4OI6


Conserved Protein Domain Family
SCO4226-like
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pfam14026: SCO4226-like (This model is not part of the current CDD release)
Nickel responsive protein SCO4226-like
This family of proteins is found in prokaryotes, including the nickel responsive protein SCO4226 from Streptomyces coelicolor. SCO4226 adopts a dimeric configuration able to bind four nickel ions, with each monomer showing a typical ferredoxin-like fold with five beta-strands packing against two alpha-helices. It seems to play a role in cellular nickel homeostasis, detoxification, and/or nickel utilization in specialised cytoplasmic compartment.
Links
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Statistics
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PSSM-Id: 521045
Aligned: 70 rows
Threshold Bit Score: 59.1478
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OI6_A             11 FXDVHRGXHGITSDQLHQAHQADLAVEKD-----ENVHFEQAWADPASgtIYCLSEGPSAEAVQRVHERAGHKADEIHE 84  Streptomyce...
jgi:B1NLA3E_20820  99 YLVEWNIPENITMEQYLARKNKNSVHYQEv----PEVAFSRTYVCEDMtkCLCFYDAPNVAAVKRAREAVQTPIDSITE 173
5_pfamImport        1 YLVEWDIPAEIDMETYLTRKKEKSPLYANi----PEVSFLRTYVREDTakCLCFYNAPDEDAVRRAREVVSTPVSRLHQ 75 
WP_013678257      100 YLVEWDFPDGLDMDTYLARKKAKAPLYANv----PEVSFLRTYVREDMtkCLCFYDADDEAGVVKAREVVDTPIDRLHQ 174 Pseudonocardia
WP_012851814      104 YLVEWDLPAELDMESYLARKKANAPKYAEv----PEVSFLRTYVREDMakCLCLYDAPDEEAVRRARKAVQAPVDRLHa 178 Thermomonos...
WP_012398392      102 YLVEWDIPAEITMEQYLTRKKANSPKYAEv----PEVSFLRTYVREDTakCLCFYNAPDEDAVARARAAVDTPFDRMfk 176 Kocuria
WP_015234719        4 FMADRNLPG-ITMDQLAGAQQAAIQKSQDsteqgRPVKYLRSMYVPGDdrCMCLFEAESPDDVRRVNDEAGIPYERVVE 81  Deinococcus...
WP_012176483        7 FMVVHNDPG-VTCEAVQANWRKLANH--------ESASWIRTYYNQAKglRYCVWMAQSEKELKKIFTEIGIGWESITP 76  Desulfosudi...
WP_004074226        7 YMMIHNSPE-VDWEVVKENWRKLAGV--------EAATWIKTYYNKDKgmRFCIWLAPTEEILKDIFTEIGISWESITL 76  Desulfobact...
WP_015903289        7 FMTVHKNPG-IDFKLVQSNWQKMANM--------DDATWVRTYFNKNQgiRYCIWLAHDKEALIKIFNGVNVNYESILQ 76  Desulforapu...
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