8J6O,8XBS


Conserved Protein Domain Family
SID-1_RNA_chan

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pfam13965: SID-1_RNA_chan (This model is not part of the current CDD release)
dsRNA-gated channel SID-1
This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.
Statistics
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PSSM-Id: 521015
Aligned: 30 rows
Threshold Bit Score: 569.209
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8J6O_A        442 QPQYFKYEF-PEGVDSVIVKVTSNKAFpCSVISIQDVLCPVYD--LDNNVAFIGMYQTMTKKAAITVQRKDFPsNSFYVV 518  synthetic con...
3_pfamImport    2 KPLGYFLDAkEQNVNAFHITVTSDDDI-CANLITVPADEPLYDrrVDLDKVDNRRILSFTRRADVLFPNSEIAnFEKFRI 80  
EGT42616      205 KPIGFFLDAiEQNVKSFHITLLSDDDF-CASLITVPANESIYDrpVDADKADNNRVITFTKRADIFFSQTEIEtFKSFRI 283 
XP_053581493  200 KPMGFFLDAkEQDVKSFHITVTSEDDI-CANVITVPANESIYDrpVDSDKADNQRVITFNRRADIFFSEKEIElFTSFRI 278 
XP_045093785  193 KPIGFFLDTeEQIVKSFHITLTSADDI-CANVITAPANESIYErpVDSDRADNRRVLTFTRRADIFFSETEIQlFKTFRI 271 
Q9GYF0        152 EPVYLRYDI-PGDVDSVAVHLDSNSTI-CMTVSVQKIGCPVFD--LPDNVNSMGLHQTMTTSATIPVEKSRMS--SFYVV 225  Caenorhabditi...
EFO97233      111 ENFHIGYTF-PDYVEKVNVRITSDSDV-CAKIYARKANCPAFDasGLVELSDSSYYQSFTTFGGFSLRKSDIG-PKFHLA 187 
EFA10693      176 ESKYYYYKFhDKKNTSAMIEINSDDDV-CLTVSIQDSFCPVLD--LDKDITYEGKYQTINRKGGMTIRQREFP-DGFFLV 251 
Q9GZC8        198 KPIGFFLNCsEQNISQFHVTLYSEDDI-CANLITVPANESIYDrsVISDKTHNRRVLSFTKRADIFFTETEISmFKSFRI 276  Caenorhabditi...
8XBS_A        214 KPIGFFLNCsEQNISQFHVTLYSEDDI-CANLITVPANESIYDrsVISDKTHNRRVLSFTKRADIFFTETEISmFKSFRI 292  Caenorhabditi...
8J6O_A        519 VV-VKTEDQACGGSLPFYPFaedep-vdqghRQKTLSVLVSQaVTSEAYVSGMLFCLGIFLSFYLLTvllacwenwrqkk 596  synthetic con...
3_pfamImport   81 FVlISPDDSLCGASSRKTAL-----------QNKKLSLEFVK-LNDASYSVPLIAMFTFLAIPALIF------------- 135 
EGT42616      284 FVfISPVDSPCSTNSSRKTFn----------ENKKVTFEFAK-LEPSSYFFPTALMMAFLATPVLLF------------- 339 
XP_053581493  279 FVfVSPVDSPCSLKTSRKTFn----------EQKKMTFEFKK-LEPDSYFMPTLAMIAFFISPCLIV------------- 334 
XP_045093785  272 FVfISPVNAPCSGNTSRKNYn----------EIKKITFDFTR-LEPNSYFVPTLAMLVFFASPCLIF------------- 327 
Q9GYF0        226 FV-VNTNDDLCSEILSIKPNkptk----fplRMKSFNVTIESsMKIFDYTIPIVFWACILLLVTIVV------------- 287  Caenorhabditi...
EFO97233      188 FT-VEPDDVVCETYTNLTENp---------yRVKNVNISVIPiFDE---TVQPIVPVVLYISVSFAV------------- 241 
EFA10693      252 FV-AKADNYQCSQKHSVLLVehrkqhlilanRTSTITFTINKgINGKEYEIASLATLGALLSFCIVS------------- 317 
Q9GZC8        277 FVfIAPDDSGCSTNTSRKSFn----------EKKKISFEFKK-LENQSYAVPTALMMIFLTTPCLLF------------- 332  Caenorhabditi...
8XBS_A        293 FVfIAPDDSGCSTNTSRKSFn----------EKKKISFEFKK-LENQSYAVPTALMMIFLTTPCLLFl------------ 349  Caenorhabditi...
