4RCL,5XFS,6VHR


Conserved Protein Domain Family
ESX-1_EspG
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pfam14011: ESX-1_EspG (This model is not part of the current CDD release)
EspG family
This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.
Links
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Statistics
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PSSM-Id: 521037
Aligned: 124 rows
Threshold Bit Score: 67.3196
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4RCL_A         14 QAWCLADVLGAGS-YPWVLAIT--PPYS-DHSQRSAFLAA-QSAELTRM-GVVnSAg-AVDPRVAQWITTVCRATQWLDL 86  Mycolicibacter...
O53943         16 GFWMLQALLDIRHvAP---ELRcrPYVS--TDSNDWLNEH-PGMAVMREqGIV-VNd-AVNEQVAARMKVLAAPDLEVVA 87  Mycobacterium ...
16_pfamImport   4 GLWVLQVLAGVEVvAP---ELGlrPVMPrVETPQLALAHP-VALELREH-GVI-DAagAVDRTVVEWLTVLARRDIALLL 77 
17_pfamImport   4 GLWVLQAVTGIETlCP---ELGlrPLLPrLDTADRAVQHP-IAEELTEI-GAL-DGqgEADPMIREWLTVIMRRDVALLL 77 
P9WJC9          8 GLWVLQAVTGVEQtCP---ELGlrPLLPrLDTAERALRHP-VAAELMAV-GAL-DQagNADPMVREWLTVLLRRDLGLLV 81  Mycobacterium ...
Q745F9          8 GLWVLQAVTGIEQtCP---ELGlrPLLPrLDTPERALRHP-AAAELVAA-GAL-DEagNVDPMIREWLTVLLRRDLGLLV 81  Mycobacterium ...
WP_013125019   19 ELSLLMRLADVTElAPIVLAVH--PNVY-RPDDQSAVDLA-VLPGLIAA-GLV-DAdgAIDPEVARWLRALQAPAAEIAL 92  Tsukamurella p...
WP_025347928   19 AALLLQHLTGIDSy-PSVLALL--PNVF-RIDDRDRVRAV-VTEQLAEA-GAV-VDg-RVHPVIEQWLHCLYRPDVELAA 90  Nocardia nova
WP_013138286   15 TLEYVRKLAKTESv-PTVLACY--QGFYvDVEQRRKEWDL-MNAELNEK-GIL-RGe-AVHPELQAWLEALDHPDRELSG 87  Segniliparus r...
5XFS_C         24 GFWMLQALLDIRH-VAPELRCR--P-YV-STDSNDWLNEHpGMAVMREQ-GIV-VNd-AVNEQVAARMKVLAAPDLEVVA 95  Mycobacterium ...

4RCL_A         87 RFVS----------G--------------------PGdLL----------RG-MVARRSEETvVALRNAQLVTFTAM--- 122 Mycolicibacter...
O53943         88 LLSRgkllygviddE--------------------NQ-PPgsrdipdnefRV-VLARRGQHWvSAVRVGNDITVDDV--- 142 Mycobacterium ...
16_pfamImport  78 RVQDprr-----------------------------------------veAQaVLARFAQWWvVAERCGDGVRIGGA--- 113
17_pfamImport  78 QLNF----------------------------------PGrpygdpqhmtRV-SINRFASWWvVLERHDQEIRLYPA--- 119
P9WJC9         82 TIGVpgg----------------------------------------eptRA-AICRFATWWvVLERHGNLVRLYPA--- 117 Mycobacterium ...
Q745F9         82 MIAVpgr----------------------------------------epsRA-SICRFATWWvVLERHDQLVRLYPA--- 117 Mycobacterium ...
WP_013125019   93 RVFDgds-----------------------------------------alRG-AIVRHDDLVvVVFRHDDLLTLQGY--- 127 Tsukamurella p...
WP_025347928   91 RIVS-----------------------------------TgldgapkgmlRL-SLVRSGERHvLAVRSDDHVVIQSV--- 131 Nocardia nova
WP_013138286   88 RVKRges-----------------------------------------mlRM-ALVRRGDVHaLAIRYGDEVVIQNF--- 122 Segniliparus r...
5XFS_C         96 LLSR----------GkllygviddenqppgsrdipDN-EF----------RV-VLARRGQHWvSAVRVGNDITVDDVtvs 153 Mycobacterium ...

