------------------------------Ys--QahssY 210 Aspergillus ter...
XP_003015459 195 CCYddvh--klfDEpS------------------------------------------------------DlqkSmapkY 218
XP_002843782 177 CCYddvh--kffDDqS------------------------------------------------------DiqiNmtprY 200
XP_001248575 191 SCYgdih--kylDNpS------------------------------------------------------Yl--RsassY 212 Coccidioides im...
KDE09872     330 GL-AGFTILERiLHDARLAPDv-------aVfekdfpklgnllkrrADIIIEWCDEWKFscdaspdygeehqakrkegtp 401
XP_011121851 254 TA-DIREILDKlFDNRDYDDIcskn-gmgdPeki----------idDPPYFA-FYTYVIek------------------- 301
XP_054125050 212 KScSISEILHKvRTDERFNSYtitipgeqnMavif--------cdheAALLDHCNAWTIss------------------- 264
XP_002487961 214 KTpSVPEILGKvRTDERFTNEalitpgehnMaiif--------rdheAALLDHCNAWMFps------------------- 266
XP_002563152 211 ESkSLFAILDLvRKDEDLDGLfptp-gsdnLdtlf--------vsrnAALLNHWKAWKIe-------------------- 261
XP_050468487 207 HStSPFEILQKvRADKRLSNLftap-gdhnTeivf--------rdaeATILDHWNAWKItsn------------------ 259
Q0CX98       211 SStSLFEILSKvRADKRFHGLfgtp-gdhnLdvlf--------tkheADLLHHWNAWKIe-------------------- 261 Aspergillus ter...
XP_003015459 219 TTsSPFEVLNKiHRDKQFDGIfrsp-gannVevll--------kthqELILEHWMAWvp--------------------- 268
XP_002843782 201 TTnSPFEVIQKiHGDRRFDGMfatp-ggdnVevlf--------ktqqTLILEHWMAWdp--------------------- 250
XP_001248575 213 KTtSLLEIINRvQNDKAFDGLfett-avanFdvlf--------ksseAPLLNHWAAWDVa-------------------- 263 Coccidioides im...
KDE09872     402 lktpnWeeVVEKCEELLWMATVLYA---SstrpgyACKP-KMDFFIMHGLTSVLFLPAILEVv-S---PHlrpY----IL 469
XP_011121851 302 ----eKaaLLTAFQKQVEASVMLFAtshK-------VADpQYDFFLAHAVTTAHALRIILPHvdT--------LqtwhLV 362
XP_054125050 265 ----dP---TTYFRESQKAAVALFTgakI------PAAGgKYNKSLLHPLLMSHAIHLILPHtpDkvhIS--------LV 323
XP_002487961 267 ----dL---TTHFRDSQKAIVSLFLgt--------sNSEnKYDKCLLYPLLMSHAIQVLFPHipGkvhIS--------LV 323
XP_002563152 262 ----nP---IEQFRESQELAAALLVg-tAp-----DDSPgHYDWFFALNLATSHAVRVVLPFipPqfqIS--------LL 320
XP_050468487 260 ---sdP---VKSFRESQELAVALLTatsSs-----DNRDaKYDFFFVHVLTTSHAVRVLLPLipAkfqIP--------LV 320
Q0CX98       262 ----nP---EEQFRETQEVAAALLTatrA-------EPAqKYDFFLVHVLTTSHAVRVLLPLipGrfqLS--------LI 319 Aspergillus ter...
XP_003015459 269 ----qDanLTEQLHAMQRLATTLMAtr---------hNGkQHDFFFDHLLTTTHALRVIIPLvpKkfhGP--------LL 327
XP_002843782 251 ----kEtgLTEQLRTIQRLAATLMAtr---------hAGkQHDFFFDHLLTTTHALRVIIPMmpTkfhES--------LL 309
XP_001248575 264 ----dA---TEQFEAIQRFATALLVn----------sGAkPHNFFFVHLLTTTHALRIIFPSipAqyhVN--------LL 318 Coccidioides im...
KDE09872     470 HTHFRMIVSYWISRGRPNLW------IKEtlmaaplypmppdasspstsavarylaslharkegelgpdgvpktpqvdan 543
XP_011121851 363 RAHMVLMSQVYLSQCKPTIKdw---fIEDyd------------------------------------------------- 390
XP_054125050 324 QQWWLTTLAIYVAQLRPEIGfd---vIAAhd------------------------------------------------- 351
XP_002487961 324 QQWWLTTLAIYVAQLRPDIDfd---lIEGyd------------------------------------------------- 351
XP_002563152 321 RQWWLICVGIYVAQLRPEIRid---qIRDyd------------------------------------------------- 348
XP_050468487 321 RQWWLMTLAVYIGQLRPEINlh---sVRKyd------------------------------------------------- 348
Q0CX98       320 RQWWLLTLAVYIAQLRPEVNvd---aVRDvq------------------------------------------------- 347 Aspergillus ter...
XP_003015459 328 RQWFLLAVAIYIAQLRPKIDak---dIECys------------------------------------------------- 355
XP_002843782 310 RQWFLLALTVYIAQLRPKIEin---dIGCyn------------------------------------------------- 337
XP_001248575 319 RQWWLLALGLYIAELRPQFNassinaIKDyd------------------------------------------------- 349 Coccidioides im...
KDE09872     544 grlrleeelaeatetpldllggGNPWSTVLAsa---vdHPDDHVAKVIRSL 591
XP_011121851 391 --------------------igNKDWEYIRKkalegeyKYDAHYVKILRSL 421
XP_054125050 352 --------------------tqGKNWGWIKQqalesqhATDAYFLQTLRVL 382
XP_002487961 352 --------------------meGKDWNWIRQqalkgphAMDAYFVSTLRVL 382
XP_002563152 349 --------------------lnGKDWEWVAEnavngefSSNVQFVRTTRAL 379
XP_050468487 349 --------------------teGKGWGYMKDkalhgehSTETHYIKALRVI 379
Q0CX98       348 --------------------lgGRDWEWTARkatkgeySTDAHYVKAIRAL 378 Aspergillus terreus NIH2624
XP_003015459 356 --------------------idGKDWAWVDKqaltqemAISPHYIKPLRTL 386
XP_002843782 338 --------------------reGKDWDWVDKqaltnemAVSPHYIKPLRTL 368
XP_001248575 350 --------------------leGRDWNWVSQhalhhkmSTSAHYIKPLRTM 380 Coccidioides immitis RS
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