8J6O_A        597 ktL--LVAIdracpesghprvladsfpgsspyegynygsFENVSgst---------dgLVDSAgtgdlsygyqgrSFEPV 665  synthetic con...
3_pfamImport  136 --L--PFVT------------------------------LTRFR--------------SMPIA------------TDHLL 155 
EGT42616      340 --V--PALI------------------------------LNRIRnts---------tsQSTLI------------SFAPD 364 
XP_053581493  335 --A--SILA------------------------------VNVWR-------------------------------NRDPS 349 
XP_045093785  328 --I--ASLT------------------------------VNVIRnrs---------dlVADLI------------SFSSD 352 
Q9GYF0        288 --F--VYHY------------------------------FDGIWerrfvsraythledNAQEQ------------RIRDF 321  Caenorhabditi...
EFO97233      242 --I--VMTY------------------------------FQCKW------------------------------------ 251 
EFA10693      318 --T--IMIF------------------------------AFTRW---------------GTIS------------KFRP- 335 
Q9GZC8        333 --LpiVINI------------------------------IKNSRkla---------psQSNLI------------SFSPV 359  Caenorhabditi...
8XBS_A        350 -pI--VINI------------------------------IKNSRkla---------psQSNLI------------SFSPV 375  Caenorhabditi...
8J6O_A        666 gt---rPRVDSMSSVEED-DYDTLTDIDSD-----KN-----VIRTKQYLYVAd-lARKDK--RVl----rKKYQIYFWN 724  synthetic con...
3_pfamImport  156 ------DLSTDLSSSSQPsPLIVLDESATD-----NS-----LGIAEVNADIT---VLEDV--KL------TDSLSLHGE 208 
EGT42616      365 t---------------pDqSYQVEEGPSTD-----ND-----IVVPEEEn-----lQNQEG--NIip--lpEDSLSLHGQ 410 
XP_053581493  350 ------NTSADLVSFESDePNHPNPNTSDE-----QL-----VVMEEEEVNLQn-hENLQN--HVeavsvkQDSLSLHGQ 410 
XP_045093785  353 ------QSANTSAIAENNmAHNEIAVIPEE-----EN-----Lq-----------vQEIEP--IPi----kQDSLSLHGQ 399 
Q9GYF0        322 ------YDFQRMSEDDDLkDYDLLTDCQD------MM-----VVRAKASLTVAd-lSMTPY--EEr----eLKYDVYKIA 377  Caenorhabditi...
EFO97233      252 ------LNRNENNEPNSQqEIDSENSLVVD-----KI-----ILFDKPANIVSynkYHKNK--LIn----eSKYFNFLLF 309 
EFA10693      336 ------SGDELDADWKEPpEPPITRELKHE-------------LLSRQALTVNl-lARAPE--Kd-----kRRSYNYLWH 388 
Q9GZC8        360 pseqrdMDLSHDEQQNTSsELENNGEIPAAenqivEE-----ITAENQETSVEe-gNREIQ--VKip--lkQDSLSLHGQ 429  Caenorhabditi...
8XBS_A        376 pseqrdMDLSHDEQQNTSsELENNGEIPAA-----ENqiveeITAENQETSVEe-gNREIQvkIPl----kQDSLSLHGQ 445  Caenorhabditi...
8J6O_A        725 IATIAVFYALPVV-QLVITYQTVVNVT--GNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNr 801  synthetic con...
3_pfamImport  209 MLRYPVAIILPVLmHTAVEYHNWSKSSmaNRDEMCFYNHACANPYGEFRAWNNIISNIGYAIYGLAFVAITVGRRRRSR- 287 
EGT42616      411 MLKYPLAIILPVFmHTAVEYHEWTTSTmaNRDEMCFHNNACARPYGELRAWNNIISNIGYAIYGLVFIAITMCRRWRH-- 488 
XP_053581493  411 VLRYPIAIILPVLmHTAVQFHNFTFSTmaNRDEMCFHNSACSKPLGELRAWNNMISNIGYAIYGFVFILITMFRRWRH-- 488 
XP_045093785  400 MFKYPVALILPVLmHTGVEFHNFTTSTmaNRDEMCFHNNACAKPLGELRSWNNMISNIGYAIYGLVFIMVTMCRRWRH-- 477 
Q9GYF0        378 LAIIGIFYNITVL-QLIISKAGSLRQS--GDLDECTFNFQCARPLWYFVAFNNVVSNGGYVYFGTLIIVMNYCRERSFRr 454  Caenorhabditi...