4RCL_A        123 DIghqHA-------LVPVLTAGLSG---RKPARFDDFALPAAAGARADEqiRn---------gAP-----LAEVLEF--L 176 Mycolicibacter...
O53943        143 TVs--DSa-----sIAALVMDGLEsihhADPAAINAVNVPMEEMLEATKswqe------sgfnVF-----SGGDLRR--M 202 Mycobacterium ...
16_pfamImport 114 GTs--VSegeagavLQAQIERLCGV---VPPVQFRPVDVETTALLAAA----------------G-----SPESVQNylT 167
17_pfamImport 120 GTa--TDqaaaadlVVGQIERLCGV---TEAAPLRPVTLDTKELLEQV----------------R-----DRDGLRNylA 173
P9WJC9        118 GTa--SDeagagelVVGQVERLCGV---AEAAPLRPVTVDADELLHAV----------------R-----DAGTLRSylL 171 Mycobacterium ...
Q745F9        118 GTa--SSeaaaseiVVGQIERLCGV---AEAAPLRPITLDTEQLLASV----------------H-----DTASLRAflL 171 Mycobacterium ...
WP_013125019  128 RTd--GEdfd--stVVDPVWRVLGS---CDPADFDSLTLGAAELREIVS--MynpastdprgeRE-----FRGRLRE--H 191 Tsukamurella p...
WP_025347928  132 FDs--GRrl---dtLAAVLAAALGP---AEALRFEPFAAWSEEFDEMSG--Ep----------dE-----RRRALVE--F 184 Nocardia nova
WP_013138286  123 EYd--AQkss--gqLARAALVVLGE---GVIPDFNRVSAPTQSIVDAMP--Rnvd-------ldA-----VYTSLLR--V 179 Segniliparus r...
5XFS_C        154 DS---AS-------IAALVMDGLESihhADPAAINAVNVPMEEMLEATK--Sw---------qESgfnvfSGGDLRR--M 210 Mycobacterium ...

4RCL_A        177 GV--PPSARPLVESVFDGRRTYVE--IVAGeHRD-GHRVTTe---vGVSIIDTPHGR--I--LVHPTKaFDGEWISTFTP 244 Mycolicibacter...
O53943        203 GI--SAATVAALGQALSDPAAEVAvyARQYrDDAkG-PSAS-----VLSLKDGSGGRiaL--YQQARTaGSGEAWLAICP 272 Mycobacterium ...
16_pfamImport 168 SQpfSAEQLQILLAATDPTRSTQTsiAALQaGVEtGRPTRThihpgAVSIIDIPAGR--V--VVEHSVsAGRQQ-MLVVP 242
17_pfamImport 174 AQrlDIDQQQTLLMASDPEVSGQAniVALQpGAGpDELARMaigdtSVLISDTPAGR-----VCVENIdNGGRRYQIVSP 248
P9WJC9        172 SQrlDVDQLQMVTMAADPTRSAHAtlVALQaGVGpEKSARIlvgdsTVAIVDTAAGR-----ICVESVtSGQRRYQVLSP 246 Mycobacterium ...
Q745F9        172 EQrlDADQLQTVLTAADSARSAHAniVALQaGVGpDELARVavgdsSVSIVDTPGGR-----VCIESVvSGQRRYQILSP 246 Mycobacterium ...
WP_013125019  192 DL--PPHTVDVLVDAARYSGRRAE--VVYHrVDLnGVRTQAq---wALGVMDTDQGR--V--LSTTTRgRGGDNDVILSP 260 Tsukamurella p...
WP_025347928  185 GA--QPRTAGMLSRVLDEVVRRAE--IVMIeHRD-GATNQPe---aCVNVLDTTSGR--I--IVTPSMaLDGGIRATCAP 252 Nocardia nova
WP_013138286  180 GA--SQKDAKVLATIMATVEVQSE--FVVYeRGD-GPRARGk---gAVSVFDSPKGR--F--VSSPSVaSDGEIWSTMTP 247 Segniliparus r...
5XFS_C        211 GI--SAATVAALGQALSDPAAEVAv-YARQyRDDa--KGPSa---sVLSLKDGSGGR--IalYQQARTaGSGEAWLAICP 280 Mycobacterium ...

4RCL_A        245 GSADAIAMAVE 255 Mycolicibacterium smegmatis MC2 155
O53943        273 ATPQLVQVGVK 283 Mycobacterium tuberculosis H37Rv
16_pfamImport 243 GTASNIAAAVN 253
17_pfamImport 249 GSRADVANAI- 258
P9WJC9        247 GSRSDIGGAVQ 257 Mycobacterium tuberculosis H37Rv
Q745F9        247 GSRSDIGGAVQ 257 Mycobacterium avium subsp. paratuberculosis
WP_013125019  261 GTRRRFAEGLN 271 Tsukamurella paurometabola
WP_025347928  253 GDDTALRAGVA 263 Nocardia nova
WP_013138286  248 GTDHRISQAfn 258 Segniliparus rotundus
5XFS_C        281 ATPQLVQVGVk 291 Mycobacterium tuberculosis H37Rv
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