8I9Z,8I9W


Conserved Protein Domain Family
CTE_SPB4

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pfam13959: CTE_SPB4 (This model is not part of the current CDD release)
ATP-dependent rRNA helicase SPB4-like, C-terminal extension
This short domain is found at the C-terminus of many helicase proteins, including ATP-dependent rRNA helicase SPB4 from Saccharomyces cerevisiae, which is involved in the biogenesis of 60S ribosomal subunits. SPB4 is organised into four domains: dual RecA domains (pfam00270 and pfam00271), a C-terminal extension (CTE, represented by this entry) and a C-terminal tail (pfam23681). This domain packs closely onto the catalytic core and engages the four nucleotides immediately 5' to those within the RNA binding pocket. It shows a mainly alpha- helical structure.
Statistics
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PSSM-Id: 521012
Aligned: 347 rows
Threshold Bit Score: 34.3004
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8I9Z_CW       452 DREVFQLAQRAFVSWARsyMEHQATS--IFRVADLDWFDLAKGYGLLELP 499 Thermochaetoides thermophila DSM 1495
Q9UTP9        431 DNDIKYIGQKAFISYLR--SIYLQKDkdVFQLDKLPVEAFADSLGLPGTP 478 Schizosaccharomyces pombe 972h-
Q6CRF4        438 DPELKYLGQKAFISYVR--SIYIQKDkeVFHFDKIPLEQFANSLGLPGAP 485 Kluyveromyces lactis NRRL Y-1140
Q6CGD1        432 SPEIKYLGQKAFISYYK--SIFIQKDkeIFQFEKIPSEAFAESLGLPGAP 479 Yarrowia lipolytica CLIB122
XP_007874191  430 DPEIKYLGQRALISYLK--SIYLQKDkeVFKFEDLSIEEFSSKMGLLGVP 477
16_pfamImport   1 SPEIKYLGQRAFISYVR--SIHLQKDksIFKIEELPVDRFAESLGLPGAP 48 
XP_006677211  455 SPDIKYLGQKAFICYLR--SIYLQANksIFNVEQMPVDLFAESLGLPGAP 502
ESK87527      447 DPEIKYLGQRAFVSYLR--SIHLHKDksIFKLTEYPINAFAESLGLPGTP 494
XP_050199608  448 EPEIKYLGQRAFVSYLR--SVYLHKDksIFKVDQLPVDRYAESLGLPGTP 495
CCA72645      444 DPDIKYLGQRAFISYLR--SIYLQKDkaTFKLEGLPLEEFAEALGLPGAP 491
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