EFO97233      310 QFITTIILSVPVLqQLKSIFPNENTLTknVNLDNCYLNYLCSSSVFGFNCFNGMISSNSMVVVGVVNLFIVFRKKIFGYk 389 
EFA10693      389 ILSIAIFYSIPVV-QLVITYQRVVNRT--GDQDMCYYNFLCANPAFGLSDFNHIFSNVGYIIVGILFLGVVLHRQtk--- 462 
Q9GZC8        430 MLQYPVAIILPVLmHTAIEFHKWTTSTmaNRDEMCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGRHE- 508  Caenorhabditi...
8XBS_A        446 MLQYPVAIILPVLmHTAIEFHKWTTSTmaNRDEMCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGRHe- 524  Caenorhabditi...
8J6O_A        802 allrndlCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHpDINASAYSA 881  synthetic con...
3_pfamImport  288 -------QLVGYGVHESTLIDVTIGVFMVLQAIASATYHICPSNVSFQFDTPCIQMICCLLIIRQWLVRL-ESPSAAYSN 359 
EGT42616      489 -------GSPVVGIYECTLLDVTIGVFMILQAIASATYHICPSDVAFQFDTPCIQVICGLLIIRQWRVRQ-ESPSASYTN 560 
XP_053581493  489 -------HSALVGTYECTLLDITIGVFMILQAIASATYHICPSDIAFQFDTPCIQVICGLLIIRQWLVRK-ESPSPAYTN 560 
XP_045093785  478 -------HSPLVGTYECTLLDITIGLFMILQAIASATYHICPSDIAFQFDTPCIQVICGLLIIRQWLVRQ-ESPSPAYTN 549 
Q9GYF0        455 lfavqptLAERYGLPQHSGLMTAIGLAVIMEGISSATYHVCPNNINYQFDTALMYVIGMLGKLKIWSLRHpDMVVSAYHA 534  Caenorhabditi...
EFO97233      390 s----pkPPTAHGVQKQDAAKVVTLLGMFAMGLFWTLISNCPHKSSLHFYTYTHSWTFISAFMWLHAKRHgTHVWQHFFI 465 
EFA10693      463 ------iPNSSTGIPVHYGVYYAMGIALIIEGILSACYHICPSQSNYQFDTSFMYVMAVLCMIKLYQNRHpDVNATAYAT 536 
Q9GZC8        509 -------YSHVFGTYECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRH-ESPSPAYTN 580  Caenorhabditi...
8XBS_A        525 -------YSHVFGTYECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRH-ESPSPAYTN 596  Caenorhabditi...
8J6O_A        882 YACLAIVIFFSVLGVVFGKGNTA--FWIVFSIIHIIATLLLStqlyymgrwkldsgiFRRILHVLYTdcirqcsgpl--- 956  synthetic con...
3_pfamImport  360 LLLVVVVSVNFLVSALSKTWYIR--YLIAGIHMFIISSICLA---------------KKRMLGINESafrkqisl----- 417 
EGT42616      561 LLLFGVVSLNFLISAFSKAKYVR--YLIAMIHISAIASMCLAkrr----------tlETKKTFQVFTacf---------- 618 
XP_053581493  561 MLLLAVVSLNFLISTLSKSSRVR--YVIATIHFIAVATICLKkqkkmgsrkd---------------------------- 610 
XP_045093785  550 ILLFCVVSLNFLISACSKASGIR--YLIAIIHFGVVATVCLA---------------KRKTLRSKqvykvf--------- 603 
Q9GYF0        535 FGFLGVFLMAAIAGVYVH--NMI--FWALFSIIYIASMLLVSlefyfkgiwtlnlreLRNSIRLSWVssrhlscvvp--- 607  Caenorhabditi...
EFO97233      466 IALFSVYGCLSFLEYAYEMTSNYvaF-LFKNILFVFVCVSSTvfiafny-vyerpsgLQKHQWISSPlrkkeiiqcdene 543 
EFA10693      537 FTVLGMAIFLAMIGILNG--SLT--VWIVFVVIYSLLCAYISfkiyfi---sfvfdgFKQLKQSLKSsnkveaiapi--- 606 
Q9GZC8        581 ILLVGVVSLNFLISAFSKTSYVR--FIIAVIHVIVVGSICLAkersl-----gseklKTRFFIMAFS------------- 640  Caenorhabditi...
8XBS_A        597 ILLVGVVSLNFLISAFSKTSYVR--FIIAVIHVIVVGSICLAkersl-----gseklKTRFFIMAFS------------- 656  Caenorhabditi...
8J6O_A        957 ---yvdrmvllvMGNV---INWSLAAYGL-IMRPN--DFASYllaIGICNLLLYFAFYIIMKLR----SGERIKLIPLLC 1023 synthetic con...
3_pfamImport  418 -----tfiiyysICNI---TMLLVYLVSA-KIHLN--QIVTY---CCIFNCIMYLIYYALIKYM----CHERISHLAKLY 479 
EGT42616      619 ----------aaINFL---IMLTYLAPSI--LHLN--QIVTY---CFISNCIMYLVYYAVMKLV----SRERIGLKGKVC 674 
XP_053581493  611 ---aakfmiffaVANF---ILMTMYLTSS-KIHLN--QITTY---CFILNCIVYLTYYAIMKAV----SRESIGLKAKIC 674 
XP_045093785  604 -------vgtfaIFNF---FAITIYVTSS-YIHLN--QISTY---CFILNCILYLTYYALMKFA----SRESIELKAKVC 663 
Q9GYF0        608 --aykarffvilLLNI---ANTAVVVYGL-EAHPK--DFLSFlliPFIGNLFIYIIYYILMKMI----YREKIPKRAIAL 675  Caenorhabditi...
EFO97233      544 iyrplpskkvfaVGLIllsVGWSVFS-----FYPDdiSVTKCifcLEQCQVGFYLVYYVVQKIRfersTFNRKFVLTLVL 618 
EFA10693      607 ---rksrfallvIANI---INYAMLITGLcLYNTGvtDFGTFllgLLMGNSVLYAVFYTGMKLV----NGERICFEAIIY 676 
Q9GZC8        641 ------------MGNF---AAIVMYLTLS-AFHLN--QIATY---CFIINCIMYLMYYGCMKVL----HSERITSKAKLC 695  Caenorhabditi...
8XBS_A        657 ------------MGNF---AAIVMYLTLS-AFHLN--QIATY---CFIINCIMYLMYYGCMKVL----HSERITSKAKLC 711  Caenorhabditi...
8J6O_A       1024 IVCTSVVWGFALFFFFQGLSTWQK--TPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKI 1101 synthetic con...
3_pfamImport  480 GSLALVGWFVSAWFFFQDDMDWTQ--SAAVSRSLNKPCVLLQFFGSHDLWHIFGAMAGLFTFLFVSYVDDDLLNIPKCSV 557 
EGT42616      675 GGLAVIGWIVAAVFFFQDDTDWTR--SSAASRALNKPCLLLNFFGSHDLWHIFGALAGLFTFLFVSFVDDDLVNTPKSAI 752 
XP_053581493  675 GTLAIVGWITAGYFFFQDDTDWTR--TAAASRALNKPCLLLDFFGSHDLWHIFGALAALFTFFSVSFVDDDLVNTPKSSI 752 
XP_045093785  664 GVSAIFGWLIAGFFFFQDDTDWTR--TAAMSRALNTPCLLLDFFGSHDLWHMFGAIAGLFTFLFVSFVDDDLINTPKSSI 741 
Q9GYF0        676 LFAAVISWTCAGILFNQRVSDWSK--MPAISRELNKPCIFLNFYDNHDLWHLSSAFAIFFSFTAINVIDDDLMFVMRNTI 753  Caenorhabditi...
EFO97233      619 IILTSIPVIIFYLIIINYESPWYLlwTPAKSRTLNRECITPGI-DWADMDYYMTSAIFILFIIFMDFIDSNVKHIPKKHI 697 
EFA10693      677 GLLAIAAWATATVYFLDNATLWTV--TPAESRQWNQECIVMSFYDKHDVWHLLSAPALYLTFMFLLSLDDDLVDTKREEI 754 
Q9GZC8        696 GALSLLAWAVAGFFFFQDDTDWTR--SAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSI 773  Caenorhabditi...
8XBS_A        712 GALSLLAWAVAGFFFFQDDTDWTR--SAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSI 789  Caenorhabditi...
8J6O_A       1102 YVF 1104 synthetic construct
3_pfamImport  558 TVF 560 
EGT42616      753 NVY 755 
XP_053581493  753 NIF 755 
XP_045093785  742 NMY 744 
Q9GYF0        754 RVF 756  Caenorhabditis elegans
EFO97233      698 FVF 700 
EFA10693      755 TVF 757 
Q9GZC8        774 NIF 776  Caenorhabditis elegans
8XBS_A        790 NIF 792  Caenorhabditis elegans
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